Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This study tests a combination of two drugs, becotatug vedotin and zimberelimab, in 30 people with recurrent or metastatic cervical, vulvar, or vaginal cancer. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have already tried at l…

This early study is testing an injection called IASO208 in 12 adults with certain types of blood cancer that have returned or not improved with standard treatments. The main goal is to see if the treatment is safe and to find the right dose. Researchers will also look at how well…

This Phase 3 trial tests whether adding the immunotherapy drug cadonilimab to standard chemotherapy and radiation can improve outcomes for people with locally advanced cervical cancer. About 378 participants will be randomly assigned to receive either the new combination or stand…

This early-stage study tests a new drug called YKST02 in 12 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The main goal is to see if the drug is safe and tolerable, and to check if it reduces protein in the urine, a sign of kidney damage. Particip…

This study tests whether moxibustion, a traditional Chinese medicine technique that involves burning dried mugwort near the skin, can help people with a severe complication of stem cell transplants called graft-versus-host disease (GVHD) that does not respond to steroids. The tri…

This early-phase study tests a new treatment called CT1182 for people with B-cell non-Hodgkin lymphoma that has come back or not responded to standard therapy. About 24 participants will receive the treatment to see if it is safe and how well it works. The goal is to find the bes…

This Phase 2 trial tests whether a single injection of stem cells from umbilical cords can help people with knee osteoarthritis. 100 adults aged 40-70 will receive either a low or high dose of stem cells or a placebo. The study measures changes in pain, stiffness, and function ov…

This study tests whether fecal microbiota transplantation (FMT) can help treat delirium in intensive care unit (ICU) patients. Delirium is a sudden confusion that affects up to 80% of ICU patients and has no proven drug treatment. The trial will give 60 patients either standard c…

This study tests a new treatment plan for people with high-risk rectal cancer that hasn't spread. Patients get a short course of radiation, then a mix of chemotherapy and immunotherapy before considering surgery. If the cancer disappears completely, patients may choose a 'watch a…

This early study is testing an experimental therapy called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The main goal is to see if it is safe and to find the right dose. Researchers will also look at how the body processes the therapy…

This early-phase study tests a new "universal" CAR-T cell therapy (CT1190B) for people aged 12-75 with B-cell acute lymphoblastic leukemia that has come back or not responded to standard treatment. The therapy is made from donor cells, so it can be given without needing the patie…

This early-stage study tests a new treatment called RD06-05, a type of CAR-T cell therapy, in 27 adults with autoimmune blood diseases like immune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), or Evans syndrome. The therapy aims to control the disease by targeting a…

This early-phase study tests a new treatment called CT1195E CAR-T cells for people with severe systemic sclerosis (scleroderma) that hasn't responded to other therapies. The treatment uses a patient's own immune cells, modified in a lab to target and attack the disease. The main …

This early-stage study tests a new drug called A-319 in 12 people with active rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and wh…

This early-phase study is testing a new type of immunotherapy called universal CAR-T cells in 12 people with moderate to severe lupus that hasn't responded to standard treatments. The cells are designed to target and destroy faulty immune cells driving the disease. The main goals…

This early-stage trial is testing a new drug called cizutamig in 28 people with severe rheumatoid arthritis that hasn't responded to other treatments. The drug works by directing the immune system to attack certain cells involved in the disease. The main goal is to check safety, …

This study tests a combination of three drugs (IN10018, nab-paclitaxel, and cadonilimab) in 25 women with a rare, aggressive cervical cancer that has spread or returned. The goal is to see if this treatment can shrink tumors or slow the disease. Participants must have already tri…

This study looks at whether adding branched-chain amino acid (BCAA) supplements to a standard liver procedure (TIPS) can help reverse muscle loss (sarcopenia) in people with cirrhosis and high blood pressure in the liver. About 164 patients will be randomly assigned to receive ei…

This study looks at whether a procedure called TIPS, which creates a bypass in the liver, can help people with advanced cirrhosis achieve 'recompensation' — meaning the liver partially recovers and complications ease. Researchers will follow 250 patients for one year after TIPS t…

This early-stage study tests a new drug called PRG-1801 in 6 adults with immune thrombocytopenia (ITP) that hasn't improved with standard treatments. The goal is to see if it is safe and can raise platelet counts to reduce bleeding risk. Participants receive a single infusion and…

This study tests whether a phosphate supplement in granule form can safely raise low blood phosphate levels in 60 ICU patients. Participants take the granules daily for up to 14 days, with doses adjusted based on how low their phosphate is. Researchers will check blood levels dai…

This early-stage study tests a new treatment called universal CD19/20 CAR-T cells for people with moderate to severe lupus that hasn't improved with standard therapies. The treatment uses specially engineered immune cells to target and potentially reset the faulty immune response…

This early-phase trial tests a new drug called ZZSW-01 in 6 people with B-cell blood cancers that have come back or not responded to other treatments. The drug is a special particle that carries instructions for the body to make its own cancer-fighting cells. The main goal is to …

This early-stage trial is testing a new drug called A-319 in 25 people with active or treatment-resistant systemic lupus erythematosus (SLE). A-319 is a type of antibody designed to target and help control the immune system cells that drive lupus. The main goal is to see if the d…

This study tests whether taking oral sorbitol, a common sugar alcohol, can enhance the effects of standard chemotherapy and an immunotherapy drug (tirellizumab) in people with locally advanced stomach cancer. Eighty participants will receive either sorbitol or a placebo alongside…

This early-phase trial is testing a new treatment called OriV508 for people with multiple myeloma or non-Hodgkin lymphoma that has come back or stopped responding to other treatments. OriV508 is a type of immunotherapy that uses a virus to deliver instructions to the body to make…

This study tests a new radioactive imaging agent that targets a protein called MSLN, found on some cancer cells. Researchers will use PET scans to see if this agent can better detect and stage ovarian cancer, lung adenocarcinoma, and pancreatic cancer in 100 patients and healthy …

This study is testing a new radioactive imaging agent that targets a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this agent can better detect and stage cancers like pancreatic, breast, lung, and others. The trial includes 26 healthy…

This early study is testing a new imaging agent called FL-261 in 12 people with advanced cancers like lung, colorectal, or head & neck cancer. The agent targets a protein called c-MET that is often found on cancer cells. Researchers want to see if FL-261 scans can safely and accu…

This study tests a new imaging agent called FL-091, which targets a protein (NTSR1) found on some cancer cells. Researchers will use it with PET or SPECT scans to see if it can better detect and stage cancers like head and neck, colorectal, and pancreatic cancer. About 100 adults…

This study tests a new PET imaging probe that targets a protein called CLDN18.2, found in some stomach, pancreatic, bile duct, and esophageal cancers. Researchers will scan 56 people (patients and healthy volunteers) to see if the scan can accurately detect tumors and guide treat…

This early-stage study is testing a new imaging agent called 68Ga-FL-031 to see if it can better detect and stage certain cancers, including small cell lung, breast, and nasopharyngeal tumors. Ten adults with suspected or confirmed cancer will receive both the new PET scan and a …

This study aims to see if new PET imaging agents can better detect and stage kidney cancer (renal cell carcinoma). Researchers will use special tracers that target proteins on cancer cells, such as PSMA, CAIX, and CD70, in 66 adults with suspected or confirmed kidney cancer and h…

This study tests an investigational drug called ALT001 for people with knee osteoarthritis. The goal is to see if it can reduce pain, improve movement, and boost quality of life. About 30 adults aged 50 to 75 will receive injections into the knee every two weeks for 12 weeks. The…

This study compares AI-assisted versus surgeon-planned screw placement in hip fracture surgery. About 334 adults with femoral neck fractures will be randomly assigned to one of two groups. The goal is to see if AI guidance leads to more accurate screw placement, shorter surgery t…

This study looks at why a procedure called TIPS (which helps blood flow in the liver) might also improve muscle loss (sarcopenia) in people with advanced liver disease. Researchers will measure a protein called FGF21 in the blood and track changes in muscle mass and strength over…

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stoo…

This study is looking at whether certain antibodies in the blood can help predict which patients with acute viral myocarditis (heart inflammation caused by a virus) will go on to develop dilated cardiomyopathy (a weakened, enlarged heart). Researchers will measure two specific an…

This study looks at 300 liver cancer patients who cannot have surgery and instead receive a treatment called TACE. Researchers will use artificial intelligence to analyze routine CT scans taken before treatment, measuring body composition like muscle and fat. The goal is to creat…

This study looks at how nutrition impacts the progression of bronchiectasis, a chronic lung disease. Researchers will measure things like arm circumference, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung …