Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This early-phase study tests a new drug called A-319 in 12 adults with active rheumatoid arthritis who haven't responded well to standard treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and…

This early-stage study is testing a new drug called A-319 for people with active or hard-to-treat systemic lupus erythematosus (SLE). The drug is a special antibody designed to target and help control the overactive immune cells causing the disease. The main goal is to see if it …

This study tests whether fecal microbiota transplantation (FMT) can help treat delirium in intensive care unit (ICU) patients. Delirium is a common and serious confusion that affects up to 80% of ICU patients and can lead to long-term brain problems. The researchers will give FMT…

This early-phase study is testing a new treatment called universal CD19/20 CAR-T cells for people with moderate to severe lupus that hasn't improved with standard therapies. The treatment uses specially engineered immune cells to target and calm the overactive immune system. The …

This study is testing whether a phosphate supplement given as granules (by mouth or feeding tube) can safely raise low blood phosphate levels in 60 ICU patients. Participants will take the supplement daily for up to 14 days, with doses based on how low their phosphate is. The stu…

This early-phase study tests a new "universal" CAR-T cell therapy (CT1190B) for people aged 12 to 75 with B-cell acute lymphoblastic leukemia that has come back or not responded to standard treatment. The therapy is designed to target two markers on cancer cells (CD19 and CD20) a…

This study tests whether injecting stem cells from umbilical cord tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 100 adults aged 40-70 will receive either the stem cells or a placebo. The goal is to see if this treatment can control the…

This early-phase study tests a new drug called YKST02 in 12 adults with IgA nephropathy, a kidney disease. The main goal is to see if the drug is safe and if it can reduce protein in the urine, a sign of kidney damage. Participants receive the drug by IV and are closely monitored…

This early study tests an experimental treatment called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The treatment uses a type of cell therapy (CAR-T) to target and possibly reset the immune system. The main goals are to check safety …

This study tests if taking oral sorbitol (a common sugar alcohol) can make standard chemotherapy and immunotherapy work better for people with locally advanced stomach cancer. About 80 adults will receive either sorbitol or a placebo alongside their cancer treatment. The goal is …

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and destroy the faulty cells causing autoimmune blood diseases. The trial includes 27 adults with conditions like immune thrombocytopenia, autoimmune …

This study tests whether adding the drug cadonilimab to standard chemotherapy and radiation can help people with locally advanced cervical cancer live longer without their cancer growing. About 378 women aged 18-70 with stage IIB-IVA cervical cancer will be enrolled. The goal is …

This early-phase study is testing a new treatment called OriV508 for people with multiple myeloma or non-Hodgkin lymphoma that has come back or not responded to standard therapy. The main goals are to check safety and find the right dose. About 40 adults aged 18-75 will take part…

This study is testing a new treatment called IASO208 for people with certain blood cancers (like lymphoma) that have returned or stopped responding to standard therapy. The goal is to see if it is safe and to get an early look at how well it works. About 12 adults aged 18 to 75 w…

This study tests a new combination of three drugs (IN10018, nab-paclitaxel, and cadonilimab) for women with a rare, aggressive cervical cancer that has spread or returned. The goal is to see if the treatment can shrink tumors and control the disease. About 25 adult women who have…

This early-phase study tests a new drug called ZZSW-01 in 6 adults with certain blood cancers (B-cell malignancies) that have returned or not responded to prior treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. Participants w…

This early-phase study tests a new treatment called CT1195E CAR-T cells for people with severe systemic sclerosis (scleroderma) that hasn't responded to other therapies. The therapy uses a patient's own immune cells, modified to attack disease-causing cells. The study aims to fin…

This study looks at people with cirrhosis (scarred liver) who also have severe muscle loss (sarcopenia) and need a procedure called TIPS to treat complications like bleeding. Half will get standard care, and half will also take branched-chain amino acid (BCAA) supplements for 6 m…

This early-stage study tests a new treatment called universal CD19/20 CAR-T cells for people with moderate to severe lupus that hasn't responded to standard therapies. The therapy uses specially engineered immune cells to target and potentially calm the overactive immune system. …

This early study tests a new drug called PRG-1801 in 6 adults with immune thrombocytopenia (ITP) that hasn't improved with standard treatments. The main goal is to check safety and find a safe dose. ITP causes low platelets, leading to bleeding risks, and this treatment aims to r…

This study is for people with newly diagnosed, high-risk rectal cancer. It tests a treatment plan given before surgery that includes a short course of radiation followed by a mix of chemotherapy and immunotherapy. The goal is to shrink or eliminate the tumor so much that some pat…

This study tests whether a procedure called TIPS (a small tube placed in the liver to reroute blood flow) can help people with advanced liver disease (decompensated cirrhosis) achieve 'recompensation'—meaning the liver partially recovers and complications like fluid buildup or bl…

This early study tests a new treatment called CT1182 for adults with B-cell non-Hodgkin lymphoma that has come back or not responded to other therapies. About 24 participants will receive the treatment to see if it is safe and can shrink tumors. The goal is to find the best dose …

This study tests a new medicine called cizutamig in 28 adults with severe rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if it is safe and if it can help control the disease. Participants will receive the drug and be closely monitored for side…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This early study is testing a new imaging agent called FL-261 to see if it can safely and accurately detect and stage several types of cancer, including lung, colorectal, and head & neck cancers. The agent targets a protein (c-MET) found on many cancer cells but not on most healt…

This study is testing a new type of PET scan that looks for a protein called CLDN18.2 on cancer cells. It includes about 56 adults with stomach, pancreatic, bile duct, or esophageal cancers, plus some healthy volunteers. The goal is to see if this scan can accurately find tumors …

This study is testing new types of PET scans to see if they can better find and stage kidney cancer. Researchers will use special tracers that target specific markers on cancer cells. The study involves 66 adults with suspected or confirmed kidney cancer, as well as healthy volun…

This early-stage study is testing a new imaging agent called 68Ga-FL-031 for PET scans to help diagnose and stage several types of cancer, including small cell lung, breast, and nasopharyngeal cancers. Ten adults with confirmed or suspected tumors will receive both the new scan a…

This study tests a new radioactive imaging agent called FL-091 to see how well it can find and stage certain cancers, including head and neck, colorectal, and pancreatic tumors. The agent targets a protein (NTSR1) that is common on these cancer cells but rare on healthy tissue. A…

This study tests whether moxibustion, a traditional Chinese medicine technique that burns herbs near the skin, can help people with severe graft-versus-host disease (GVHD) after a stem cell transplant. About 42 patients who have not responded to steroids will receive standard sec…

This study tests a new medicine called ALT001 for people with knee osteoarthritis. The goal is to see if it can reduce pain, improve movement, and make daily life easier. About 30 adults aged 50 to 75 will receive injections into the knee every two weeks for 12 weeks, and researc…

This study looks at how nutritional health, measured by things like arm circumference and grip strength, relates to the progression of bronchiectasis, a chronic lung condition. Researchers will follow 300 adults over time to track lung function and flare-ups. The goal is to bette…

This study looks at 300 liver cancer patients who cannot have surgery and are receiving a treatment called TACE. Researchers will use artificial intelligence to analyze routine CT scans taken before treatment, measuring body composition to predict survival and treatment outcomes.…

This study aims to understand why bronchiectasis, a chronic lung disease, worsens over time. Researchers will collect sputum, stool, and blood samples from 150 adults and follow them for two years. By analyzing the microbes and chemicals in these samples, they hope to discover wh…

This study compares AI-assisted versus surgeon-planned screw placement in hip fracture surgery. About 334 adults with broken hips will be randomly assigned to one of the two planning methods. The goal is to see if AI can improve screw accuracy, reduce surgery time, and lower comp…

This study looks at whether certain antibodies in the blood can predict if patients with acute viral myocarditis (heart inflammation caused by a virus) will develop dilated cardiomyopathy (a weakened, enlarged heart). Researchers will follow 300 patients over time, measuring thes…

This study looks at why a common liver procedure called TIPS might help people with cirrhosis who have severe muscle loss (sarcopenia). Researchers will measure changes in a protein called FGF21 and muscle mass in 132 adults over one year. The goal is to understand the mechanism,…