Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This study tests whether fecal microbiota transplantation (FMT) can help ICU patients with sepsis. Sepsis is a life-threatening infection that can cause organ failure. The trial will give 60 adults either standard care or standard care plus FMT through a tube into the gut for thr…

This study tests whether fecal microbiota transplantation (FMT) can help critically ill ICU patients who have trouble with tube feeding due to gut problems. Researchers will give 60 patients either standard care plus FMT or standard care alone. They will measure how well the gut …

This early-stage trial tests a new mRNA medicine called IN026 in 16 adults with refractory gout — gout that doesn't get better with standard treatments. The drug is given as an IV infusion and is designed to lower uric acid levels and shrink uric acid crystals (tophi). The main g…

This early-stage study tests a new treatment called LVIVO-TaVec400 in 44 people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard therapies. The main goals are to check the treatment's safety and find the rig…

This study looks at a stem cell transplant from a half-matched donor (haploidentical) combined with drugs to prevent the cancer from coming back. It includes 40 adults aged 18-65 with active AML that has returned or not responded to treatment. The goal is to see if this approach …

This study tests whether fecal microbiota transplantation (FMT) — transferring healthy donor stool into the gut — can lower the risk of death in ventilated ICU patients with multidrug-resistant lung infections. The idea is that restoring gut bacteria may help fight lung infection…

This study tests whether adding a targeted chemoembolization procedure to standard immunotherapy can help people with stage IV lung squamous cell carcinoma live longer without their cancer growing. About 166 participants who have already responded to initial treatment will be ran…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14-50 and measure menstrual recovery six months after transplant. If successful,…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with severe aplastic anemia. The trial will enroll 132 women aged 14–50 and compare menstrual recovery rates six months after transplant…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14 to 50 and measure if their menstrual cycles return naturally within six month…

This study tests whether a combination of three drugs (chidamide, venetoclax, and azacitidine) can help prevent acute myeloid leukemia (AML) from coming back in patients who have already achieved remission. About 104 adults aged 18 to 80 will receive up to 12 cycles of treatment.…

This study tests an AI-powered assistant (Union-Agent) designed to encourage people with chronic hepatitis B who have been diagnosed but not yet treated to start antiviral medication. The study will enroll 2000 adults in China who are eligible for treatment but haven't started. T…

This early-stage trial is testing a new drug called YKST02, given alone or with another drug YK012, in 30 people with active or hard-to-treat lupus. The main goal is to see if the drugs are safe and tolerable. Participants will receive intravenous infusions and be monitored for a…

This study tests whether a short course of radiation followed by three drugs (disitamab vedotin, sintilimab, and capecitabine) can completely eliminate tumors in people with advanced HER2-positive rectal cancer. About 29 adults aged 18-75 will receive the treatment before surgery…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This early-phase trial tests a new gene therapy called QI-019A for people with multiple myeloma that has come back or stopped responding to treatment. The therapy works by turning a patient's own immune cells into cancer-killing cells directly inside the body. The study will enro…

This early-phase trial will test a new type of CAR T-cell therapy, called QT-019C, in 27 adults with refractory immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The therapy uses donor-derived immune cells engineered to targe…

This study tests whether a short course of radiation followed by three cycles of the immunotherapy drug serplulimab plus chemotherapy can help shrink esophageal tumors before surgery. It includes 22 adults with resectable esophageal squamous cell carcinoma. The goal is to see if …

This early-phase study tests a new treatment called RD06-05, a universal CAR-T cell therapy, in 30 adults with moderate-to-severe ulcerative colitis or Crohn's disease who haven't responded to standard treatments. The therapy targets specific immune cells to reduce inflammation i…

This study tests an experimental drug called IBI363 in 35 people with advanced small cell lung cancer that has worsened after at least two prior treatments, including immunotherapy. IBI363 is designed to boost the immune system's ability to attack cancer cells. The main goal is t…

This early-phase trial tests a new cell therapy called YTS109 in 13 adults with autoimmune hemolytic anemia that has not responded to at least three prior treatments. The therapy uses specially engineered immune cells to target and control the disease. The main goals are to check…

This study tests whether adding a special type of radiation (quad shot radiotherapy) to a new immunotherapy drug (QL1706) plus chemotherapy can better control advanced non-small cell lung cancer. About 104 people with stage IV lung cancer that has not been treated yet will take p…

This study tests whether giving two drugs (pembrolizumab and MRG-003) before standard chemoradiation can shrink tumors in people with advanced nasopharyngeal cancer linked to Epstein-Barr virus. About 35 adults with stage III-IVa disease will receive 3 cycles of the drug combo, t…

This study tests penfluridol, a drug originally used for mental health, in 33 adults with small cell lung or cervical cancer that has returned after at least two prior treatments. The goal is to see if the drug can shrink tumors or slow disease progression. Participants take the …

This study tests a three-step treatment for adults with severe immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. Participants first get steroids and a platelet-boosting protein in the hospital, then switch to an oral drug (el…

This phase III trial tests whether adding the immunotherapy drug serplulimab to standard induction chemotherapy can allow patients with advanced nasopharyngeal cancer to skip concurrent chemotherapy during radiation. The study plans to enroll 456 adults aged 18-65 with stage II-I…

This study tests an AI tool called AutoFUSE that helps doctors get better ultrasound images during early pregnancy (11-14 weeks). About 1000 pregnant women will either get the AI-assisted scan or the standard scan. The goal is to see if the AI can save time and improve image qual…

This trial tests whether an artificial intelligence model can help radiologists interpret chest X-rays more accurately and quickly. Researchers will compare diagnoses made with and without AI assistance in 16,000 patients with suspected chest diseases. The goal is to improve the …

This early study will test a special imaging agent that targets a protein found on liver cancer cells. Six people with suspected or confirmed liver cancer will receive a low-dose radioactive tracer and then have a SPECT-CT scan. The goal is to see how the tracer moves through the…

This study tests a new type of PET scan (XH06 PET/CT or PET/MR) to see if it can diagnose liver cancer better than enhanced MRI. About 150 adults with suspected or confirmed liver cancer will get both scans, and results will be checked against tissue samples. The goal is to find …

This study tests a new radioactive imaging agent called 68Ga-NOTA-GPA33 nanobody, which targets a protein (GPA33) found on some cancer cells. Researchers will use PET scans to see if this agent can better detect and stage colorectal, stomach, and pancreatic cancers in 56 patients…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy in people with head and neck cancer. About 156 participants will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if t…

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to start radiation will use either the spray or a placebo for 12 months. The goal is to …

This study tests whether Xiaochaihu Granules, a traditional Chinese herbal medicine, can help with depression in people who have had a stem cell transplant. About 46 patients will receive either a low or high dose of the granules for 100 days, alongside standard care. Researchers…

This study looks at how sepsis affects the bone marrow, where immune cells are made. Researchers will compare bone marrow samples from 45 people: those with sepsis, other critically ill patients, and healthy volunteers. The goal is to understand why sepsis can weaken the immune s…

This observational study will follow 500 people with severe eosinophilic asthma-COPD overlap syndrome (ACOS) who are starting treatment with a biologic drug (benralizumab, mepolizumab, or dupilumab). Researchers will analyze blood exosomes and lung imaging to find markers that pr…

This study will test a new, non-invasive method called EIT Pulse Wave to measure blood flow to the lungs and predict heart stroke volume in critically ill patients. Researchers will compare it to the standard Swan-Ganz catheter, which is invasive. The study involves 19 adults in …

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to find clues …

This study uses artificial intelligence to analyze CT scans, pathology slides, and genetic reports from 1,000 lung cancer patients with EGFR mutations. The goal is to build a model that predicts how well targeted therapy will work after surgery. If successful, it could help docto…

This study will look at tissue samples from 600 people with nasopharyngeal carcinoma to understand how the tumor's immune environment changes over time. The goal is to find markers that predict how well immunotherapy will work and to identify new treatment targets. Participants m…