Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology

This early study tests a new drug called YKST02, given alone or with another drug (YK012), in 30 adults with active or hard-to-treat lupus. The main goal is to see if the treatment is safe and tolerable. Researchers will also look for early signs that it helps control the disease…

This study tests a treatment plan for adults with severe immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding risks. Participants will receive steroids and a platelet-boosting drug in the hospital for 14 days, followed by a 10-we…

This phase 2 trial tests whether giving pembrolizumab (an immunotherapy) plus MRG-003 (a targeted drug) before standard chemoradiation can improve outcomes for people with advanced, EBV-related nasopharyngeal cancer. About 35 participants will receive the combination for 3 cycles…

This study tests an experimental drug called IBI363 in 35 people with advanced small cell lung cancer that has worsened after at least two prior treatments, including immunotherapy. The goal is to see if IBI363 can shrink tumors or slow the disease. Participants will receive the …

This early-phase study tests a new treatment called QT-019C for adults with refractory immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The therapy uses donor-derived CAR T-cells designed to target and remove faulty immune c…

This study tests whether a combination of three drugs (chidamide, venetoclax, and azacitidine) can help prevent acute myeloid leukemia (AML) from returning in patients who have already achieved complete remission after initial treatment. About 104 adults aged 18 to 80 will receiv…

This study tests whether a single injection of goserelin, given before a stem cell transplant, can help preserve ovarian function in women with blood cancers. 64 women aged 14-50 will be randomly assigned to receive goserelin or not. The main goal is to see if more women resume n…

This study tests a new approach for people with resectable esophageal cancer. Before surgery, patients receive a short course of radiation, followed by three cycles of immunotherapy (serplulimab) plus chemotherapy. The goal is to see if this combination can eliminate or shrink th…

This study tests a new immunotherapy drug (QL1706) combined with chemotherapy and a special type of radiation (quad shot) in people with advanced non-small cell lung cancer that has not been treated before. The goal is to see if adding radiation improves tumor shrinkage and delay…

This early study tests a new medicine called IN026 in 16 adults with refractory gout (gout that doesn't get better with standard treatments). The main goal is to check if the injection is safe and to see how the body handles it. Researchers will also measure if it lowers uric aci…

This study tests an intelligent agent (Union-Agent) to help people with chronic hepatitis B who have been diagnosed but haven't started antiviral treatment. The goal is to see if the agent can increase the number of eligible patients who begin treatment within six months. About 2…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancer. Sixty-four women aged 14 to 50 will be randomly assigned to receive either goserelin or no additional treatment. The …

This study tests whether a fecal transplant (FMT) can help ventilated patients with drug-resistant lung infections. The goal is to see if restoring healthy gut bacteria can lower the risk of death within 28 days. The trial will involve 60 adults in the ICU who are on breathing ma…

This early-stage study tests a new treatment called LVIVO-TaVec400 in 44 people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard therapies. The main goals are to check safety and find the right dose. This is…

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the overactive immune system in people with moderate-to-severe ulcerative colitis or Crohn's disease. The study includes up to 30 adults who …

This study tests whether a new drug called serplulimab, given with standard induction chemotherapy, can replace the usual concurrent chemotherapy for people with advanced nasopharyngeal cancer. The goal is to see if this approach works as well or better while reducing side effect…

This study looks at a stem cell transplant from a half-matched donor for adults aged 18-65 with acute myeloid leukemia (AML) that has returned or not responded to treatment. After the transplant, patients receive extra medicines and immune cells to help prevent the cancer from co…

This study tests a new treatment plan for people with advanced rectal cancer that has a protein called HER2. Patients first get a short course of radiation, then a combination of three drugs: disitamab vedotin, sintilimab, and capecitabine. The goal is to see if this approach can…

This study tests penfluridol, a drug originally used for mental health, in 33 adults with advanced small cell lung or cervical cancer that has not responded to at least two prior treatments. The goal is to find a safe weekly dose and see if it can shrink tumors. Penfluridol is ta…

This study tests a combination of two drugs (becotatug vedotin and zimberelimab) in 30 women with cervical, vulvar, or vaginal cancer that has come back or spread. The goal is to see if the treatment can shrink tumors and control the disease. Participants will receive the drugs f…

This early-stage study tests an experimental drug called QI-019A in 24 adults with multiple myeloma that has returned or stopped responding to at least two prior treatments. The main goal is to check the drug's safety and find the right dose, while also looking at how well it wor…

This study tests whether adding a procedure called bronchial artery chemoembolization to standard treatment can help control stage IV lung squamous cell carcinoma. About 166 adults who have already responded to initial chemotherapy and immunotherapy will be randomly assigned to r…

This study tests whether adding metformin (a diabetes drug) to secukinumab (a standard psoriasis medication) works better than secukinumab alone for treating moderate-to-severe plaque psoriasis in overweight or obese Chinese adults. About 186 participants will receive either the …

This study looks at whether a single shot of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with severe aplastic anemia. The trial will enroll 132 women aged 14-50 who are scheduled for a stem cell transplant. Half will receive go…

This early-stage trial tests a new cell therapy called YTS109 for people with autoimmune hemolytic anemia that hasn't improved after three or more treatments. The therapy uses specially designed immune cells to target and destroy the faulty cells attacking red blood cells. The st…

This study tests a new type of PET scan that targets a protein (GPC3) found on liver cancer cells. It will compare this scan with standard MRI in 150 adults suspected of having liver cancer. The goal is to see if the new method is better at finding and staging the cancer, which c…

This early study will test a special imaging agent that targets liver cancer cells. About 6 people with suspected or confirmed liver cancer will receive a low-dose radioactive tracer and then have a SPECT-CT scan. The goal is to see how the tracer moves through the body and wheth…

This study tests whether an artificial intelligence (AI) tool can help radiologists interpret chest X-rays more accurately and quickly. About 16,000 adults with suspected lung conditions like pneumonia or lung cancer will take part. The goal is to see if AI assistance improves di…

This study tests a new type of PET scan that uses a special probe to find cancers that have a protein called GPA33. The study will include 56 people with suspected or confirmed colorectal, stomach, or pancreatic cancer, as well as healthy volunteers. The goal is to see if this im…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy. About 156 adults with head and neck cancer will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if the mouthwash red…

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to receive radiation will use either the spray or a placebo for 12 months. The goal is t…

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why 20-40% also suffer from anxiety or depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and track mood, flare-ups, and hospital visits ov…

This study looks at data from 1,000 lung cancer patients with a specific gene change (EGFR mutation) who received targeted therapy after surgery. Researchers will use artificial intelligence to analyze CT scans, tissue samples, and genetic reports to see if they can predict which…

This study will test if a non-invasive device called EIT Pulse Wave can accurately measure blood flow to the lungs and heart output in critically ill patients with shock or lung injury. Researchers will compare the new method to the standard Swan-Ganz catheter, which requires a t…

This study looks at how the immune system interacts with nasopharyngeal cancer before and after immunotherapy. Researchers will analyze tissue samples from 600 patients to find key cells that predict whether treatment works. They also use advanced techniques to understand why som…