Methodist Health System

This study tested a special stent (Enterprise 2) used with coils to treat wide-neck brain aneurysms. Ten adults with this condition received the procedure. Researchers checked if the stent stayed in place, shortened, or narrowed over time. The goal was to see if this device can s…

This study tested the antibiotic omadacycline in 42 hospitalized adults with diabetic foot infections, some with bone infection. The goal was to see if it causes fewer kidney problems and gut infections compared to standard antibiotics. Researchers compared results to a group of …

This study looked at whether giving one dose of belatacept can delay the start of another drug, tacrolimus, in kidney transplant patients whose new kidneys are slow to start working. The goal was to see if this approach helps the kidneys recover faster and reduces infections. The…

This study looked at whether a drug called sacubitril/valsartan helps African American patients with a certain type of heart failure (reduced ejection fraction). Researchers wanted to see if it lowers the chance of death or hospital visits for heart problems. Over 6,500 African A…

This study tested whether personalized health planning delivered in shared medical appointments could help adults with obesity lose weight. Eleven motivated patients aged 30 to 60 with a BMI between 35 and 50 took part. The approach combined individual health plans with group sup…

This study tested a procedure called selective internal radiation therapy (SIRT) using Y-90 resin microspheres (SIR-Spheres) in one patient with liver cancer that could not be removed by surgery. The goal was to see if a flexible dosing approach could improve outcomes like tumor …

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study looked at 100 liver transplant patients to see if using less immune-suppressing medication could lower the risk of graft-versus-host disease (GVHD), a serious condition where donor cells attack the recipient's body. Researchers tracked how many patients developed GVHD …

This completed study tested facial transplantation in 3 people with severe facial deformities from trauma. The procedure involved transplanting a donor face to improve appearance and quality of life. Participants were followed to measure facial function and overall well-being.

This study looked at a procedure called endoscopic sleeve gastroplasty, which reduces stomach size using a flexible tube through the mouth. 75 adults with obesity who had trouble losing weight with diet and exercise alone took part. The goal was to see how much weight they lost a…

This study tested two stent systems (Neuroform EZ and Neuroform Atlas) used with coils to treat wide-neck brain aneurysms. Wide-neck aneurysms are hard to seal because coils can fall out. The stents act like a scaffold to keep coils in place. 30 adults with unruptured, wide-neck …

This completed study looked at whether a fixed dose of a drug called 4F-PCC is safe and effective for reversing the effects of common blood thinners (rivaroxaban or apixaban) in patients with brain bleeding. Researchers compared this fixed-dose approach to the standard weight-bas…

This study looked at 45 adults on hemodialysis who had a blocked superior vena cava (SVC), a large vein in the chest. Doctors used surgery or a tube-like device to reopen the vein and relieve symptoms. The goal was to improve blood flow and quality of life for these patients.

This study tested a pharmacist-driven protocol to stop stomach ulcer prevention drugs in ICU patients when they are no longer needed. The goal was to reduce unnecessary medication and side effects without increasing the risk of stomach bleeding. The trial included 120 adult ICU p…

This study looked at whether a 1-hour glucose test (using 50 grams of sugar) can accurately diagnose gestational diabetes, so pregnant women might not need the longer 3-hour test. Researchers analyzed results from 351 women with singleton pregnancies who had already completed bot…

This completed study tested a device called NvisionVLE® that helps doctors see bile duct details during a procedure called ERCP. Only 3 adults who had the procedure between 2017 and 2019 took part. The goal was to check if the device is safe and can better find abnormalities to g…

This study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the belly fluid that can be life-threatening. The study included 841 adults with cirrhosis who were at risk f…

This study tested whether a nausea relief inhaler (aromatherapy with essential oils) can reduce post-operative nausea and vomiting in 50 adults after bariatric surgery. The goal was to see if the inhaler could lessen the need for additional nausea medication and improve patient s…

This study tested a procedure called cryoanalgesia, which uses cold to numb nerves, for treating pain from broken ribs. Five adults with rib fractures received the treatment to see if it could improve pain control and reduce the need for strong painkillers. The goal was to find a…

This study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part, answering surveys about their stress, anxiety, and how well they felt they could share decisions with their he…

This study looked back at 500 trauma patients who had a life-saving emergency chest surgery called resuscitative thoracotomy. Researchers wanted to see how often it was used and if there were more cases during the COVID-19 pandemic. The goal was to learn from past practices to im…

This study looked at whether giving antibiotics for 3 days instead of 5 days after facial fracture surgery makes a difference in preventing infections. Researchers enrolled 143 trauma patients to compare the two durations. The goal is to find the shortest effective antibiotic cou…

This completed study looked at 208 people with cerebral aneurysms who were treated with clopidogrel, a blood thinner. Researchers wanted to find out how many patients are overly sensitive to the drug and what happens to them. The goal is to better understand risks and improve car…

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study reviewed medical records of 500 adults treated for benign or malignant pancreatic and stomach diseases from 2005 onward. Researchers looked at overall survival after various treatments. The goal was to understand real-world outcomes, not to test a new drug or procedure…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

This completed study looked at over 4.7 million trauma patients in the U.S. to see if those with liver cirrhosis have higher death rates and more infections. Researchers compared patients with and without cirrhosis using hospital records from 2010 to 2018. The goal was to better …

This study looked at a new method to measure pressure in the liver's blood vessels during an endoscopic ultrasound. Researchers tested it in 100 adults with liver disease to see if it is safe and works well. The goal was to gather information, not to treat the disease.

This study collects and stores medical data from adults who had robotic bariatric surgery between 2018 and 2019. The goal is to build a database that helps doctors understand how well this type of surgery works for weight loss and related health issues. By analyzing real-world ou…

This study looked at whether vitamin D levels affect how well broken bones heal in young adults aged 18 to 25. Researchers measured vitamin D at the time of injury and tracked healing for up to a year. The goal was to understand if low vitamin D is linked to slower healing or com…

This study collected information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to better understand COVID-19 and improve future care, not to test a…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This completed study aimed to compare bleeding risks in emergency surgery patients taking different blood thinners (DOACs, warfarin, or antiplatelets). Only 4 people took part, which is far too few to draw any meaningful conclusions. The results are not useful for guiding treatme…

This completed study looked at the medical records of 8 men diagnosed with breast cancer at Methodist Health System. Researchers wanted to understand their demographics, how their disease progressed, and what complications they faced. Because male breast cancer is very rare, this…

This study examined whether giving ICU patients the same antibiotic they had before, versus a different one, affects the development of drug-resistant bacteria. Researchers looked at 197 adults with Gram-negative infections. The goal was to understand how antibiotic choice impact…

This completed study looked at 945 patients with septic shock to compare two ways of dosing vasopressors (medicines that raise blood pressure): one based on the patient's weight, and one not. The goal was to see which approach leads to better outcomes and fewer side effects, espe…

This study tested a risk prediction tool called ADE-RED, designed to identify emergency department patients at high risk for drug-related hospital readmissions. Researchers followed 471 patients to see if using the tool could reduce repeat visits. The goal is to improve discharge…

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study tracked 69 older adults (age 40 and up) with traumatic brain injury to learn more about their health, frailty, and recovery. Researchers collected data on medications, injuries, and outcomes to find better ways to manage care. No new treatments were tested—the goal was…

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This completed study surveyed 3,000 healthcare workers to understand how often they experience workplace violence, including physical and verbal aggression. The goal was to measure the types of violence, how often it is reported, and its impact on workers' well-being and patient …

This study reviewed the medical records of 504 adults hospitalized with small bowel obstruction to see how using a water-soluble contrast study affected their care. The goal was to find ways to improve patient safety, shorten hospital stays, and reduce complications. Because it i…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study looked at how the COVID-19 pandemic affected the supply of blood products for emergency surgeries at one hospital. Researchers tracked delays and shortages from March 2020 to March 2021. The goal is to use this information to create better policies for handling blood s…

This completed study looked at whether screening hospital patients for multidrug-resistant gram-negative bacteria can predict if they will later develop an infection. Researchers reviewed records of nearly 2,900 adults admitted to an acute care hospital. The goal was to see if ea…

This study created a database of information from nearly 1,000 adult trauma patients with serious arm or leg injuries. Researchers collected details like injury type, treatments, and outcomes to help doctors improve how they save both life and limb. The goal was to learn from pas…

This study tested a training program that uses artificial intelligence to help charge nurses improve their conflict resolution skills. 35 nurses from one hospital completed the program, and their confidence in handling difficult situations was measured. The goal was to support a …

This study tracked 100 fully vaccinated adults to see how many later caught COVID-19 (called a breakthrough infection). It also compared infection rates in people who got a booster shot. The goal was to understand how well vaccines and boosters protect against infection, not to t…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This study looked at how a new U.S. policy for distributing donated livers (started in 2020) affected costs for liver transplants at one hospital in Dallas. Researchers compared costs and transplant volumes for 186 patients before and after the policy change. The goal was to unde…

This study created a large registry of 394 patients who had surgery for an abdominal aortic aneurysm (AAA) in North Texas hospitals. The goal was to track survival, need for repeat surgery, and risk of rupture over time. By collecting this data, doctors hope to improve the qualit…

This study examined medical records of 263 adults with NASH to see how factors like age, other health problems, and medications relate to the severity of liver scarring. The goal was to identify which patients are at higher risk for advanced fibrosis. The findings may help doctor…

This study looked at patient satisfaction surveys from over 1,800 people who visited a neurosurgeon at Methodist Health System between 2016 and 2020. Researchers wanted to see how scores from hospital stays and clinic visits were related. The goal was to find patterns that could …

This completed study placed a full-time chaplain in a primary care clinic to see how often patients and doctors asked for spiritual or emotional support. Researchers tracked what topics patients discussed with the chaplain and tested a way for clinic staff to identify who might b…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study reviewed the medical records of 132 adults in the intensive care unit who had hospital-acquired or ventilator-associated pneumonia caused by Gram-negative bacteria. The goal was to identify risk factors for resistance to common antibiotics. The findings may help doctor…

This study explored whether using personal smartphones for work communication harms work-life balance and increases burnout among nurse managers. Six nurse managers with over 50 staff members each tried new communication strategies. The goal was to see if these tools could reduce…

This study reviewed medical records of 417 adults hospitalized with COVID-19 at four hospitals. Researchers wanted to find out how many patients also had other infections (co-infections) or developed new infections later. They also looked at how these infections affected death ra…

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looked at how emergency pharmacists at one hospital used a special agreement to write prescriptions for patients after they were discharged. The goal was to describe how often and what types of medications were sent to pharmacies. Researchers reviewed records of 350 pa…