Methodist Health System
Clinical trials sponsored by Methodist Health System, explained in plain language.
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Doctors test if less medication can prevent deadly transplant complication
Disease control CompletedThis study looked at whether giving liver transplant patients a lower dose of anti-rejection drugs could help prevent a rare but deadly complication called graft-versus-host disease (GVHD). Researchers followed 100 adult transplant recipients for a year to see if this approach re…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New stent device tested to seal dangerous brain bulges
Disease control CompletedThis study tested a medical device designed to help treat a specific type of brain aneurysm called a 'wide-neck' aneurysm. The device is a small mesh tube (stent) placed in the blood vessel to hold tiny coils inside the aneurysm, aiming to seal it off and prevent rupture. Researc…
Phase: NA • Sponsor: Methodist Health System • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Weighty question: does dosing method affect survival in brain infection?
Disease control CompletedThis study looked back at medical records to see if the way doctors calculate acyclovir doses for obese patients with HSV encephalitis (a serious brain infection) affects survival. Researchers examined 50 patients across six hospitals to compare outcomes when doses were based on …
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Precision radiation dosing tested for tough liver cancers
Disease control CompletedThis study tested a flexible dosing approach for delivering radiation beads (Y90 SIR-Spheres) directly to liver tumors that cannot be surgically removed. Researchers followed one patient to see if adjusting radiation doses based on individual tumor characteristics could improve t…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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ER scorecard aims to stop dangerous drug Mix-Ups
Disease control CompletedThis study tested a new scoring tool designed to help emergency room staff identify patients at high risk for serious medication problems that could send them back to the hospital. The tool flagged patients so a pharmacist could review all their medications before they went home.…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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New antibiotic tested for dangerous diabetic foot infections
Disease control CompletedThis study tested the safety and effectiveness of the antibiotic omadacycline for treating moderate-to-severe diabetic foot infections, sometimes with bone infection. It involved 42 hospitalized patients and compared their outcomes to past patients who received standard antibioti…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Doctors review surgery to unblock Life-Threatening vein in dialysis patients
Disease control CompletedThis study looked back at 45 dialysis patients who had surgery to fix a blocked major chest vein (Superior Vena Cava). The blockage causes dangerous swelling and pressure. Researchers reviewed patient records to see how well the surgery worked to relieve symptoms and keep the vei…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Doctors test group sessions to fight obesity
Disease control CompletedThis small study tested whether group doctor visits could help people with obesity lose weight. Eleven patients attended 90-minute sessions where they created personalized health plans with a medical team. The goal was to see if this group approach was more effective than standar…
Phase: NA • Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Heart Drug's effectiveness in black patients under the microscope
Disease control CompletedThis study aimed to see if a heart failure medication called sacubitril/valsartan works as well for African American patients as it does for others. Researchers followed over 6,500 African American patients with weakened heart pumping to compare outcomes between this drug and sta…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Hospital safety check: are blood thinner doses given correctly?
Disease control CompletedThis study looked at how well hospital staff followed safety rules when giving a common blood thinner called heparin to patients. Researchers reviewed 100 adult patients who needed heparin for serious conditions like blood clots in the legs or lungs, or certain heart problems. Th…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New approach to halt deadly brain bleeds in blood thinner patients
Disease control CompletedThis study tested whether a fixed dose of a drug called 4-factor PCC is safe and effective at stopping brain bleeds in people taking certain blood thinners. It involved 76 adults who had a brain bleed and were taking rivaroxaban or apixaban. Researchers compared a fixed dose to a…
Sponsor: Methodist Health System • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New imaging tool aims to sharpen view of bile duct problems
Diagnosis CompletedThis study tested a specialized imaging system designed to help doctors see bile duct diseases more clearly. It involved three patients who had already undergone a specific bile duct procedure using this system. The goal was to gather more information on whether the system is saf…
Sponsor: Methodist Health System • Aim: Diagnosis
Last updated Mar 27, 2026 12:38 UTC
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Can a fitness tracker get heart patients back on their feet faster?
Symptom relief CompletedThis study tested if giving heart surgery patients a wearable activity monitor (like a fitness tracker) could help them recover more quickly. Researchers wanted to see if tracking their steps would motivate patients to walk more after surgery, helping them return to their normal …
Sponsor: Methodist Health System • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Study tests if work phones can stop nurse burnout
Symptom relief CompletedThis small pilot study explored ways to help nurse managers with large teams improve their work-life balance and reduce burnout. Six managers were split into two groups: one received tips to limit after-hours phone use, and the other got a separate work smartphone. The study meas…
Sponsor: Methodist Health System • Aim: Symptom relief
Last updated Mar 27, 2026 12:37 UTC
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Researchers dig into hospital records to see what else sickens COVID patients
Knowledge-focused CompletedThis study looked back at the medical records of 417 adults hospitalized with COVID-19 in early 2020. The goal was to understand how many patients also had other bacterial or viral infections at the same time or after their COVID diagnosis. Researchers collected this information …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 23:11 UTC
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Researchers dig through medical records to uncover hidden links to severe liver disease
Knowledge-focused CompletedThis study looked back at the medical records of 263 adults with a confirmed liver disease called NASH to see if certain patient characteristics, other health conditions, or medications were linked to more severe liver scarring. Researchers analyzed data from 2013 to 2020 to iden…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 23:11 UTC
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Doctors look back: can a simple scan shorten hospital stays for bowel blockages?
Knowledge-focused CompletedThis study looked back at the medical records of 504 adults treated for a bowel blockage. Researchers wanted to see if using a standard imaging test, called a water-soluble contrast study, as part of a treatment plan led to better and safer care. The goal was to find out if this …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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Researchers track brain injury recovery in seniors
Knowledge-focused CompletedThis study observed 69 patients aged 40+ with confirmed traumatic brain injuries to collect information about their health, treatments, and recovery. Researchers tracked existing medical care without giving any experimental treatments, aiming to identify patterns and best practic…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Hospitals screen for superbugs: does it prevent infections?
Knowledge-focused CompletedThis study looked back at hospital records to see if screening patients for certain hard-to-treat bacteria upon admission could predict who might later get an active infection from those same germs. Researchers analyzed data from nearly 2,900 adult patients to understand if this …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Can artificial intelligence teach nurses to fight less?
Knowledge-focused CompletedThis study tested whether an artificial intelligence (AI) training program could help charge nurses get better at handling workplace conflicts. It involved 35 charge nurses from Methodist Health System. The goal was to see if this training could improve their communication and co…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Weight-Based dosing for shock patients: does size matter?
Knowledge-focused CompletedThis study looked back at medical records to compare two different ways doctors give blood pressure medications to patients with septic shock. Researchers examined whether dosing based on patient weight leads to better or worse outcomes than using standard doses for everyone. The…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Doctors dig through records to uncover why some ICU pneumonias resist treatment
Knowledge-focused CompletedThis study looked back at the medical records of 132 ICU patients who developed pneumonia while in the hospital or on a ventilator. Researchers wanted to understand what factors make these infections resistant to common antibiotics. By analyzing past patient data, the goal was to…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Does weight slow healing? study probes Obesity's role in trauma recovery for seniors
Knowledge-focused CompletedThis study aimed to understand if obesity makes recovery more difficult for older adults after a traumatic injury. Researchers looked back at the medical records of 100 patients aged 60 and older who were hospitalized for injuries. They compared hospital stays, complications, and…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Survey reveals hidden toll of violence on hospital staff
Knowledge-focused CompletedThis study aimed to understand how often healthcare workers experience violence at work and how it affects them. Researchers surveyed 3,000 full-time, part-time, and per diem healthcare employees. The goal was to gather information on the frequency of incidents and their impact o…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Doctors examine what makes neurosurgery patients happy
Knowledge-focused CompletedThis study looked back at patient satisfaction surveys from neurosurgery clinics and hospitals over five years. Researchers analyzed 1,800 surveys to understand how patients rated their care experience, including communication with doctors and overall hospital visits. The goal wa…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Tracking baby health after Mom's emergency surgery
Knowledge-focused CompletedThis study aimed to understand how emergency surgeries, like for appendicitis or gallbladder issues, affect babies when performed on pregnant women. Researchers observed pregnant patients and their newborns to collect information on outcomes, comparing different surgery types and…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Do newer blood thinners cause more bleeding in emergency surgery?
Knowledge-focused CompletedThis study aimed to understand if patients taking newer blood thinners (DOACs) bleed more during emergency abdominal surgery compared to those on older medications like warfarin. It involved a very small group of 4 adult patients who needed urgent surgery. The goal was to gather …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:33 UTC
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New tool aims to spot which older trauma patients are most at risk
Knowledge-focused CompletedThis study aimed to test a new tool called the Trauma Specific Frailty Index (TSFI) to see if it could better predict which older adults (age 65+) are likely to have serious complications or a difficult recovery after a physical injury. Researchers at multiple hospitals observed …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Hospitals ran out of blood during COVID-19: study seeks answers
Knowledge-focused CompletedThis study looked back at what happened to the blood supply in a Dallas hospital during the COVID-19 pandemic. Researchers analyzed data from 100 adult surgical patients to understand why blood products were sometimes delayed for emergencies. The goal is to use this information t…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:27 UTC
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Vaccinated but still got COVID? study investigates why
Knowledge-focused CompletedThis study aimed to understand how often fully vaccinated people still get COVID-19, known as a 'breakthrough infection.' Researchers looked at 100 adults who had received either two mRNA vaccine doses or the single-dose Janssen vaccine, and who later tested positive for COVID-19…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Massive trauma registry aims to save limbs and lives
Knowledge-focused CompletedThis study collected information from 999 adult patients with severe arm or leg injuries to understand how best to control bleeding and save limbs. Researchers looked at hospital records to see how emergency teams used tools like tourniquets and pressure bandages. The goal is to …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC