Johns Hopkins University

This study tests two ways to increase COVID-19 vaccination among Latino adults in Maryland. One group learns motivational interviewing to encourage their friends and family to get vaccinated, while the other group just receives vaccine information. Researchers will compare how ma…

This study tests how well the RSV vaccine Arexvy works in 170 adults with weakened immune systems. Participants will receive up to 3 vaccine doses over a year and be monitored for side effects and immune response. The goal is to find out if one or two doses provide better protect…

This study tests whether providing medically tailored meals and fresh food to Black mothers who recently had gestational diabetes can help them lose weight after childbirth and prevent type 2 diabetes. About 40 low-income women will receive either prepared meals or a mix of prepa…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app, doctor education, and workflow changes to help patients reach their cholesterol goals. Researchers will me…

This study tests whether adding Dysport (a muscle-relaxing injection) to standard bracing can slow or improve spine curvature in teens with scoliosis. About 90 adolescents aged 10-16 with mild to moderate curves will take part. Two-thirds will get Dysport plus a brace; the rest w…

This pilot study tests whether deep brain stimulation (DBS) can help people with severe schizophrenia that hasn't improved with standard treatments, including clozapine. Six adults with persistent hallucinations and delusions will have electrodes placed in a brain region called t…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with psychological support can help 12 adults with cannabis use disorder cut back or stop using cannabis. Participants receive two psilocybin sessions over 12 weeks and are followe…

This study tests a program to help 800 adults in Africa better control their high blood pressure. The program works with patients, doctors, and health systems to lower blood pressure and reduce the risk of heart disease, stroke, and kidney disease. Participants must be 18-70, hav…

This study tests a new way to help adults in Baltimore quit smoking. Participants will use a computer program with an avatar that guides them through quitting, plus get support from a community health worker who can also help arrange lung cancer screening. The study includes 30 p…

This study tests whether metformin, a common diabetes medicine, can improve asthma control in overweight or obese adults whose asthma is not well-controlled by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks and have their asthm…

This study tests a brain implant system that records neural signals and stimulates the brain, aiming to help people with tetraplegia (paralysis from the neck down) control assistive devices like robotic arms using only their thoughts. The trial enrolls 5 participants with C4-C6 s…

This study tests whether adding a person's own concentrated bone marrow cells to standard core decompression surgery can prevent the hip ball from collapsing and reduce pain in people with early-stage osteonecrosis (bone death). About 192 adults with early hip osteonecrosis (stag…

This study looks at the best time to give Hepatitis C (HCV) medication to people without HCV who receive a kidney from a donor with HCV. One group starts the medicine before transplant and takes it for 2 weeks; the other starts after transplant and takes it for 12 weeks. The goal…

This study tests a device that electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness caused by bilateral vestibular hypofunction. Up to 8 adults aged 22-90 will receive the implant, and researchers will measure improvements in …

This study tests a device that electrically stimulates the balance nerve to help older adults (65-90) with chronic dizziness, unsteadiness, and blurry vision due to inner ear damage. The implant aims to improve walking and steadiness. Fifteen participants will be followed for 6 m…

This study is testing a simple, non-invasive method to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach and is pulled back up to collect cell samples. …

This study looks at how a single dose of two F/TAF tablets (a common HIV prevention pill) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if a higher starting dose could improve HIV prevention.

This study tests a new way to prevent HIV among people who inject drugs and their friends. Participants from syringe service programs are trained to share HIV self-test kits, naloxone, and information about PrEP and addiction treatment with their social networks. The goal is to s…

This study tests whether adding an oral drug called tacrolimus before an ERCP procedure can prevent pancreatitis, a painful inflammation of the pancreas that sometimes occurs after the procedure. About 4,800 adults undergoing ERCP will be randomly assigned to receive either the s…

This study looks at whether adding a structured yoga program to usual care can help teenagers with scoliosis feel less back pain and improve their quality of life. About 500 teens aged 10-20 who have not had surgery will take part. Researchers will compare pain, sleep, mood, and …

This study tests a special belt that vibrates to give feedback, helping people with balance problems walk better. Researchers at Johns Hopkins will enroll 90 adults aged 18-80 who have balance disorders, ataxia, or vestibular dysfunction. Participants will wear the belt and perfo…

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can lower the amount of opioid painkillers needed after surgery. The goal is to reduce opioid overprescription and the risk of abuse. About 100 adults having a hysterectomy for …

This study tests whether vestibular therapy—exercises that improve inner-ear balance—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild-to-moderate Alzheimer's and known balance problems will receive either the therapy or a control activity. Res…

This study tests whether a natural hormone called pregnenolone can reverse the effects of cannabis intoxication. Twenty healthy adults who have used cannabis before will receive either pregnenolone or a placebo in random order. Researchers will measure changes in drug effects, th…

This study tests whether psilocybin therapy is feasible and helpful for people with ALS who feel depressed. About 24 adults with ALS will receive psilocybin in a controlled setting. Researchers will track mood, quality of life, and hopelessness over one month.

This study tests a self-administered rehabilitation tool called StableEyes that guides users to gradually increase head movements to reduce motion sickness and improve balance. It is for people with inner ear disorders, including those with vestibular schwannoma or general motion…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) can ease chronic pain, itch, anxiety, sleep problems, and fatigue in adult burn survivors. Some participants will use virtual reality goggles during PMR sessions at home. Researchers want t…

This study tests if entering an MRI machine more slowly can reduce or prevent vertigo and dizziness. Researchers will have 100 people who are already scheduled for an MRI enter the machine at different speeds—ranging from the usual 20 seconds up to 3 minutes—and report any spinni…

This study tests a new mental health program for preschool children from low-income families. About 160 parents and their children, ages 2 to 5, will take part through Head Start programs in Maryland. The program offers virtual sessions to help parents manage their child's behavi…

This study is for people who have shoulder pain after a stroke. It tests if injecting a natural substance called hyaluronic acid into the shoulder muscles can reduce pain and improve movement. About 68 adults who had a stroke 3 months to 15 years ago will take part. The goal is t…

This study aims to understand how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who regularly use them. Researchers will also study how the body processes these products. The goal is to gather information, no…

This study aims to find biological markers in the blood that could help identify women with premenstrual dysphoric disorder (PMDD), a severe form of PMS. Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women—some with PMDD and some …

This study explores whether BCG treatment for non-muscle invasive bladder cancer causes mood changes. About 42 adults will provide blood and urine samples and complete mood questionnaires and daily diaries. The goal is to understand how the treatment affects emotions, not to test…

This study tests a smartphone app designed to teach emergency room patients about hepatitis C (HCV). The app provides personalized information about liver health, HCV knowledge, and steps to get care. Researchers want to see if using the app helps patients understand their condit…

This study tests a program called Heart-to-Heart, where community health workers help low-income heart patients make informed choices about cardiac rehab. Researchers want to see if the program is practical and liked by participants. About 50 adults from Johns Hopkins hospitals w…

This study uses a special eye scan (OCT angiography) to track changes in retinal blood vessel diseases like diabetic retinopathy and vein occlusion. Researchers will compare images from 1,050 people with and without these conditions to find better ways to diagnose disease progres…

This study aims to learn how cerebral small vessel disease (CSVD) develops and worsens over time. Researchers will follow 50 adults who have had a stroke and at least one risk factor like high blood pressure, high cholesterol, or diabetes. Participants will get three MRI scans ov…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts grow and change over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and test results over up to …

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome, where blood flow is cut off. It focuses on sedated ECMO patients who cannot report symptoms. The goal is to see if continuous monitoring helps…

This study is testing a special collar worn around the neck that measures how the body processes radioactive iodine used to treat thyroid cancer and Graves disease. The goal is to see if this device can give doctors better information to personalize the dose for each patient, pot…

This study aims to improve early cancer detection by following 10,000 healthy adults for up to 20 years. Participants provide blood samples and lifestyle information to help researchers identify changes that happen before cancer is diagnosed. The goal is to find better ways to ca…

This study tests if doctors can change normal skin into the thicker, tougher skin found on palms and soles. Researchers take a small skin sample, grow the cells in a lab, and inject them back into the skin. They then check if the skin becomes firmer or changes structure. The stud…

This study gives healthy volunteers psilocybin (the active ingredient in magic mushrooms) and uses brain scans and computer tasks to measure changes in thoughts and brain activity. The goal is to understand how the drug works, not to treat any disease. About 30 adults aged 18-75 …

This study tests the Communities Care program, which aims to change harmful social norms that lead to violence against women and girls. About 3,500 adults and adolescents (ages 10 and older) in Somalia will take part. Researchers will measure changes in violence experiences and b…

This study looks at whether a special drink called exogenous ketones can affect breathing during sleep. Twenty healthy adults will try the drink and a placebo on different nights. The goal is to see if ketones might help with breathing problems like sleep apnea or at high altitud…

This study tests whether sending text messages to first-time fathers, recruited through social media, can help them feel more confident and involved during pregnancy and the first two months after birth. About 180 English-speaking dads-to-be across the U.S. will receive tips and …

This study looks at whether a special parenting program can help 4- and 5-year-olds in public pre-K programs do better in kindergarten. About 840 families from low-income areas in Maryland will take part. Researchers will check children's social skills, behavior, and school atten…

This study aims to find out if very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy people to take at home. Twenty healthy adults will receive increasing doses and a placebo in a controlled lab setting, with close monitoring of …