Johns Hopkins University

This study compares two treatment strategies for people with relapsing-remitting multiple sclerosis (MS): starting with a strong, high-efficacy drug early on versus starting with a milder first-line therapy and switching only if the disease gets worse. The goal is to see which ap…

This study looks at whether having a nurse case manager helps people with multi-drug resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 adults in South Africa are involved. Half of the clinics have a nurse case manager to support patients, while th…

This study tests a program that combines home blood pressure monitors with a smartphone app and support from community health workers. The goal is to help adults with slightly high blood pressure avoid developing more serious hypertension. About 600 participants from community he…

This study planned to test a closed-loop spinal cord stimulator to reduce muscle stiffness (spasticity) and pain in people who had a stroke. It was designed for adults with chronic pain and spasticity lasting more than three months. The study was withdrawn before any volunteers w…

This study tests whether a daily pill called dapagliflozin can prevent heart failure from getting worse in adults with Fontan circulation. About 29 participants will take the drug for 4 weeks to see if it lowers blood pressure in the veins and improves exercise ability. The goal …

This study compares two methods for collecting tissue samples during lung cancer biopsies. Researchers want to see if having a specialist check tissue quality immediately during the procedure helps collect enough material for advanced genetic testing. This genetic testing helps i…

This study looks at whether collecting sexual and medical history through electronic forms during routine gynecologic visits can increase the use of PrEP, a medication that prevents HIV. About 1,170 women aged 15 to 65 who are not living with HIV will take part. The goal is to se…

This study tests a new tool that helps doctors give personalized advice to people with prediabetes. The tool uses a questionnaire to see how ready a person is to make healthy changes, then suggests the best next steps, like a health coach or diabetes prevention program. About 100…

This study enrolls 150 young women aged 13–25 in Baltimore who have pelvic inflammatory disease (PID). Half receive standard care; the other half also get home visits from a community health nurse and text message support for 30 days, plus extra testing and treatment. The goal is…

This early-stage study at Johns Hopkins University is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help reduce symptoms of obsessive-compulsive disorder (OCD). About 35 adults with OCD who have not responded well to prior treatments will receiv…

This study looks at whether using HEPA air purifiers at home can improve asthma symptoms in children ages 8-17. It compares the effect in overweight versus lean children with asthma. About 200 kids from Baltimore City will receive either real or fake air purifiers to see if reduc…

This study tests whether taking a commercially available ketone drink (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use a CPAP machine. Participants will try two different doses and have their blood ketone levels and sle…

This study tests whether an injection of hyaluronidase, a natural enzyme, can reduce muscle stiffness and spasticity in the arm after a stroke. Fifty-six adults who had a stroke 4 months to 15 years ago will receive either the study drug or a placebo, and later switch to the othe…

This study tests whether taking tetracycline for 3 months is tolerable for people who still have Lyme symptoms after standard treatment. 60 adults will receive either the antibiotic or a placebo, then switch after 3 months. The main goal is to see if people can handle the side ef…

This study looks at whether psilocybin, the active ingredient in magic mushrooms, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21 to 65 will receive psilocybin in a controlled setting. Researchers will track changes in mood and dri…

This study tests whether watching a telenovela (a dramatic video series) can lower anxiety and improve confidence for African-American and Hispanic family members caring for hospice patients. About 62 caregivers will either receive the telenovela plus usual hospice care or usual …

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help adults with chronic PTSD who are already on antidepressants. Twenty participants will receive psilocybin therapy, with some also getting trauma-focused talk therapy. The goa…

This study looks at whether the Gracie Diet can improve symptoms of gastroesophageal reflux disease (GERD) in adults who want to stop taking standard acid-reducing medications. Thirty participants will stop their usual pills and follow the diet for 8 weeks. Researchers will track…

This study tests whether a community-based hearing program—using a low-cost over-the-counter device and hearing rehab—can improve communication and quality of life for older Korean Americans (age 60+) and their care partners. 800 participants will be randomly assigned to get the …

This study tests whether listening to specially designed musical patterns and receiving mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disease that causes movement problems. Twenty adults with the condition will be spli…

This study was designed to see if a new ultrasound device with a needle guide could help doctors safely insert needles into the femoral artery during a liver cancer treatment called chemoembolization. The study was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether a computer-delivered alcohol intervention plus help from a community health worker can improve HIV prevention and care for women who drink heavily. About 12 women with or at risk for HIV and who misuse alcohol will take part. The goal is to see if this…

This study aims to find early DNA changes in blood and esophageal tissue that could warn of progression to esophageal cancer. Researchers will follow 600 people with reflux, Barrett's esophagus, or esophageal cancer who are already scheduled for an upper endoscopy. The goal is to…

This study follows 500 people with neurofibromatosis type 1 (NF1) to learn how their skin tumors (cutaneous neurofibromas) grow and change over five years. Researchers use 3D whole-body photography to track tumor number and size. The goal is to better understand these tumors and …

This study looks at whether giving families in rural Congo a youth-friendly economic program (raising rabbits) and a gender equality course for parents can improve the mental health of adolescents aged 10-14. Over 3,000 teens and their parents from 30 villages took part. The goal…

This study aimed to see if giving extra oxygen during sleep could improve blood sugar control in people living at high altitude. It was designed for permanent residents of Puno, Peru, who have sleep-disordered breathing. However, the study was withdrawn before any participants we…

This study was designed to test whether tartrazine, a common food dye, could be applied to the skin to make it temporarily transparent, allowing doctors to see structures underneath without surgery. It was planned for healthy adults, but the trial was withdrawn before any partici…

This study looks at whether muscle twitching during a common neck pain procedure (radiofrequency ablation) can help predict how well the treatment works. Researchers will grade twitching in 60 adults with chronic neck pain and compare it to their pain relief after the procedure. …

This study looks at how information from wearable devices like activity trackers and heart monitors relates to heart and muscle function in people with a type of heart failure called HFpEF, compared to healthy adults. About 60 participants will wear devices for two weeks and unde…

This study looks at whether the type of anesthesia (general vs. neuraxial, like a spinal block) affects the risk of bone cement implantation syndrome (BCIS) in adults having hip fracture surgery. BCIS can cause dangerous drops in blood pressure, breathing problems, and even cardi…

This study tests a program to help doctors decide when to test for lung infections in children on breathing machines. The goal is to reduce unnecessary antibiotics by avoiding tests that may lead to overtreatment. The program involves 15 hospitals and focuses on safely improving …

This study collects information from about 679 adults who have had a procedure called percutaneous cholangiopancreatoscopy (PCPS) to treat bile duct stones, blockages, or certain cancers. The goal is to see how well the procedure works and how many patients can have their drainag…