Magic mushroom compound tested for OCD relief

NCT ID NCT05546658

First seen Nov 01, 2025 · Last updated May 17, 2026 · Updated 20 times

Summary

This early-phase study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help reduce symptoms of obsessive-compulsive disorder (OCD). Thirty-five adults with OCD who have not responded well to standard treatments will receive psilocybin in a controlled setting. Researchers will measure changes in OCD severity, anxiety, depression, and quality of life to see if this approach is worth studying further.

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Contacts and locations

Locations

  • Johns Hopkins University School of Medicine

    Baltimore, Maryland, 21224, United States

Conditions

Explore the condition pages connected to this study.