Johns Hopkins University

This study tested whether evolocumab, a drug that lowers bad cholesterol, can also reduce inflammation and heart damage after a heart attack. 100 adults who recently had a heart attack received either evolocumab or a placebo. The goal was to see if the drug could lower cholestero…

This study tested a computer program called C-Raven that uses a virtual counselor to help people stop smoking. It included 18 adults who smoked daily and were patients at two clinics. The program offered iPad sessions and optional nicotine replacement therapy, plus support from c…

This study tested whether a digital program could help 67 adults with high blood pressure and limited access to healthy food eat better. Participants got a grocery delivery subscription, personalized meal lists, health coaching, and text message support. The main goal was to see …

This study tested two strategies for giving hepatitis C treatment to people who use drugs and are in an opioid treatment program. One group got fast treatment with a peer mentor who had been cured of HCV, while the other group got the usual referral to an outside clinic. The goal…

This study tested a mobile app-based cardiac rehabilitation program for people who recently had a heart attack, heart surgery, or a stent placed. 259 participants were randomly assigned to use the app or attend traditional in-person rehab. The goal was to see if the app could imp…

This study tested whether using air cleaners at home plus motivational coaching to reduce smoking could improve breathing and quality of life for people with COPD who smoke. 144 current smokers with COPD took part. The goal was to see if cleaning indoor air could reduce lung harm…

This study tested a 12-month healthy weight program for 112 youth aged 8-18 with serious emotional disturbance and overweight or obesity. Participants worked with a health coach and their parents to improve diet, physical activity, and weight management. The goal was to reduce bo…

This study tested whether the drug vericiguat can improve the function of small blood vessels in the heart for people with metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and excess belly fat). Forty-five adults completed the trial, which u…

This early-phase study tested whether a radioactive tracer called 11C-PABA can make infections visible on PET scans. Researchers scanned 13 healthy people and patients with known or suspected infections to see if the tracer safely highlights infected areas and helps tell infectio…

This study tested a program where health coaches called pregnant women to help them manage weight gain and prevent problems like gestational diabetes. Over 500 women took part, and the program used phone calls and a website. The goal was to see if this approach could lead to heal…

This study tested whether a registered nurse (RN) could help more women at risk for HIV learn about and start PrEP, a daily pill that prevents HIV. About 440 women in OB/GYN clinics were randomly assigned to either standard care or standard care plus a PrEP-RN who provided counse…

This study tested two medications, roflumilast and azithromycin, to see which one works better at preventing hospitalizations or death in people with severe COPD and chronic bronchitis. Over 1,000 participants took one of the two drugs for up to 72 months. The goal was to find ou…

This pilot study tested whether a program that brings young people and their main sexual partners together for health education is practical and well-liked. 68 participants aged 16-25 and their partners joined counseling sessions to learn about preventing sexually transmitted inf…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower blood sugar as effectively as a program led by a human coach. 368 adults with prediabetes and overweight participated. The goal was to see if the digital approach …

This study tested different non-surgical treatments to reduce pain and improve daily function in 1,937 people with knee osteoarthritis. The goal was to find which treatments work best so patients can avoid relying on opioids. Results will help doctors choose the right treatment f…

This study tested a program called DAPPER for African American women aged 50 and older who had pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study measured changes in pain intensity, depr…

This study tested whether bright light therapy can improve sleep in people with multiple sclerosis (MS). 27 adults with MS and sleep problems used a bright light device to see if it helped them sleep better and feel more rested. The goal was to find a simple, drug-free way to eas…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ spend time with people who have dementia, doing fun and meaningful activities together. The goal was to see if this companionship could reduce loneliness and behavior problems in people with dement…

This study looked at whether a short sleep therapy program (BBTI) could help people with substance use disorders who also have insomnia. About 83 adults living in a residential recovery program took part. They wore sleep trackers, filled out surveys, and did sleep diaries. The go…

This study tested whether dupilumab, an anti-inflammatory drug, can improve symptoms and quality of life in adults with chronic sinusitis who do not have nasal polyps. Thirty-three participants received either dupilumab or a placebo for six months. The main goal was to see if the…

This study looked at how Delta-8 THC affects people compared to Delta-9 THC and a placebo. Healthy adults took the substances by mouth or inhalation, then reported their feelings and completed thinking tests. Researchers also collected blood, saliva, urine, and hair samples to me…

This study tested whether a special radioactive tracer used in PET scans is safe for people with long COVID. Six adults with a history of COVID-19 (some with ongoing symptoms, some without) received the tracer and MRI scans. The goal was to see if the tracer could highlight diffe…

This study tested whether a specially designed stroke unit in Lusaka, Zambia, helps doctors follow best-practice guidelines and improves patient survival. Researchers compared 300 adults with stroke who were treated in the new unit to similar patients treated before the unit exis…

This study looked at how eating dinner early versus late affects metabolism in healthy adults aged 18-30. Researchers timed meals based on each person's natural body clock. Participants ate in the lab and had blood samples taken over 25 hours to measure changes in sugar, fat, and…

This study tested a new radioactive tracer called 18F-FDS to see if it can light up certain bacterial and fungal infections on PET scans. Researchers gave the tracer to 16 people with known or suspected infections and took images to see where it went in the body. The goal was to …

This study looked at how taking oral cannabis (like edibles) along with alcohol affects a person's ability to think clearly and drive safely. Researchers tested 60 healthy adults aged 21-55 using driving simulators, sobriety tests, and thinking tasks. The goal was to understand t…

This pilot study tested a two- to three-month program that teaches liver transplant candidates and a chosen 'champion' how to find a living donor. The program provides education and advocacy training to help patients ask others about donating part of their liver. Researchers meas…

This study followed 300 pregnant women with and without a history of mood disorders to understand why some develop depression or other mood episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to identify risk factors. The goal is to eventu…

This study explored whether hearing and vision loss increase the risk or severity of delirium (sudden confusion) in hospital patients. Over 1,500 adults answered screening questions and had their hearing and vision tested. Researchers also tested if sharing information about comm…

This study tested whether a thin freezing probe (cryoprobe) works better than the usual forceps for taking lung tissue samples during a bronchoscopy. 500 adults scheduled for a standard lung biopsy took part. The main goal was to see which tool more often leads to a clear diagnos…

This study explored how skull base surgery affects a person's sense of smell and taste, and whether a simple smell training program could help them recover faster. Researchers followed 41 adults who had surgery for non-cancerous skull base tumors. They measured smell function and…

This study looked at whether a special training program could help staff at community mental health clinics provide better support for patients who smoke. Researchers worked with 91 clinic staff members to improve their knowledge and confidence in helping patients quit. The goal …

This study looked at the best way to give free fruits and vegetables to adults who are overweight and struggle to afford healthy food. 48 participants were split into two groups: one got weekly vouchers to buy produce, the other got home-delivered boxes tailored to their preferen…

This study looked at how disrupted sleep changes the way painkillers work in the brain and whether it makes them more addictive. Healthy adults aged 18-48 with normal sleep patterns took part in experiments where their sleep was purposely broken up. Researchers measured pain reli…

This study gathered health information from 200 children and young adults with overweight or obesity who were at risk for high blood pressure. Researchers reviewed their medical records to track heart-related data over time. The goal was to better understand how excess weight aff…