One shot of methadone during surgery could slash opioid prescriptions
NCT ID NCT06536517
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. About 100 women with non-cancerous fibroids will be randomly assigned to receive either methadone or standard short-acting opioids during the procedure. The goal is to see if this approach lowers total opioid use in the first week after surgery, helping to prevent overprescription and potential abuse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone
What this could lead to
If it works, this could point toward a way to manage post-surgery pain with fewer opioid pills, lowering the risk of addiction.
What could go wrong
This is a small, early-phase trial (100 people) testing a single dose. Methadone itself is an opioid, so it may not reduce overall opioid use or could cause side effects like nausea or drowsiness.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Johns Hopkins Bayview Medical Center
RECRUITINGBaltimore, Maryland, 21224, United States
Contact
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The Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact