One shot of methadone during surgery could slash opioid prescriptions

NCT ID NCT06536517

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. About 100 women with non-cancerous fibroids will be randomly assigned to receive either methadone or standard short-acting opioids during the procedure. The goal is to see if this approach lowers total opioid use in the first week after surgery, helping to prevent overprescription and potential abuse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone
What this could lead to: If it works, this could point toward a way to manage post-surgery pain with fewer opioid pills, lowering the risk of addiction.
What could go wrong: This is a small, early-phase trial (100 people) testing a single dose. Methadone itself is an opioid, so it may not reduce overall opioid use or could cause side effects like nausea or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyoma uterine corpus leiomyoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROID UTERUS

Contacts and locations

Locations

The Johns Hopkins Bayview Medical Center
RECRUITING

Baltimore, Maryland, 21224, United States
The Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States

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