Scientists unravel the mystery of menstrual cramps and pain relief
NCT ID NCT04145518
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 183 women with menstrual pain to understand why it happens and how naproxen (a common painkiller) relieves it. Using MRI scans, researchers measured uterine activity, blood flow, and oxygen levels before and after taking naproxen or a placebo. The goal is to identify different pain types and improve diagnosis and treatment for dysmenorrhea.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Naproxen Sodium
- What this could lead to
- If successful, this could lead to better diagnosis and personalized treatment for menstrual pain, helping doctors understand why some women respond to naproxen and others do not.
- What could go wrong
- This is a completed Phase 4 study focused on understanding pain mechanisms, not testing a new treatment. The results may not directly change clinical practice or benefit participants immediately.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DYSMENORRHEA (DISORDER) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NorthShore University HealthSystem
Evanston, Illinois, 60201, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can yoga ease the pain of endometriosis after surgery?
- Building a biological treasure trove to decode Women's health mysteries
- Gaming for health: could a video game empower endometriosis patients?
- Can a new formulation of an endometriosis drug match the standard?
- Can a glowing dye reveal a Woman's fertility after ovarian cyst surgery?
- Can we predict endometriosis recurrence and fertility outcomes?