SOLID TUMORS

This is a first-in-human trial testing a new drug called BI-1910, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have worsened after standard treatments. The main goals are to find a safe dose, check for side eff…

This early-stage clinical trial is testing a new experimental drug called RO7247669 in people with advanced solid tumors that have spread. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs that it might help shrink tumors. The …

This study allows patients with solid tumors who were already receiving pertuzumab in a previous Roche trial to continue treatment if they're still benefiting. It tracks how well the treatment controls cancer over the long term and monitors for any side effects. The goal is to pr…

This early-stage study is testing the safety of a new cancer drug called sacituzumab tirumotecan in Japanese patients. The drug is being given alone and in combination with an existing immunotherapy (pembrolizumab) to people with advanced solid tumors or a specific type of advanc…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This is an early-stage study to find a safe dose of a new immunotherapy drug, BI 770371, given alone or with another immunotherapy called ezabenlimab. It is for adults with advanced solid tumors who have no other effective treatment options left. The main goal is to see how much …

This is an early safety study testing a new cancer drug called M9140 in Chinese patients with advanced colorectal cancer that has stopped responding to standard treatments. The trial will enroll 12 participants to check if the drug is safe and to see early signs of whether it mig…

This early-stage study is testing two different pill versions of the same cancer drug, AZD2281, to see if the body absorbs them differently. It involves patients with advanced solid tumors that have not responded to standard treatments. The main goal is to compare the safety and …

This early-stage study is testing the safety and feasibility of new ways to deliver an immune-boosting drug called IMP321 to people with advanced solid tumors. Researchers are trying methods like injecting the drug directly into tumors or into the abdominal cavity, and combining …

This early-stage study is testing a new cell therapy called GK01, given alongside an existing immunotherapy drug, for people with advanced solid tumors that have spread or returned. The main goal is to check if this combination is safe and how the body processes it, while also lo…

This early-stage study is testing the safety of combining two experimental drugs, palbociclib and gedatolisib, for people with advanced cancers that have stopped responding to standard treatments. The main goal is to find the highest dose of this drug combination that patients ca…

This study is testing a new oral drug called ASTX660 in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The main goals are to find the safest and most effective dose and to see if the drug can help control the cancer. The trial i…

This is an early-stage study to check the safety and side effects of a new drug called XmAb24306. It will be tested alone and in combination with an existing immunotherapy drug (atezolizumab) in about 195 adults with advanced solid tumors that have spread or cannot be cured by su…

This is the first human study of an experimental cancer drug called GS-9911. Researchers are testing its safety and finding the right dose when given alone or combined with an immunotherapy drug. The study includes 45 adults with advanced solid tumors who have run out of standard…

This study is testing a drug called entrectinib in children and adolescents with advanced solid tumors or brain cancers that have come back or not responded to other treatments. The main goals are to find the safest and most effective dose and to see if the drug helps shrink tumo…

This early-stage study is testing a new drug called INCB177054, given alone or with an immunotherapy drug, in people with advanced solid tumors that have spread or cannot be cured by surgery. The main goals are to find a safe dose and see if the treatment can shrink tumors. It is…

This is an early-stage study to test the safety and find the right dose of a new drug called JSI-1187. It is being tested alone and in combination with an existing drug, dabrafenib, in adults with advanced solid tumors that have specific genetic changes. The trial is currently su…

This early-stage study is testing the safety and dosing of a new drug called runimotamab. It is being given alone and in combination with an existing cancer drug, trastuzumab, to people with advanced HER2-positive cancers like breast or stomach cancer that have stopped responding…

This is a first-in-human study to test the safety and initial effectiveness of a new drug called INCB186748. It is for adults with advanced or metastatic solid tumors that have a specific genetic change called a KRAS G12D mutation. The main goals are to find a safe dose and see h…

This early-stage study is testing the safety and immune response of a personalized mRNA vaccine called mRNA-4157 in people with solid tumors. The vaccine is being tested alone and in combination with standard treatments like chemotherapy and immunotherapy. The goal is to see if t…

This early-stage trial is testing a new antibody drug called acasunlimab (GEN1046) for people with advanced solid tumors. The study first aims to find safe doses, then tests how well those doses work when given alone or combined with other cancer drugs. All 429 participants will …

This small, early-stage study is testing whether the drug pembrolizumab can prevent cancer from returning in people who have had surgery to remove a solid tumor but still have traces of tumor DNA in their blood. The trial involves about 17 participants who will receive the drug f…

This study tested whether dexamethasone, a common steroid medication, could help control multiple symptoms in patients with advanced cancer. About 132 participants with solid tumors who were experiencing significant symptoms like fatigue, pain, and nausea took either dexamethason…

This study is testing whether the herbal supplement ginseng can help reduce fatigue and improve other symptoms like mood, depression, and anxiety in people with advanced cancer. About 165 participants with cancer and significant daily fatigue will take either ginseng capsules or …

This study aims to understand the long-term safety of gene therapy treatments given to children with cancer. Researchers will follow up to 500 participants for 15 years to monitor for any delayed side effects that might appear months or years after treatment. The study involves r…

This study aims to collect leftover tissue and blood samples from people with cancer who are already having surgery or a biopsy. Researchers will study these samples to better understand cancer and find new targets for future treatments. The study will enroll about 1200 adults an…

This study aims to understand why some cancer patients experience severe or unexpected side effects from their medications. Researchers will collect blood samples from up to 100 patients already enrolled in other NIH cancer trials who are having these bad reactions. By measuring …

This study aims to understand why targeted cancer drugs sometimes stop working. Researchers will collect saliva, blood, and tumor samples from 2500 patients with various solid tumors. They will analyze these samples to identify the genetic patterns that cause resistance to treatm…

This early-phase study aims to understand how taking the antibiotic rifampicin affects how the body processes the experimental cancer drug cediranib. It involves 64 patients with advanced solid tumors that haven't responded to standard treatments. The main goal is to measure drug…

This study follows cancer patients who previously received the immunotherapy drug avelumab in earlier clinical trials. Researchers are tracking long-term safety, side effects, and survival outcomes in about 205 participants with various solid tumors. The goal is to gather extende…

This study aims to find a safe and practical amount of exercise for people to do at home before cancer surgery. It will test different exercise plans using smartphone apps and wearable devices to see what works best. The main goal is to learn if this approach is feasible and how …