NEUROBLASTOMA

This study is testing a new drug called CLR 131 in children and young adults whose cancers have come back or haven't responded to standard treatments. The drug is designed to deliver radiation directly to cancer cells. The main goals are to find a safe dose and see if the drug sh…

This study is testing whether adding two chemotherapy drugs to a standard immunotherapy regimen is safe and feasible for children and young adults with high-risk neuroblastoma. The treatment is given after patients have already completed intensive initial therapy, including stem …

This study is testing a new combination of three drugs for children and young adults whose neuroblastoma has returned or hasn't responded to standard treatments. The main goal is to find the highest dose of a drug called sorafenib that can be safely added to two other chemotherap…

This early-stage study is testing a new combination treatment for children and young adults with advanced osteosarcoma or neuroblastoma that has come back or hasn't responded to standard therapies. Doctors take a patient's own immune cells, genetically modify them to better recog…

This study is testing the safety of combining three different treatments for children whose high-risk neuroblastoma has come back or hasn't responded to other therapies. The goal is to see if using a radioactive medicine (131-I MIBG) along with two immunotherapy drugs (nivolumab …

This study is testing a new treatment plan for babies and young children with a lower-risk form of neuroblastoma, a childhood cancer. The goal is to see if carefully watching certain tumors first, instead of starting chemotherapy right away, is safe and can avoid unnecessary side…

This study tested a new antibody drug (hu14.18K322A) given alongside standard chemotherapy for children with advanced, high-risk neuroblastoma. The goal was to see if adding this antibody, which targets cancer cells, improves treatment response and survival. The trial involved 15…

This study is testing whether a lab-made antibody called Hu3F8, given with an immune-boosting drug (GM-CSF), is safe and effective for treating high-risk neuroblastoma that has come back or resisted standard treatments. It involves about 186 patients, including children over 1 ye…

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose solid tumors have come back or haven't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cance…

This study tested if a fecal microbiota transplant (FMT), which transfers healthy gut bacteria from a donor, could help children with neuroblastoma. It was given alongside standard cancer treatments to see if fixing an imbalance in the child's gut bacteria could improve their res…

This early-stage study is testing a new combination treatment for children and young adults whose neuroblastoma has come back or hasn't responded to standard therapies. Doctors take a patient's own natural killer (NK) immune cells, grow large numbers of them in a lab, and then in…

This study is testing if a standard immunotherapy drug for high-risk neuroblastoma, a serious childhood cancer, can be safely given over a much shorter time. Currently, the drug (dinutuximab) is infused over 10-20 hours for several days, requiring a hospital stay. Researchers wan…

This early-phase study is testing the safety and feasibility of a new treatment called CAR T-cell therapy for children and young adults whose solid tumors have come back or not responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to be…

This early-stage study is testing a new, personalized treatment for children with two aggressive cancers: recurrent neuroblastoma or a newly diagnosed brain stem tumor called DIPG. Doctors create a custom treatment using the patient's own immune cells and tumor material, aiming t…

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…

This study is testing a new radioactive tracer called 18F-DA for PET scans to see if it can create clearer pictures of neuroblastoma and pheochromocytoma tumors than the current standard. Researchers want to check if it's safe and if it goes to the right places in the body. About…

This study is testing a new type of imaging scan to see if it can better identify and map pediatric neuroendocrine tumors, which are rare cancers. Researchers want to know if this new scan helps doctors more precisely target radiation therapy compared to the standard scan current…

This study aims to understand why neuroblastoma, a serious childhood cancer, comes back after treatment. Researchers will analyze tumor samples from children and young adults whose cancer has returned or hasn't responded to therapy. They're looking for specific genetic markers th…

This study aims to understand how a lab-made antibody called Hu3F8 moves through the body and reaches tumors in patients with certain advanced cancers. Researchers will use a special PET scan to track a tiny radioactive tag attached to the antibody. The goal is to gather informat…

This study aims to discover new types of inherited gene changes that might explain why some people develop cancer. Researchers are studying cancer patients along with their unaffected parents to look for gene differences that appear in the child but not the parents. The goal is t…