Engineered t cells take on childhood cancer in early trial
NCT ID NCT01822652
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new type of immune therapy for children with neuroblastoma that has come back or not responded to treatment. Researchers take a patient's own T cells, add new genes to help them recognize and kill neuroblastoma cells and survive longer, then infuse them back. The study also uses chemotherapy and an additional drug (pembrolizumab) to boost the cells' effectiveness. The main goal is to find the safest dose and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
genetically modified T cells (iC9-GD2 T cells) plus chemotherapy (cyclophosphamide and fludarabine) and pembrolizumab
What this could lead to
If successful, this could point toward a more effective treatment for children with hard-to-treat neuroblastoma by helping immune cells survive longer and kill cancer cells.
What could go wrong
This is a very early, small phase 1 trial with only 11 participants, so results may not apply broadly. The modified cells could cause serious side effects, and the treatment may not shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States