New vaccine combo aims to outsmart relapsed neuroblastoma in kids

This study tests a tumor vaccine combined with daily low-dose chemotherapy for children whose high-risk neuroblastoma has returned or not responded to standard treatment. The vaccine is designed to train the immune system to recognize and attack neuroblastoma cells, while the low-dose chemo helps block tumor blood vessels and reduce cells that hide the tumor from the immune system. The main goals are to check safety and see if the treatment can slow or stop the cancer.