Promising combo targets hard-to-treat childhood cancer
NCT ID NCT04301843
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining two drugs, DFMO and etoposide, can help children and young adults (up to age 30) whose neuroblastoma has come back or not responded to standard treatment. About 131 participants will receive the drug combination to see if it delays cancer growth and improves survival. The goal is to find a better option for this aggressive childhood cancer.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alberta Children's Hospital
Calgary, Alberta, AB T3B 6A8, Canada
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Arkansas Children's Hospital
Little Rock, Arkansas, 72202, United States
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Arnold Palmer Hospital for Children
Orlando, Florida, 32806, United States
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Augusta University Health
Augusta, Georgia, 30912, United States
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CHUQ
Québec, Quebec, QC G1V 4W6, Canada
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CIUSSS de l'Estrie-CHUS
Sherbrooke, Quebec, QC J1H 5H3, Canada
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CancerCare Manitoba
Winnipeg, Manitoba, MB R3E 0V9, Canada
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Cardinal Glennon Children's Hospital
St Louis, Missouri, 63104, United States
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Children's Hospital and Clinics of Minnesota
Minneapolis, Minnesota, 55404, United States
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Children's Hospital of The King's Daughters
Norfolk, Virginia, 23507, United States
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Children's Medical Center Dallas
Dallas, Texas, 75235, United States
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Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108, United States
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Cleveland Clinic Children's
Cleveland, Ohio, 44195, United States
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Connecticut Children's Hospital
Hartford, Connecticut, 06106, United States
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Dell Children's Blood and Cancer Center
Austin, Texas, 78723, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hasbro Children's Hospital
Providence, Rhode Island, 02901, United States
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Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
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Levine Children's Hospital
Charlotte, North Carolina, 28204, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Montreal Children's Hospital
Montreal, Quebec, QC H4A 3H9, Canada
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
Louisville, Kentucky, 40201, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
Hershey, Pennsylvania, 17033, United States
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Rady Children's Hospital
San Diego, California, 92123, United States
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Randall Children's Hospital
Portland, Oregon, 97227, United States
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St. Joseph's Children's Hospital
Tampa, Florida, 33614, United States
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UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609, United States
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UHC Sainte-Justine
Montreal, Quebec, QC H3S 2G4, Canada
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University of Alabama/Children's of Alabama
Birmingham, Alabama, 35201, United States
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University of Iowa
Iowa City, Iowa, 52242, United States