Promising combo therapy offers hope for kids with relapsed neuroblastoma
NCT ID NCT04301843
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 36 times
Summary
This study tests whether combining two drugs, DFMO and etoposide, can help children and young adults up to age 30 whose neuroblastoma has returned or not responded to standard treatment. The goal is to see if the combination improves how long participants live without the cancer getting worse. About 131 people will take part across multiple centers.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, AB T3B 6A8, Canada
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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Augusta University Health
RECRUITINGAugusta, Georgia, 30912, United States
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CHUQ
RECRUITINGQuébec, Quebec, QC G1V 4W6, Canada
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CIUSSS de l'Estrie-CHUS
RECRUITINGSherbrooke, Quebec, QC J1H 5H3, Canada
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CancerCare Manitoba
RECRUITINGWinnipeg, Manitoba, MB R3E 0V9, Canada
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Cardinal Glennon Children's Hospital
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Hospital and Clinics of Minnesota
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Children's Hospital of The King's Daughters
RECRUITINGNorfolk, Virginia, 23507, United States
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Children's Medical Center Dallas
RECRUITINGDallas, Texas, 75235, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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Cleveland Clinic Children's
RECRUITINGCleveland, Ohio, 44195, United States
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Connecticut Children's Hospital
RECRUITINGHartford, Connecticut, 06106, United States
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Dell Children's Blood and Cancer Center
RECRUITINGAustin, Texas, 78723, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hasbro Children's Hospital
RECRUITINGProvidence, Rhode Island, 02901, United States
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Helen DeVos Children's Hospital
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Levine Children's Hospital
RECRUITINGCharlotte, North Carolina, 28204, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Montreal Children's Hospital
RECRUITINGMontreal, Quebec, QC H4A 3H9, Canada
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITINGLouisville, Kentucky, 40201, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
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Randall Children's Hospital
RECRUITINGPortland, Oregon, 97227, United States
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St. Joseph's Children's Hospital
RECRUITINGTampa, Florida, 33614, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
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UHC Sainte-Justine
RECRUITINGMontreal, Quebec, QC H3S 2G4, Canada
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University of Alabama/Children's of Alabama
RECRUITINGBirmingham, Alabama, 35201, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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Conditions
Explore the condition pages connected to this study.