Promising combo targets hard-to-treat childhood cancer

NCT ID NCT04301843

Ongoing Disease control Sponsor: Giselle Sholler Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tests whether combining two drugs, DFMO and etoposide, can help children and young adults (up to age 30) whose neuroblastoma has come back or not responded to standard treatment. About 131 participants will receive the drug combination to see if it delays cancer growth and improves survival. The goal is to find a better option for this aggressive childhood cancer.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROBLASTOMA

Contacts and locations

Locations

Alberta Children's Hospital

Calgary, Alberta, AB T3B 6A8, Canada
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Arnold Palmer Hospital for Children

Orlando, Florida, 32806, United States
Augusta University Health

Augusta, Georgia, 30912, United States
CHUQ

Québec, Quebec, QC G1V 4W6, Canada
CIUSSS de l'Estrie-CHUS

Sherbrooke, Quebec, QC J1H 5H3, Canada
CancerCare Manitoba

Winnipeg, Manitoba, MB R3E 0V9, Canada
Cardinal Glennon Children's Hospital

St Louis, Missouri, 63104, United States
Children's Hospital and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507, United States
Children's Medical Center Dallas

Dallas, Texas, 75235, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Cleveland Clinic Children's

Cleveland, Ohio, 44195, United States
Connecticut Children's Hospital

Hartford, Connecticut, 06106, United States
Dell Children's Blood and Cancer Center

Austin, Texas, 78723, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hasbro Children's Hospital

Providence, Rhode Island, 02901, United States
Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Levine Children's Hospital

Charlotte, North Carolina, 28204, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Montreal Children's Hospital

Montreal, Quebec, QC H4A 3H9, Canada
Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine

Louisville, Kentucky, 40201, United States
Penn State Milton S. Hershey Medical Center and Children's Hospital

Hershey, Pennsylvania, 17033, United States
Rady Children's Hospital

San Diego, California, 92123, United States
Randall Children's Hospital

Portland, Oregon, 97227, United States
St. Joseph's Children's Hospital

Tampa, Florida, 33614, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
UHC Sainte-Justine

Montreal, Quebec, QC H3S 2G4, Canada
University of Alabama/Children's of Alabama

Birmingham, Alabama, 35201, United States
University of Iowa

Iowa City, Iowa, 52242, United States

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