MALIGNANT NEOPLASM

This study aims to determine whether delivering focused radiation before surgery works better than after surgery for patients with cancer that has spread to the brain. It will compare two approaches in 180 participants to see which timing is more effective at preventing cancer fr…

This study is testing a new drug called MK-3120 in people with advanced solid tumors that have spread and cannot be removed by surgery. The main goals are to check if the drug is safe and if people can tolerate it, while also seeing if it helps shrink tumors or slow cancer growth…

This trial is testing if a drug called alectinib, already approved for a type of lung cancer, can help treat other rare cancers that share the same genetic change (ALK mutation). It will involve about 30 adults and children with various rare or hard-to-treat cancers. The goal is …

This trial is testing if a drug called capmatinib, already used for some lung cancers, can help adults with rare or uncommon cancers that have specific changes in a gene called MET. The goal is to see if the drug shrinks tumors or provides long-term benefit for these hard-to-trea…

This study is testing a new drug called TSN1611 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The first part aims to find the safest and most effective dose, and the second part will see how well the drug works alone or combined with …

This study is testing a new targeted drug called MK-1084 for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. The main goals are to see if the drug is safe and if it can shrink or eliminate tumors. About 130 participants who hav…

This is a first-in-human study to test the safety and side effects of a new oral drug called MK-4716 for people with advanced solid tumors that have a specific genetic change called a KRAS alteration. The drug will be tested both by itself and in combination with other approved c…

This trial is testing if an existing immunotherapy drug called atezolizumab can help control rare cancers or common cancers with rare genetic features. It will involve about 30 adults and children whose cancers have specific genetic markers. The goal is to see if this approved dr…

This study is testing a new targeted cancer drug called patritumab deruxtecan in children whose liver cancer (hepatoblastoma) or muscle cancer (rhabdomyosarcoma) has returned or hasn't responded to previous treatments. The research aims to find a safe dose for children and see if…

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This study is testing the safety and effectiveness of the drug pembrolizumab in Japanese children with specific solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. Researchers will measure how the body processe…

This study is testing if a safe, injectable fluorescent dye can help surgeons see the edges of bone and soft tissue tumors more clearly during removal surgery. The goal is to help surgeons remove all of the tumor in one operation, which may lower the chance of the cancer coming b…

This trial is testing a refined bone marrow transplant method for people with cancers or other disorders who need a transplant but lack a perfectly matched donor. Doctors use a special machine to select only the most helpful stem cells from a partially matched donor's blood. The …

This study is testing a new cell therapy for people with serious BK or JC virus infections. These viruses can cause severe problems in people with weakened immune systems, such as those with cancer, HIV, or a transplant. Doctors take virus-fighting immune cells from a donor, grow…

This study is testing an experimental drug called MK-5684 for people with advanced breast, ovarian, or endometrial cancers that have progressed after standard treatments. The drug works by blocking the body's production of hormones that can fuel these cancers. Researchers will co…

This study is testing whether using a virtual reality (VR) headset during a single chemotherapy session can help reduce the distress, anxiety, and pain that often come with cancer treatment. 70 adult cancer patients will be randomly assigned to either use VR or choose a standard …

This research study aims to understand how inherited genetic mutations affect cancer risk, development, and treatment response. Researchers will collect blood and saliva samples from 2,000 cancer patients to analyze their DNA. The goal is to identify genetic patterns that could h…

This study aims to develop respectful and culturally appropriate ways to invite American Indians with cancer to participate in genome sequencing research. Researchers will work with tribal communities to understand how genetic changes contribute to higher cancer rates in these po…

This study is creating and testing a new questionnaire system to better understand the symptoms cancer patients experience and how those symptoms impact their daily lives and quality of life. Researchers will enroll thousands of patients, caregivers, and healthcare providers to c…

This study is testing whether data from wearable activity monitors (like Fitbits) can be collected from cancer patients and used by doctors. Researchers want to see if a patient's daily activity levels are connected to their overall health status and survival. The goal is to gath…

This study aims to build an early warning system to predict when cancer patients receiving immunotherapy might develop serious organ damage. Researchers will analyze blood samples and health data from 2000 patients to identify patterns that signal risk before damage occurs. The g…

This study is creating a large registry and tissue bank for children and young adults with cancer. It collects health information and leftover tissue samples from patients up to age 25 to help researchers understand these diseases better. The goal is to use this information to im…

This study is testing different outreach methods to see which ones work best to increase enrollment of African American patients in early-phase cancer treatment trials. It will enroll both patients and their doctors to receive different recruitment approaches or no special outrea…