MALIGNANT NEOPLASM

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This study tests the drug pembrolizumab in Japanese children with solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell skin cancer. The main goals are to check the drug's safety, how the body processes it, and whether tumors shrink. About 20 participants wi…

This study offers a special bone marrow transplant for people with cancer or other serious diseases who lack a perfectly matched donor. Doctors use a device to select only the stem cells from a partially matched donor, removing immune cells that could attack the patient's body. T…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study tests a new drug called patritumab deruxtecan (HER3-DXd) in children whose liver cancer (hepatoblastoma) or muscle cancer (rhabdomyosarcoma) has come back or not responded to treatment. The drug is designed to attach to a protein on cancer cells and deliver a powerful …

This early-phase study tests a new drug called MK-4716, given alone or with other treatments, for people with advanced solid tumors that have a specific KRAS gene change. The main goal is to check the drug's safety and how well people tolerate it. About 250 participants will take…

This study tests a new pill, MK-1084, for people with advanced non-small cell lung cancer that has a specific gene change called KRAS G12C. The drug targets this change to try to shrink or stop the cancer. About 130 participants will receive the drug, and researchers will check f…

This study tests a drug called entrectinib, already approved for certain lung and solid tumors, in people with rare cancers that have a specific genetic change called ROS1 fusion. About 30 adults, teens, and children with these rare cancers will receive the drug. Researchers will…

This study tests alectinib, a drug already approved for some lung cancers, in patients with rare cancers that have an ALK gene change. About 30 adults and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops them from growing. The goal is…

This study tests a new drug called TSN1611 in people with advanced solid tumors that have a specific gene change called KRAS G12D. The study has two parts: first, finding the safest dose, and then seeing how well it shrinks tumors. About 440 adults with various advanced cancers w…

This study tests an experimental oral drug called NBM-BMX in people with advanced solid tumors or newly diagnosed glioblastoma (a type of brain cancer). The drug is given alone to those with solid tumors, or combined with standard treatments (radiation and chemotherapy) for brain…

This study tests a new medicine called MK-5684 that blocks the body from making steroid hormones, which some cancers need to grow. About 250 people with breast, ovarian, or endometrial cancer will receive either MK-5684 or standard treatment. Researchers want to see if MK-5684 he…

This trial tests a drug called atezolizumab, already approved for some cancers, in people with rare cancers that have high numbers of genetic mutations or specific DNA repair problems. About 30 adults and children with these rare tumor types will receive the drug. The main goal i…

This study tests a new drug called MK-3120 in people with advanced solid tumors that have spread and cannot be removed by surgery. The main goal is to see if the drug is safe and tolerable. About 270 adults who have tried all other available treatments will take part.

This study tests whether giving focused radiation before surgery for brain metastases works better than giving it after surgery. The goal is to reduce the chance of cancer spreading in the brain lining and improve local control. About 180 adults with brain metastases will be rand…

This study tests whether a special dye called indocyanine green (ICG) can help surgeons see tumor edges more clearly during bone or soft tissue mass removal. About 100 adults having surgery at Massachusetts General Hospital will receive the dye, and doctors will compare how well …

This study is testing a new type of PET scan that uses a special probe (68Ga-TOI-1) to target a protein called CDH3, which is only found on cancer cells. The goal is to see if this scan can more accurately detect and stage lung cancer compared to the standard PET scan. About 80 a…

This study is creating a large collection of blood, tissue, and health information from 10,000 adults with cancer or at risk for cancer. Researchers will use this data to learn why some cancers respond to treatment and others don't, aiming to make cancer care more personalized. P…

This study is a large registry for children and young adults with cancer. It collects health information and leftover tumor or blood samples over time. The goal is to help doctors find better ways to treat and care for these patients. Up to 75,000 people will take part.

This study is developing and testing a new questionnaire system (called MDASI) to measure common cancer symptoms and how they affect quality of life. Researchers will enroll up to 6,500 participants, including cancer patients, caregivers, and healthcare providers. The goal is to …

This study collects blood, tissue, and bone marrow samples from people with cancer or blood disorders, as well as healthy volunteers. Researchers will use these samples to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. T…

This study aims to find better ways to recruit American Indians from Southwestern tribes for cancer genome sequencing. Researchers want to understand how genetic changes cause cancer in this community, which has higher rates of certain cancers. About 1,000 adults with cancer or s…

This study aims to create an early-warning system that predicts organ damage in cancer patients receiving immune checkpoint inhibitor therapy. Researchers will analyze genetic, protein, and metabolic data from 2,000 participants to identify warning signs of side effects in organs…

This study is looking at the genetic makeup of tumors from 1,100 people with rare or hard-to-treat cancers. By finding specific gene changes, researchers hope to better understand these cancers and identify potential new treatment options. The goal is to improve diagnosis and car…

This study looks at whether using a fitness tracker (like a Fitbit) can give doctors a better picture of how advanced cancer patients are functioning day-to-day. About 590 people with various cancers will wear activity monitors. The goal is to see if the activity data matches up …

This study looks at blood and saliva samples from 2000 cancer patients to understand how inherited gene mutations influence cancer risk, tumor behavior, and response to treatment. Participants must have a confirmed cancer diagnosis and provide consent. The goal is to learn more a…