MALIGNANT NEOPLASM

This study tests a new approach for people with advanced cancers that have not responded to standard treatments. Doctors take a patient's own white blood cells, genetically reprogram them to recognize a protein called NY-ESO-1 found on cancer cells, and give them back along with …

This early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by oxaliplatin chemotherapy in cancer patients. About 56 people with stage I-IV cancer and moderate to severe nerve symptoms will receive either real rTMS, a placebo, or no t…

This study looks at whether using virtual reality (VR) can help reduce pain and anxiety in cancer patients who are getting a bone marrow biopsy or a lumbar puncture. About 60 participants will use VR during the procedure and report their pain and anxiety levels. The goal is to se…

This study looks at whether a pre-surgical toolkit (OPTI-Surg) can improve recovery in older adults with cancer who are having major surgery. The toolkit provides recommendations before surgery to help patients regain physical function faster. About 325 participants will be follo…

This study looks at whether cancer patients can use meditation on their own to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or movement for two weeks. The goal is to see if this approach is practical and helps improve emotional well-bei…

This study tests whether dexamethasone, a steroid, can reduce shortness of breath in people with cancer. About 135 patients with moderate to severe dyspnea and lung involvement will take the drug or a placebo. The main goal is to see if their breathing improves after one week.

This study compares different outreach strategies to see which works best for enrolling African American patients into early-phase cancer treatment trials. About 134 patients and their doctors will take part, with some receiving special outreach and others standard care. The goal…

This study is creating a web-based program to help people with hereditary cancer-causing mutations share their genetic test results with family members. The goal is to increase awareness of cancer risks among at-risk relatives. The program is designed for patients at MD Anderson …

This study examines tumor samples from 170 cancer patients who had an unusually good response to treatment that didn't help most others. Researchers analyze the DNA of these tumors to find genetic changes that might explain why these patients did so well. The goal is to discover …