MALIGNANT NEOPLASM

This early-stage study tested the safety of a new cancer drug called MK-4700, both alone and combined with an existing immunotherapy (pembrolizumab). The trial involved just 5 people with advanced solid tumors that had stopped responding to standard treatments. Researchers measur…

This first-in-human study tested a new experimental drug called HMBD-002, which targets a protein on cancer cells called VISTA. The trial aimed to find a safe dose and schedule for giving HMBD-002 alone and combined with the approved immunotherapy drug pembrolizumab (Keytruda®) i…

This study tested if the simple act of ringing a bell on the final day of radiation therapy could improve how patients remembered the distress of their cancer treatment. It involved 82 people who had completed radiation therapy with curative intent. Researchers compared the memor…

This study tested whether regular phone check-ins and support from care managers could help people with advanced cancer stay mobile and manage pain. Over 500 participants with stage 3 or 4 cancer were assigned to different levels of phone-based support for six months. The goal wa…

This study tested a specialized talk therapy designed to help people with advanced cancer who are experiencing severe emotional distress, anxiety, and feelings of hopelessness. Researchers worked with 24 adult patients to see if this therapy was practical to deliver and if it cou…

This study tested whether taking extra dietary fiber during pelvic radiation therapy for cancer could protect long-term bowel health and reduce inflammation. Over 350 patients were randomly assigned to take either fiber capsules or placebo pills, in addition to following a high-f…

This study tested whether one or two radiation treatments work better for relieving pain from cancer that has spread to bones. Researchers enrolled 102 patients with painful bone metastases and randomly assigned them to receive either one or two radiation sessions. The goal was t…

This early study tested whether a cream containing ketoconazole could reduce the severity of a skin rash caused by a common class of cancer drugs (EGFR inhibitors). 58 patients with cancer who developed this rash were randomly assigned to use either the ketoconazole cream or a pl…

This study tested whether using at-home devices like scales, blood pressure cuffs, and activity trackers could help monitor patients recovering from major cancer surgery. It involved 22 patients with various cancers of the digestive, urinary, or reproductive systems. The goal was…