MALIGNANT NEOPLASM

This early study tested the safety of an experimental drug called MK-4700, given alone or with the approved immunotherapy Keytruda, in 5 people with advanced solid tumors that had stopped responding to other treatments. The main goal was to find a safe dose and see how the body h…

This early-phase study tested a new antibody called HMBD-002, given alone or with pembrolizumab, in 48 adults with advanced solid tumors (like lung or breast cancer) that had stopped responding to standard treatments. The main goals were to check safety, find the best dose, and s…

This study tested a handheld device that uses a single wave to measure how well the heart pumps blood and how stiff the arteries are. Researchers compared it to standard echocardiography in 159 cancer patients. The goal was to see if the device could also help identify patients a…

This study tested whether using a virtual reality headset during chemotherapy can reduce distress, anxiety, and pain. 68 cancer patients were randomly assigned to either use VR for 15–30 minutes or receive standard care. Researchers measured changes in distress and pain scores be…

This study tested a telephone-based collaborative care program for 516 people with stage III or IV cancer. The program included regular check-ins, personalized exercise plans, and help managing treatment side effects. The goal was to see if it could improve mobility, reduce pain,…

This study tested a short-term talking therapy (psychodynamic psychotherapy) for 24 adults with advanced solid tumors and high psychological distress. The goal was to see if the therapy is safe, acceptable, and feasible, not to cure the cancer. Results will help design larger stu…

This study tested whether one dose of radiation works as well as two doses for reducing pain from cancer that has spread to the bones. 102 adults with painful bone metastases took part. The goal was to see if a single treatment could provide similar pain relief and reduce the nee…

This study looked at whether ringing a bell on the last day of radiation therapy helps cancer patients remember their treatment as less distressing. 82 patients took part. Researchers compared distress memory scores between those who rang a bell and those who did not.

This study tested whether ketoconazole, an antifungal drug, can reduce the skin rash caused by EGFR inhibitor cancer therapy. 58 participants with ongoing rash were given either ketoconazole or a placebo. The main goal was to see if the drug improved rash symptoms and quality of …

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study looked at whether it's possible to measure muscle mass and physical function in children (ages 8-21) with newly diagnosed solid tumors or lymphoma during cancer treatment. Researchers used simple tests like a 6-minute walk and a special drink to measure muscle, along w…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…