New hope for kids with tough cancers: targeted drug enters trial

NCT ID NCT06941272

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study is testing a drug called patritumab deruxtecan in children whose liver or muscle cancers have returned or not responded to treatment. The drug works like a smart bomb, attaching to a protein on cancer cells to deliver a toxic payload. The trial will check if it is safe, how the body processes it, and whether it can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: patritumab deruxtecan (HER3-DXd)
What this could lead to: If it works, this could offer a new treatment option for children with certain hard-to-treat cancers that have come back or not responded to standard therapy.
What could go wrong: This is an early-phase trial with only 50 children, so it is not yet known if the drug is safe or effective in this age group. Side effects may be significant, and the cancer may still progress.

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Conditions

The condition(s) this trial relates to.

cancer hepatoblastoma neoplasm rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT NEOPLASM

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aghia Sophia Children's Hospital-First Department of Pediatrics, National and Kapodistrian Universi ( Site 3797)
RECRUITING

Athens, Attica, 11527, Greece
Alberta Children's Hospital ( Site 3227)
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Ankara Bilkent Şehir Hastanesi. ( Site 3962)
RECRUITING

Ankara, 6800, Turkey (Türkiye)
Asan Medical Center-Pediatrics - Pedicatric Oncology ( Site 3973)
RECRUITING

Seoul, 05505, South Korea
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 3102)
RECRUITING

Marseille, Bouches-du-Rhone, 13005, France
Birmingham Children's Hospital ( Site 3349)
RECRUITING

Birmingham, England, B4 6NH, United Kingdom
Bordeaux University Hospital - Pellegrin ( Site 3105)
RECRUITING

Bordeaux, Aquitaine, 33076, France
Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 3104)
RECRUITING

Nantes, Loire-Atlantique, 44093, France
Centre Leon-Berard ( Site 3100)
RECRUITING

Lyon, Rhone, 69373, France
Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 3016)
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia (CHOP) ( Site 3021)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital ( Site 3024)
RECRUITING

Kansas City, Missouri, 64108, United States
Childrens Hospital Los Angeles ( Site 3006)
RECRUITING

Los Angeles, California, 90027, United States
Clinica de la Costa S.A.S. ( Site 3924)
RECRUITING

Barranquilla, Atlántico, 080020, Colombia
Corewell Health ( Site 3001)
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana-Farber Cancer Institute ( Site 3013)
RECRUITING

Boston, Massachusetts, 02215, United States
Detska nemocnice FN Brno ( Site 3388)
RECRUITING

Brno, Brno-mesto, 613 00, Czechia
Ege Universitesi Hastanesi ( Site 3963)
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Fakultni nemocnice v Motole-Klinika detske hematologie a onkologie ( Site 3387)
RECRUITING

Prague, Praha 5, 150 00, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 3552)
RECRUITING

Milan, 20133, Italy
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 3267)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 3264)
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 3961)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hospital Carlos Van Buren ( Site 3880)
RECRUITING

Valparaíso, Valparaiso, 2341131, Chile
Hospital Infantil Universitario Nino Jesus ( Site 3715)
RECRUITING

Madrid, 28009, Spain
Hospital Pablo Tobon Uribe ( Site 3923)
RECRUITING

Medellín, Antioquia, 05034, Colombia
Hospital Sant Joan de Déu ( Site 3717)
RECRUITING

Esplugues de Llobregat, Barcelona, 08950, Spain
Hospital Universitari Vall d''Hebron ( Site 3716)
RECRUITING

Barcelona, 08035, Spain
Hospital de Clinicas de Porto Alegre ( Site 3265)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
IMAT S.A.S ( Site 3921)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Institut Curie ( Site 3101)
RECRUITING

Paris, Île-de-France Region, 75248, France
Intermountain - Primary Children's Hospital ( Site 3014)
RECRUITING

Salt Lake City, Utah, 84113, United States
Johns Hopkins All Children's Hospital ( Site 3025)
RECRUITING

St. Petersburg, Florida, 33701, United States
Memorial Sloan Kettering Cancer Center ( Site 3010)
RECRUITING

New York, New York, 10065, United States
Narodny ustav detskych chorob ( Site 3592)
RECRUITING

Bratislava, Bratislava Region, 831 01, Slovakia
National Taiwan University Hospital ( Site 3983)
RECRUITING

Taiwan, Taipei, 10002, Taiwan
New York Medical College ( Site 3023)
RECRUITING

Valhalla, New York, 10595, United States
Oregon Health and Science University ( Site 3004)
RECRUITING

Portland, Oregon, 97239, United States
Ospedale Infantile Regina Margherita ( Site 3551)
RECRUITING

Torino, 10126, Italy
Ospedale Pediatrico Bambino Gesù IRCCS ( Site 3553)
RECRUITING

Roma, 00165, Italy
Prinses Maxima Centrum voor Kinderoncologie ( Site 3510)
RECRUITING

Utrecht, 3584 CS, Netherlands
Queensland Children's Hospital ( Site 3996)
RECRUITING

Brisbane, Queensland, 4101, Australia
Rambam Health Care Campus ( Site 3674)
RECRUITING

Haifa, 3109601, Israel
Rigshospitalet-Department of paediatrics and adolescent medicine, Section of Paed haem-onc ( Site 3467)
RECRUITING

Copenhagen, Capital Region, DK-2100, Denmark
Royal Children's Hospital ( Site 3994)
RECRUITING

Parkville, Victoria, 3052, Australia
Royal Marsden Hospital ( Site 3347)
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Victoria Infirmary ( Site 3348)
RECRUITING

Newcastle upon Tyne, England, NE1 4PL, United Kingdom
Rutgers Cancer Institute of New Jersey ( Site 3008)
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sahlgrenska Universitetssjukhuset ( Site 3634)
RECRUITING

Gothenburg, Västra Götaland County, 416 85, Sweden
Sanford Children's Hospital ( Site 3015)
RECRUITING

Sioux Falls, South Dakota, 57117, United States
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3003)
RECRUITING

Fargo, North Dakota, 58102, United States
Semmelweis University ( Site 3838)
RECRUITING

Budapest, Pest County, 1094, Hungary
Seoul National University Hospital-Pediatrics ( Site 3972)
RECRUITING

Seoul, 03080, South Korea
Sheba Medical Center ( Site 3675)
RECRUITING

Ramat Gan, 5265601, Israel
Sydney Children's Hospital-Kids Cancer Centre ( Site 3997)
RECRUITING

Sydney, New South Wales, 2031, Australia
The Hospital for Sick Children ( Site 3225)
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
UZ Gent ( Site 3428)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
UniversitaetsklInikum Tuebingen ( Site 3142)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University Hospital of Wales ( Site 3346)
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of Iowa Health Care Holden Comprehensive Cancer Center ( Site 3017)
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas-MD Anderson Cancer Center ( Site 3007)
RECRUITING

Houston, Texas, 77030, United States
Universitätsklinikum Münster - Albert Schweitzer Campus ( Site 3141)
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Yale New Haven Hospital ( Site 3012)
RECRUITING

New Haven, Connecticut, 06510, United States

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