New Hormone-Blocking drug shows promise in cancer trial

NCT ID NCT06979596

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests MK-5684, a drug that blocks the body from making steroid hormones, in people with breast, ovarian, or endometrial cancer. Researchers want to see if it helps patients live longer without their cancer growing compared to standard treatments. The trial is recruiting 250 participants and is currently in Phase 2.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MK-5684 (opevesostat), a drug that blocks steroid hormone production, given with supportive medications like fludrocortisone and dexamethasone.
What this could lead to: If successful, MK-5684 could offer a new treatment option that delays cancer growth in hormone-sensitive solid tumors.
What could go wrong: This is an early Phase 2 trial with only 250 participants, so results may not apply to all patients. Side effects from hormone suppression and added medications are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer endometrioid adenocarcinoma fallopian tube serous adenocarcinoma hormone receptor-positive breast cancer neoplasm ovarian adenocarcinoma ovarian carcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT NEOPLASM

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Alaska Womens Cancer Care ( Site 0037)
RECRUITING

Anchorage, Alaska, 99508, United States
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2201)
RECRUITING

Adana, 01240, Turkey (Türkiye)
Baylor College of Medicine Medical Center ( Site 0004)
RECRUITING

Houston, Texas, 77030, United States
Bradfordhill ( Site 3301)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2003)
RECRUITING

A Coruña, La Coruna, 15006, Spain
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0200)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centro Medico Dr. Doreski - Fundación Respirar ( Site 0302)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Chulalongkorn Hospital ( Site 1114)
RECRUITING

Bangkok, Bangkok, 10330, Thailand
Clinica Universitaria Navarra - Madrid ( Site 2004)
RECRUITING

Madrid, Madrid, Comunidad de, 28027, Spain
Clínica San Antonio ( Site 3404)
RECRUITING

Trujillo, La Libertad, 13008, Peru
FALP ( Site 3300)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Faculty of Medicine Siriraj Hospital ( Site 1111)
RECRUITING

Bangkok, Bangkok, 10700, Thailand
Guy's & St Thomas' NHS Foundation Trust ( Site 2309)
RECRUITING

London, London, City of, SE1 9RT, United Kingdom
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2001)
RECRUITING

Madrid, 28223, Spain
Hacettepe Universitesi ( Site 2200)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Harris Health System ( Site 0040)
RECRUITING

Houston, Texas, 77054, United States
Hospital Aleman ( Site 0301)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1118AAT, Argentina
Hospital Felicio Rocho ( Site 3105)
RECRUITING

Belo Horizonte, Minas Gerais, 30110-934, Brazil
Hospital Santa Rita de Cassia ( Site 3104)
RECRUITING

Vitória, Espírito Santo, 29043-260, Brazil
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2002)
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Hospital de Cancer de Pernambuco ( Site 3103)
RECRUITING

Recife, Pernambuco, 50040-000, Brazil
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3400)
RECRUITING

Lima, 15036, Peru
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2000)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Instituto Alexander Fleming ( Site 0303)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1426ANZ, Argentina
Instituto Nacional de Câncer - INCA ( Site 3107)
RECRUITING

Rio de Janeiro, 20230-130, Brazil
Instituto Nacional de Enfermedades Neoplásicas ( Site 3401)
RECRUITING

Lima, 15038, Peru
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 3405)
RECRUITING

Concepción, Departamento de Junín, 12125, Peru
Istanbul Universitesi Cerrahpasa ( Site 2203)
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Jewish General Hospital ( Site 0201)
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0021)
RECRUITING

Hackensack, New Jersey, 07601, United States
Koc University, School of Medicine ( Site 2202)
RECRUITING

Istanbul, 34450, Turkey (Türkiye)
Liga Norte Riograndense Contra o Cancer ( Site 3108)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Mackay Memorial Hospital ( Site 1002)
RECRUITING

Taipei, 10449, Taiwan
Mary Lanning Healthcare ( Site 0019)
RECRUITING

Hastings, Nebraska, 68901, United States
Mays Cancer Center ( Site 0039)
RECRUITING

San Antonio, Texas, 78229, United States
Mount Sinai Cancer Center ( Site 0009)
RECRUITING

Miami Beach, Florida, 33140, United States
National Cancer Centre Singapore ( Site 0800)
RECRUITING

Singapore, Central Singapore, 168583, Singapore
National Cheng Kung University Hospital ( Site 1003)
RECRUITING

Tainan, 704, Taiwan
ONCOCENTRO APYS ( Site 3302)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Obras Sociais Irma Dulce ( Site 3112)
RECRUITING

Salvador, Estado de Bahia, 41680-430, Brazil
Pantai Hospital Kuala Lumpur ( Site 0603)
RECRUITING

Kuala Lumpur, 59100, Malaysia
Pontificia Universidad Catolica de Chile ( Site 3307)
RECRUITING

Santiago, Region M. de Santiago, 8330032, Chile
Princess Margaret Cancer Centre ( Site 0202)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Queen Elizabeth Hospital ( Site 2305)
RECRUITING

Birmingham, B15 2GW, United Kingdom
Rockefeller Outpatient Pavilion ( Site 0002)
RECRUITING

New York, New York, 10022, United States
Sarawak General Hospital ( Site 0602)
RECRUITING

Kuching, Sarawak, 93586, Malaysia
Songklanagarind Hospital ( Site 1113)
RECRUITING

Songkhla, 90110, Thailand
St Bartholomew's Hospital ( Site 2302)
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom
TRIALS 365 ( Site 0022)
RECRUITING

Shreveport, Louisiana, 71103, United States
Taichung Veterans General Hospital ( Site 1004)
RECRUITING

Taichung, 407, Taiwan
The Christie NHS Foundation Trust ( Site 2300)
RECRUITING

Manchester, M20 4BX, United Kingdom
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0008)
RECRUITING

Columbus, Ohio, 43210, United States
The Royal Cornwall Hospital ( Site 2306)
RECRUITING

Truro, Cornwall, TR1 3LJ, United Kingdom
Trakya Üniversitesi Eğitim Araştırma Hastanesi ( Site 2204)
RECRUITING

Edirne, 22030, Turkey (Türkiye)
University College Hospital London ( Site 2303)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
University Hospitals Sussex NHS Foundation Trust ( Site 2301)
RECRUITING

East Sussex, Brighton And Hove, BN2 1ES, United Kingdom
University Malaya Medical Centre ( Site 0601)
RECRUITING

Kuala Lumpur, 59100, Malaysia
Western General Hospital ( Site 2307)
RECRUITING

Edinburgh, Midlothian, EH4 2XU, United Kingdom

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