New drug MK-4716 targets KRAS cancers in early trial
NCT ID NCT07247110
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing an experimental drug called MK-4716, alone or combined with other cancer drugs, in people with advanced solid tumors that have a KRAS mutation. The main goal is to see if the drug is safe and tolerable. About 250 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-4716 (an experimental drug), pembrolizumab (Keytruda), and cetuximab
What this could lead to
If successful, this could point toward a new treatment option for people with advanced cancers that have a KRAS mutation.
What could go wrong
This is an early Phase 1 trial with only 250 participants, so it is primarily testing safety. The drug may not work or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center ( Site 0502)
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-••••
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Blacktown Hospital ( Site 0455)
RECRUITINGSydney, New South Wales, 2148, Australia
Contact Phone: •••-•••-••••
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Bradfordhill ( Site 0102)
RECRUITINGSantiago, Region M. de Santiago, 8420383, Chile
Contact Phone: •••-•••-••••
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Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0002)
RECRUITINGQuébec, Quebec, G1J 1Z4, Canada
Contact Phone: •••-•••-••••
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Hospital Clinic de Barcelona ( Site 0362)
RECRUITINGBarcelona, 08036, Spain
Contact Phone: •••-•••-••••
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Hospital General Universitari Vall d Hebron ( Site 0360)
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-••••
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Hospital Universitario Fundacion Jimenez Diaz ( Site 0361)
RECRUITINGMadrid, 28040, Spain
Contact Phone: •••-•••-••••
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Monash Health ( Site 0452)
RECRUITINGClayton, Victoria, 3168, Australia
Contact Phone: •••-•••-••••
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NEXT Oncology ( Site 0051)
RECRUITINGIrving, Texas, 75039, United States
Contact Phone: •••-•••-••••
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NEXT Virginia ( Site 0054)
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-••••
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One Clinical Research ( Site 0454)
RECRUITINGNedlands, Western Australia, 6009, Australia
Contact Phone: •••-•••-••••
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Pontificia Universidad Catolica de Chile-CICUC ( Site 0103)
RECRUITINGSantiago, Region M. de Santiago, 8330073, Chile
Contact Phone: •••-•••-••••
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Princess Margaret Cancer Centre ( Site 0001)
RECRUITINGToronto, Ontario, M5G 2M9, Canada
Contact Phone: •••-•••-••••
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Rabin Medical Center ( Site 0253)
RECRUITINGPetah Tikva, 4941492, Israel
Contact Phone: •••-•••-••••
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Rambam Health Care Campus ( Site 0252)
RECRUITINGHaifa, 3109601, Israel
Contact Phone: •••-•••-••••
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Rutgers Cancer Institute of New Jersey ( Site 0052)
RECRUITINGNew Brunswick, New Jersey, 08903, United States
Contact Phone: •••-•••-••••
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Seoul National University Hospital ( Site 0501)
RECRUITINGSeoul, 03080, South Korea
Contact Phone: •••-•••-••••
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Sheba Medical Center ( Site 0251)
RECRUITINGRamat Gan, 5265601, Israel
Contact Phone: •••-•••-••••
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The Alfred Hospital ( Site 0453)
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact Phone: •••-•••-••••