DIABETIC FOOT ULCER

This study looked at whether giving extra education and encouragement to diabetic foot ulcer patients helps them wear their prescribed walking boot more often. The boot is standard care, but many patients don't wear it enough. The study enrolled 18 veterans and measured boot wear…

This early study tested whether injections of cells from donated placentas are safe for people with blocked leg arteries and diabetic foot ulcers. Fifteen adults with diabetes received one of several doses. The main goal was to check for side effects and find the safest dose. Thi…

This study tested a personalized approach using custom-made shoes and inserts to prevent foot ulcers from returning in people with diabetes. 126 adults with a history of foot ulcers were followed for 12 months. The goal was to see if this tailored approach could reduce ulcer recu…

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study followed 191 adults with chronic leg or foot ulcers that hadn't improved for at least 6 months. They received a gel called CACIPLIQ20 added to standard wound care. Researchers tracked how many wounds fully closed within 20 weeks and checked for side effects. The goal w…

This study tested whether a substance from royal jelly, called Royalactin, helps heal diabetic foot ulcers. Ten people with Wagner grade II ulcers received either Royalactin or a placebo applied to their wound three times a week for four weeks. Researchers measured wound size and…

This study tested a special footwear device called OptiPulse™ to see if it helps heal diabetic foot ulcers better than standard care. The device is designed to improve blood flow in the feet. A total of 162 people with diabetic foot ulcers took part in the trial. The main goal wa…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested whether antimicrobial photodynamic therapy (aPDT) can improve wound healing in people with diabetic foot ulcers. Researchers compared wound quality and repair in 94 participants who received either aPDT or a placebo. The goal was to see if this light-based treat…

This completed trial tested whether adding a patient's own skin cells to a standard skin graft helps diabetic foot ulcers heal better. 108 adults with hard-to-heal ulcers received either the cell-enhanced graft or a standard graft alone. The main goal was to see how many wounds f…

This study tested whether applying ozone gas to diabetic foot ulcers helps them heal faster. 430 people with diabetic foot ulcers received either standard wound care plus ozone therapy or standard care alone. The treatment was given every three days for a total of eight sessions.…

This study tested whether a special dressing made from a patient's own platelets (platelet-rich plasma) helps chronic wounds heal better than a standard saline dressing. One hundred adults with long-lasting skin ulcers, including diabetic foot ulcers, took part. The goal was to s…

This study tested a new gel called AUP1602-C on 64 people with diabetes who had foot ulcers that were not healing. The gel was applied directly to the wound and covered with a dressing. The goal was to see if it is safe and helps wounds close faster compared to a placebo gel. The…

This study tested a special wound dressing called Symphony™ against standard care for people with diabetic foot ulcers that won't heal. 143 adults with mild to moderate ulcers took part. The goal was to see if Symphony™ helps more ulcers close completely within 12 weeks and how q…

This study tested whether adding a special placental membrane (BR-AC) to standard wound care helps heal diabetic foot ulcers faster. 71 adults with diabetes and foot ulcers were randomly assigned to get either standard care alone or standard care plus BR-AC. The main goal was to …

This study tested a gel called PEP-TISSEEL, made from platelet-derived particles and a natural sealant, on diabetic foot ulcers. 59 adults with type 1 or 2 diabetes and shallow foot sores were treated for 12 weeks. The goal was to see if the gel helps wounds close safely and fast…

This study tested a new type of dressing for foot ulcers in people with diabetes. 40 adults with a diabetic foot ulcer were split into two groups: one got the new dressing, the other got a standard foam dressing. Everyone also wore a removable offloading boot. The main goal was t…

This study tested a special powder dressing against standard wound care for healing diabetic foot ulcers in 135 adults with diabetes. The powder aims to help wounds close faster. Researchers measured how many ulcers fully healed and how quickly, while also checking for side effec…

This study tested a borate-based bioactive glass wound matrix (Mirragen) plus standard care against standard care alone for diabetic foot ulcers. 148 adults with diabetes and a foot ulcer were enrolled. The main goal was to see if the glass dressing helped more wounds close compl…

This study tested a device that delivers oxygen directly to chronic diabetic foot ulcers to help them heal. 73 people with diabetes and foot sores that had not healed for over a month took part. Half used the real oxygen device, and half used a fake device, while all received sta…

This Phase 3 study tested a sheet of donated stem cells (ALLO-ASC-DFU) on diabetic foot ulcers that have not healed for weeks. 104 adults with type 1 or type 2 diabetes and Wagner grade 2 ulcers were randomly assigned to receive the stem cell sheet or a placebo sheet. The main go…

This study tested a special wound dressing called Restrata Wound Matrix on 30 adults with diabetic foot ulcers. The goal was to see how well it helped wounds close and whether it was safe. Results may guide future research on this treatment.

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study tested whether watching virtual reality (VR) during foot care could lower pain and anxiety in people with diabetic foot ulcers. 64 adults took part, with half using VR and half receiving standard care. Researchers measured pain, anxiety, and vital signs before and afte…

This early-phase study tested a topical gel called BB-101 in 14 adults with diabetic foot or leg ulcers. The goal was to see if the gel is safe and might help wounds heal faster when added to standard care. Participants received either the gel or a placebo, and researchers monito…

This study tested a new method called inforatio to help heal diabetic foot ulcers. The technique involves making small cuts in the wound to trigger the body's natural healing response. 100 adults with diabetes and foot ulcers that had not healed for at least 6 weeks took part. Th…

This study tested a Turkish version of a questionnaire that helps people with diabetes take better care of their feet to prevent ulcers. Researchers interviewed 202 adults with diabetes to see if the tool was accurate and reliable. The tool covers daily foot care, checking for ea…

This study tested whether people with diabetes would use a special foot mat at home every day. The mat, called the Podimetrics SmartMat, measures foot temperature to spot early signs of foot ulcers. Twenty people who had a foot ulcer in the past used the mat for six months. The m…

This study tested whether a rapid DNA sequencing method (mNGS) could better identify bacteria in diabetic foot ulcers compared to standard lab cultures. 44 adults with diabetes and an infected foot ulcer had tissue samples analyzed using both methods. The goal was to see if this …

This study reviewed medical records of 160 people with diabetic foot ulcers who had previously been in a treatment trial. The goal was to understand the total medical costs and rates of amputation linked to these wounds. No new treatments were given; the study simply gathered exi…

This small study looked at how a wound dressing called PHOENIX Wound Matrix changes the bacteria and fungi in chronic diabetic foot ulcers. Eleven adults with diabetes took part. Researchers measured germs and healing markers in the wound before and after treatment to understand …

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This completed study surveyed 179 adults with diabetes in England to understand how environmental factors like job type, lifestyle, and other health conditions affect the risk, severity, and return of diabetic foot ulcers. Participants filled out a 10-15 minute questionnaire, wit…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…