New gel made from platelets shows promise for healing diabetic foot sores

NCT ID NCT06319287

Completed Disease control Sponsor: Rion Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tested a gel called PEP-TISSEEL, made from platelet-derived particles and a natural sealant, on diabetic foot ulcers. 59 adults with type 1 or 2 diabetes and shallow foot sores were treated for 12 weeks. The goal was to see if the gel helps wounds close safely and faster than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PEP-TISSEEL (a gel made from platelet-derived exosomes mixed with a fibrin sealant)
What this could lead to: If successful, this could offer a new topical treatment to help heal diabetic foot ulcers faster and reduce complications.
What could go wrong: This is an early Phase 2a trial with only 59 participants, so results may not apply widely. The treatment is applied topically, but risks like infection or poor healing remain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Diabetic Foot Foot Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC FOOT ULCER

Contacts and locations

Locations

Professional Education & Research Institute (PERI)

Blue Ash, Ohio, 45242, United States

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