APICAL PERIODONTITIS
Clinical trials for APICAL PERIODONTITIS explained in plain language.
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Could your own blood speed up healing after a tooth surgery?
Disease control CompletedThis study tested whether a material made from a patient's own blood, called Leukocyte and Platelet-Rich Fibrin (L-PRF), could help bone and tissue heal better after surgery for a persistent tooth infection. It compared two different surgical techniques, with and without L-PRF, i…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Seyda Ersahan, DDS, PhD • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Tooth healing test: does bigger cleaning work better?
Disease control CompletedThis study tested whether using a larger cleaning size at the tip of a tooth's root leads to better healing after a special regenerative treatment for infected teeth. Researchers compared two different cleaning sizes in 36 adults with infected mature teeth to see which approach r…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Marmara University • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Dental laser fails to show benefit for tooth infections
Disease control CompletedThis study tested whether using a special laser during a root canal could help reduce harmful inflammation in teeth with a chronic root infection. Researchers compared 58 patients who received the laser treatment to those who did not. The results showed the laser treatment was no…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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Blood-Derived gel tested to help heal tooth infections
Disease control CompletedThis study tested if adding an injectable gel made from a patient's own blood (called i-PRF) to a standard root canal procedure could help control a chronic tooth infection. Researchers enrolled 60 patients with this infection and measured specific healing markers in fluid sample…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Better tooth root cleaning? study tests new methods
Disease control CompletedThis study tested whether two advanced cleaning methods—using sound waves (sonic) or high-frequency vibrations (ultrasonic)—help infected tooth roots heal better than the standard needle rinse during a root canal. Researchers treated 42 adults with infected single-rooted teeth, r…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Hilal Çuhadar Beşiroğlu • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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Toothache after root canal? study tests which filling material hurts less
Disease control CompletedThis study tested three different materials used to seal root canals to see if one causes less pain after the procedure and leads to better healing of the bone around the tooth root. 72 adults with a tooth infection received a standard root canal treatment and were randomly assig…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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Scientists attempt to regrow living tissue inside dead teeth
Disease control CompletedThis small, early study tested a new procedure for treating dead, infected teeth. Doctors took healthy pulp tissue from a patient's wisdom tooth and placed it into the cleaned-out root canal of a dead tooth, along with concentrated growth factors from the patient's own blood. The…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Mar 20, 2026 14:47 UTC
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AI helps dentists test simpler alternative to root canals
Disease control CompletedThis study tested whether a simpler, less invasive dental procedure called a full pulpotomy could work as well as a traditional root canal for treating severe tooth pain and inflammation. It involved 58 adults with painful, inflamed back teeth. Researchers also tested how accurat…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Misr International University • Aim: Disease control
Last updated Mar 16, 2026 15:24 UTC
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Zapping root canal pain: can lasers make recovery easier?
Symptom relief CompletedThis study aimed to see if using lasers during a root canal procedure could reduce pain afterward compared to the standard cleaning method. It involved 45 patients with dead tooth nerves who were divided into groups to test different laser and cleaning combinations. Patients trac…
Matched conditions: APICAL PERIODONTITIS
Phase: PHASE2 • Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated Apr 02, 2026 02:12 UTC
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Laser and sonic tools fail to ease root canal pain, study finds
Symptom relief CompletedThis study tested whether using special sonic tools or a laser during root canal treatment could reduce pain afterwards. 80 patients with a specific tooth infection but no pain received one of four cleaning methods. The results showed no significant difference in pain levels or p…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Biruni University • Aim: Symptom relief
Last updated Mar 30, 2026 14:27 UTC
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Dental trial tests which rinse cuts root canal pain best
Symptom relief CompletedThis study compared two antiseptic rinses used at the end of a single-visit root canal procedure to see which one better reduces pain in the first two days after treatment. 142 adults with a specific type of tooth infection received either an octenidine or a chlorhexidine rinse d…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Bezmialem Vakif University • Aim: Symptom relief
Last updated Mar 27, 2026 12:50 UTC
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Could a hidden tooth infection harm your heart?
Knowledge-focused CompletedThis study aimed to understand if a chronic infection at the root of a tooth could affect the health of blood vessels. Researchers compared blood markers in 45 healthy adults, some with this tooth infection and some without, before and after standard dental treatment. The goal wa…
Matched conditions: APICAL PERIODONTITIS
Sponsor: University of Turin, Italy • Aim: Knowledge-focused
Last updated Feb 23, 2026 14:52 UTC