APICAL PERIODONTITIS
Clinical trials for APICAL PERIODONTITIS explained in plain language.
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Tooth pulp transplant with growth factors shows promise in small pilot study
Disease control CompletedThis small pilot study tested whether transplanting a patient's own tooth pulp, combined with concentrated growth factors, could heal dead teeth. Six people with infected, dead teeth received the treatment and were followed for 12 months. The goal was to see if the teeth regained…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated May 17, 2026 03:42 UTC
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Tooth healing study: bigger root prep may boost recovery
Disease control CompletedThis study looked at whether making a larger opening at the tip of the tooth root helps regenerative dental treatment work better for adults with infected mature teeth. 36 people received one of two treatment sizes and were followed for healing and pain. The goal was to see which…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Marmara University • Aim: Disease control
Last updated May 17, 2026 03:41 UTC
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Blood clot breakthrough: natural gel may speed healing after tooth surgery
Disease control CompletedThis study tested whether a natural substance made from a patient's own blood (called L-PRF) can improve bone and gum healing after dental surgery for long-lasting tooth infections. Fifteen adults with infections that didn't go away with standard root canal treatment received sur…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Seyda Ersahan, DDS, PhD • Aim: Disease control
Last updated May 08, 2026 12:02 UTC
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Root canal study reveals best sealers for less pain and faster healing
Symptom relief CompletedThis study looked at 72 adults with infected tooth roots to see if the type of sealer used during root canal treatment changes how much pain they feel and how well the tooth heals. Patients received one of three common sealers, and their pain was checked right after treatment and…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Symptom relief
Last updated May 17, 2026 03:44 UTC
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New tool may ease pain after repeat root canals
Symptom relief CompletedThis study looked at whether using different settings on an electronic device that measures tooth length can reduce pain after a second root canal treatment. 144 adults with infected teeth were treated using either a standard method or one of three special modes. Pain levels were…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Recep Tayyip Erdogan University • Aim: Symptom relief
Last updated May 17, 2026 03:41 UTC
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AI helps dentists save infected teeth without root canals
Symptom relief CompletedThis study tested whether a less invasive dental procedure (full pulpotomy) works as well as a root canal in molars with severe infection. 58 adults with irreversible pulpitis were treated, and an AI tool helped detect hidden infections on X-rays. The goal was to see if the tooth…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Misr International University • Aim: Symptom relief
Last updated May 13, 2026 16:03 UTC
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Root canal rinse showdown: which one hurts less?
Symptom relief CompletedThis study tested two different rinses used at the end of a root canal to see which one leads to less pain afterward. 142 adults with an infected single-root tooth were treated in one visit. They received either octenidine or chlorhexidine as the final rinse. Pain was tracked for…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Bezmialem Vakif University • Aim: Symptom relief
Last updated May 13, 2026 15:58 UTC
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New study tests if sonic or ultrasonic cleaning helps infected teeth heal faster
Symptom relief CompletedThis study looked at 42 adults with infected single-rooted teeth to see if using sonic or ultrasonic tools to clean the root canal helps healing more than standard methods. Participants got one of three cleaning techniques during root canal treatment. The researchers measured cha…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Hilal Çuhadar Beşiroğlu • Aim: Symptom relief
Last updated May 11, 2026 20:40 UTC
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Laser and sonic cleaners fail to ease Post-Root-Canal pain, study finds
Symptom relief CompletedThis study looked at whether using sonic devices (EDDY or EndoActivator) with or without a laser during root canal treatment could lower pain after the procedure. Eighty adults with infected single-root teeth were randomly assigned to one of four cleaning methods. Patients report…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Biruni University • Aim: Symptom relief
Last updated May 07, 2026 18:41 UTC
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Laser root canals may ease Post-Procedure pain
Symptom relief CompletedThis study tested whether using special lasers during root canal treatment reduces pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, and two got different laser treatments. Patients ra…
Matched conditions: APICAL PERIODONTITIS
Phase: PHASE2 • Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated May 01, 2026 15:58 UTC
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New injection may boost tooth infection healing, early study suggests
Knowledge-focused CompletedThis study looked at whether injecting a substance made from a patient's own blood (called i-PRF) into the gums around an infected tooth could improve healing. Sixty adults with chronic tooth infections received standard root canal treatment; half also got the i-PRF injection. Re…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated May 17, 2026 03:43 UTC
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Mind your mouth: study links mental health to tooth infections
Knowledge-focused CompletedThis study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…
Matched conditions: APICAL PERIODONTITIS
Sponsor: University of Siena • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Laser fails to improve tooth infection healing in new study
Knowledge-focused CompletedThis study tested whether using a special laser (Nd:YAG) during root canal treatment could reduce inflammation and stress in infected teeth. Researchers compared 58 patients who received the laser with those who did not. The results showed no significant difference, meaning the l…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Tooth infection may harm blood vessels, new study suggests
Knowledge-focused CompletedThis study looked at whether a chronic tooth infection (apical periodontitis) can cause changes in the blood that might harm blood vessels. Researchers measured inflammation and blood vessel health markers in 45 healthy adults, some with and some without the infection, before and…
Matched conditions: APICAL PERIODONTITIS
Sponsor: University of Turin, Italy • Aim: Knowledge-focused
Last updated May 13, 2026 16:01 UTC