APICAL PERIODONTITIS

This study tests if a less invasive dental treatment called full pulpotomy can heal infected permanent molars as effectively as a root canal. Researchers will treat 128 adults with deep cavities and compare healing in teeth with or without infection at the root tip. Participants …

This study compares a new iron-based nanozyme solution to the standard bleach irrigant for cleaning root canals in adults with infected teeth. Researchers will measure how well each treatment kills bacteria and track bone healing around the tooth root for up to two years. The goa…

This study compares garlic gel to the usual calcium hydroxide paste placed inside a tooth during root canal treatment. Researchers want to see if garlic can reduce pain, swelling, and infection just as well, with fewer side effects and lower cost. About 96 adults with infected si…

This study looks at whether adding other medicines to a standard root canal paste can better kill bacteria in infected teeth. 45 adults with a tooth infection called apical periodontitis will receive one of three pastes during their root canal retreatment. The goal is to find the…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study looks at whether adding platelet-rich fibrin (PRF) — a concentrate from your own blood — to standard root-end surgery helps reduce pain and speed up bone healing. Twenty adults with failed root canals in front teeth or premolars will be treated. Researchers will compar…

This study looks at how well root canal treatments work when done in general dental clinics, not specialist offices. About 1,500 patients who had a root canal in 2023 will get a free check-up after three years to see if the tooth is still infected. The goal is to understand why s…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation. Researchers will measure certain proteins in fluid from the tooth before and a week after cleaning.