ANXIETY DISORDERS

This study tests whether using a person's genetic information to choose psychiatric medications leads to better recovery than standard care. It involves 2,500 adults with mood, anxiety, or psychotic disorders. Participants are randomly assigned to either pharmacogenetics-informed…

This study looks at whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help control tumors better in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 adults will be randomly assigned to get immunother…

This study is testing a brief group therapy called Resilience Training for Teens. The goal is to see if it can prevent serious mental illness in high school students who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens aged 14-19 will take part. The …

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent them from developing a serious mental illness. The study involves 192 students age…

This study tests if a smartphone app called Sidekick can help teenagers with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens aged 13-18 will use the app alongside their usual outpatient treatment. The goal is to see if the app is practical, …

This study looks at whether qigong (a gentle mind-body practice) and multicomponent exercise can improve anxiety, balance, walking, sleep, and quality of life in people with panic disorder. About 60 adults aged 18-65 with a panic disorder diagnosis will participate. The goal is t…

This study looks at whether adding FDA-approved cannabidiol (CBD) to cognitive behavioral therapy (CBT) helps adults with generalized anxiety disorder feel better. About 90 people will take CBD or a placebo alongside therapy sessions. The goal is to see if CBD makes the therapy w…

This study compares two intensive cognitive behavioral therapy formats for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which approach better impr…

This study tests a 4-week mindfulness program for mothers with postpartum anxiety. It aims to reduce anxiety, improve emotion regulation, and increase body awareness using questionnaires and brain scans. The trial enrolls 50 mothers within 12 months of delivery.

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study compares two ways to help people with spider phobia: facing a real spider (in-person exposure) or watching someone else do it over a video call (vicarious exposure). About 72 adults with spider fear will be randomly assigned to one of these groups or a waiting list. Th…

This study tests a non-invasive brain training method called neurofeedback in 56 adults with stable coronary heart disease and anxiety. Participants learn to control a brain region linked to stress while listening to sounds, aiming to lower heart rate and improve heart function. …

This study tests if transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 youth with a doctor's diagnosis will receive TMS treatment. Researchers will measure symptom changes using questionnaires and functioning sc…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This study tests a short online program (about 60 minutes) for people waiting to start face-to-face therapy for anxiety or depression. 312 adults will try different versions of the program to see which works best. The goal is to ease symptoms and improve well-being during the wai…

This study tests a culturally adapted form of cognitive behavioral therapy (CBT) for people living with HIV who also have depression and anxiety. Fifty adults in Peshawar, Pakistan, will either receive six therapy sessions from trained HIV health workers or continue with their us…

This study tests whether a brain-training technique called neurofeedback can help people with stable heart disease and anxiety control their heart rate during stress. About 56 adults will either get real or fake (sham) neurofeedback while their brain activity is monitored. The go…

This study tests a short, 30-minute online program for caregivers of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers want to see if it reduces caregiver anxiety and helps them better support their child.

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to help their teens manage emotions. Researchers want to see if it is practical and helpful for families.

This study tests a brief group therapy designed to help people with anxiety and depression. About 100 adults will be randomly assigned to either the new therapy or standard group therapy. Researchers will measure changes in anxiety and depression symptoms after 3 months to see if…

This study tests a new approach called gaze-contingent music reward therapy (GCMRT) combined with cognitive behavioral therapy (CBT) for children aged 8 to 17 with anxiety disorders. About 150 participants will receive CBT for 4 weeks, then CBT plus either GCMRT or a control task…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests a new therapy called SoundHeal for teens aged 12-18 in juvenile detention who struggle with emotions, anxiety, or substance use. Participants sit in a special room with soothing sounds, music, gentle vibrations, and dim lights, then write about their experience. …

This study tests whether an 8-week Mindful Self-Compassion program can reduce symptoms of anxiety and depression. About 80 adults with diagnosed anxiety disorders or major depression will be randomly assigned to attend the training either in person or via videoconference. The goa…

This study tests a new telehealth program called DINOSAUR for children ages 4 to 6 with autism who also have anxiety. The program uses cognitive-behavioral therapy adapted for young kids to help them handle uncertainty and worry. Researchers will enroll 70 children to see if the …

This study tests if an AI-guided therapy program can help adults with mild depression or anxiety. Participants will either use the AI program or receive standard care for 10 weeks. The goal is to see if AI can make therapy more accessible and reduce symptoms.

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in 128 adults aged 21-55 with anxiety, depression, or PTSD. Participants are randomly assigned to either the active training or a sham version. The goal is t…

This study compares two types of group therapy for adults with anxiety or depression: one fully in-person and one that combines online sessions with in-person meetings. The goal is to see if the blended approach works just as well and is acceptable to participants. About 144 peop…

This study aims to find genetic markers that may predict which children and youth (ages 6–24) with depression, anxiety, or OCD will experience behavioral activation—a side effect like restlessness or agitation—when taking SSRI antidepressants. Researchers will compare the DNA of …

This study screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like interviews, brain scans, and lab tests. The goal is to gather information to better understa…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at how brain function and thinking patterns relate to anxiety in children and teens aged 8 to 17. Researchers will use brain imaging and cognitive tasks to compare anxious youth with healthy peers, and track changes over a year of standard treatments like therapy…

This study explores whether a non-invasive technology called transcranial focused ultrasound (tFUS) can temporarily change how the brain handles emotional situations in people with anxiety disorders. Researchers will measure brain activity and physical responses in 40 adults who …

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to understand diffe…

This study aims to improve MRI scanning techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to develop better tools…

This study looks at whether giving extra money to lower-income parents can improve their children's mental health and brain function. Researchers will follow 500 children whose parents received either a large or small monthly cash supplement for three years. They will measure str…

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study is testing whether an artificial intelligence (AI) tool can reliably measure the severity of depression and anxiety in adults by analyzing video interviews. Researchers will compare the AI's assessments to those made by human clinicians. The goal is to develop a more c…

This study aims to see if brain activity patterns can predict how well people with depression, insomnia, or social anxiety respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will use fMRI scans to measure moment-to-moment brain variability and compare …

This study explores whether a device that temporarily alters brain activity (rTMS) can change how people with anxiety cope with feared situations. Researchers will measure brain responses and behaviors in 80 adults who recently started anxiety treatment. The goal is to gather kno…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation training can help people with mood, anxiety, or impulse disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assigned to …

This study looks at how exercise affects the brain in adults with anxiety disorders. Researchers will measure brain-based markers of energy use and inflammation from blood samples. The goal is to understand the biological reasons why exercise helps reduce anxiety. 30 sedentary ad…

This study looks at whether a non-invasive brain stimulation technique called rTMS can change heart rate in women who have had multiple pregnancy losses and also have anxiety. 55 women will receive different levels of stimulation while their heart activity is recorded. The goal i…