Urinary system disorder
MONDO:0002118A disease involving the renal system.
Also known as: disease of renal system, disease or disorder of renal system, disease, urinary tract, disease, urologic, disease, urological, diseases, urinary tract, diseases, urologic, diseases, urological
5536 clinical trials for this condition and its sub-types, 72 tagged with Urinary system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Urinary system disorder
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Kidney disorder 223 trials · 4,039 incl. sub-types
57 sub-types
- Chronic kidney disease 1,096 trials · 1,571 incl. sub-types Sub-types →
- Kidney failure 236 trials · 1,393 incl. sub-types Sub-types →
- Kidney neoplasm 59 trials · 860 incl. sub-types Sub-types →
- Nephritis 16 trials · 504 incl. sub-types Sub-types →
- Glomerular disorder 9 trials · 482 incl. sub-types Sub-types →
- Inherited kidney disorder 1 trial · 317 incl. sub-types Sub-types →
- Nephrolithiasis 252 trials · 254 incl. sub-types Sub-types →
- Proteinuria 66 trials · 138 incl. sub-types Sub-types →
- Impaired renal function disease 109 trials · 129 incl. sub-types Sub-types →
- Cystic kidney disease 8 trials · 87 incl. sub-types Sub-types →
- Nephrosis 0 trials · 71 incl. sub-types Sub-types →
- Renal infectious disease 16 trials · 64 incl. sub-types Sub-types →
- Renal tubule disorder 1 trial · 47 incl. sub-types Sub-types →
- Diabetes insipidus 34 trials · 38 incl. sub-types Sub-types →
- Renal tubular transport disease 0 trials · 17 incl. sub-types Sub-types →
- Hydronephrosis 7 trials · 9 incl. sub-types Sub-types →
- Stricture or kinking of ureter 9 trials
- Hypertensive nephropathy 8 trials Sub-types →
- Nephrocalcinosis 7 trials · 8 incl. sub-types Sub-types →
- Renal artery disease 3 trials · 7 incl. sub-types Sub-types →
- Fetal lower urinary tract obstruction 0 trials · 6 incl. sub-types Sub-types →
- Congenital primary megaureter 5 trials Sub-types →
- Renal hypertension 0 trials · 4 incl. sub-types Sub-types →
- Distal renal tubular acidosis 3 trials Sub-types →
- Exstrophy-epispadias complex 1 trial · 3 incl. sub-types Sub-types →
- Acute tubulointerstitial nephritis 2 trials
- Kidney cortex necrosis 2 trials
- IgG4-related kidney disease 1 trial
- Anuria 1 trial
- Crush syndrome 1 trial
- Obstructive nephropathy 1 trial
- Orthostatic proteinuria 1 trial
- Renal hypoplasia 1 trial Sub-types →
- Renal nutcracker syndrome 1 trial
- Arnold stickler bourne syndrome 0 trials
- C1q nephropathy 0 trials
- X-linked diffuse leiomyomatosis-Alport syndrome 0 trials Sub-types →
- Atheroembolism of kidney 0 trials
- Atypical Fanconi syndrome-neonatal hyperinsulinism syndrome 0 trials
- Autosomal dominant progressive nephropathy with hypertension 0 trials
- Congenital megacalycosis 0 trials Sub-types →
- Congenital renal artery stenosis 0 trials
- Duplication of urethra 0 trials
- Idiopathic non-lupus full-house nephropathy 0 trials
- Kidney cortex disease 0 trials
- Kidney hypertrophy 0 trials
- Kidney papillary necrosis 0 trials Sub-types →
- Lachiewicz sibley syndrome 0 trials
- Neonatal renal venous thrombosis 0 trials
- Non-syndromic supernumerary kidneys 0 trials
- Oligomeganephronia 0 trials
- Perinephritis 0 trials
- Pyonephrosis 0 trials
- Renal aminoaciduria 0 trials
- Renal dysplasia 0 trials Sub-types →
- Renal tubular dysgenesis 0 trials Sub-types →
- Tubulointerstitial nephritis and uveitis syndrome 0 trials
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Urinary system neoplasm 21 trials · 1,694 incl. sub-types
8 sub-types
- Malignant urinary system neoplasm 75 trials · 1,668 incl. sub-types Sub-types →
- Kidney neoplasm 59 trials · 860 incl. sub-types Sub-types →
- Urinary bladder neoplasm 65 trials · 703 incl. sub-types Sub-types →
- Urothelial neoplasm 2 trials · 696 incl. sub-types Sub-types →
- Benign urinary system neoplasm 50 trials · 62 incl. sub-types Sub-types →
- Ureter neoplasm 2 trials · 34 incl. sub-types Sub-types →
- Urethra neoplasm 3 trials · 31 incl. sub-types Sub-types →
- Prostate phyllodes tumor 0 trials Sub-types →
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Urinary bladder disorder 24 trials · 1,158 incl. sub-types
17 sub-types
- Urinary bladder neoplasm 65 trials · 703 incl. sub-types Sub-types →
- Overactive bladder 168 trials
- Female stress incontinence 138 trials
- Cystitis 12 trials · 72 incl. sub-types Sub-types →
- Ureterolithiasis 49 trials
- Bladder neck obstruction 12 trials
- Bladder calculus 6 trials Sub-types →
- Hinman syndrome 5 trials
- Vesicoureteral reflux 5 trials Sub-types →
- Detrusor sphincter dyssynergia 3 trials
- Urinary schistosomiasis 3 trials
- Low compliance bladder 2 trials
- Postcholecystectomy syndrome 1 trial
- Bladder diverticulum 0 trials Sub-types →
- Disorder of neck of urinary bladder 0 trials Sub-types →
- Ureterocele 0 trials
- Urinary bladder tuberculosis 0 trials
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Urolithiasis 120 trials · 313 incl. sub-types
2 sub-types
- Nephrolithiasis 252 trials · 254 incl. sub-types Sub-types →
- Lower urinary tract calculus 0 trials · 6 incl. sub-types Sub-types →
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Urinary tract infection 156 trials · 250 incl. sub-types
5 sub-types
- Bacterial urinary tract infection 55 trials · 81 incl. sub-types Sub-types →
- Renal infectious disease 16 trials · 64 incl. sub-types Sub-types →
- Trichomonas vaginitis urogenital infection 7 trials Sub-types →
- Urinary schistosomiasis 3 trials
- Pyoureter 0 trials
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Ureteral disorder 2 trials · 95 incl. sub-types
8 sub-types
- Ureterolithiasis 49 trials
- Ureter neoplasm 2 trials · 34 incl. sub-types Sub-types →
- Ureteral obstruction 9 trials
- Vesicoureteral reflux 5 trials Sub-types →
- Pyoureter 0 trials
- Ureter tuberculosis 0 trials
- Ureteritis 0 trials
- Ureterocele 0 trials
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Urethral disorder 1 trial · 70 incl. sub-types
10 sub-types
- Urethra neoplasm 3 trials · 31 incl. sub-types Sub-types →
- Urethral obstruction 3 trials · 26 incl. sub-types Sub-types →
- Urethritis 5 trials · 6 incl. sub-types Sub-types →
- Urethral syndrome 4 trials
- Urethral intrinsic sphincter deficiency 3 trials
- Fibroepithelial polyp of urethra 0 trials
- Prolapse of urethra 0 trials
- Urethral calculus 0 trials
- Urethral false passage 0 trials
- Urethral gland abscess 0 trials
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Urinary tract obstruction 12 trials · 27 incl. sub-types
2 sub-types
- Hydronephrosis 7 trials · 9 incl. sub-types Sub-types →
- Ureteral obstruction 9 trials
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Bacteriuria 11 trials
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Idiopathic hypercalciuria 3 trials
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Paraneoplastic renal syndrome 0 trials · 3 incl. sub-types
1 sub-type
- Oncogenic osteomalacia 3 trials
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Congenital urachal anomaly 0 trials
4 sub-types
- Patent urachus 0 trials
- Urachal cyst 0 trials
- Urachal diverticulum 0 trials
- Urachal sinus 0 trials
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Hypercalciuria, absorptive, 1 0 trials
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Hypercalciuria, absorptive, 2 0 trials
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Hyperglycinuria 0 trials
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Megacystis-megaureter syndrome 0 trials
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Meningitis-retention syndrome 0 trials
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Postorgasmic illness syndrome 0 trials
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Pyuria 0 trials
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Urothelial hyperplasia 0 trials
2 sub-types
- Flat urothelial hyperplasia 0 trials
- Papillary urothelial hyperplasia 0 trials
Most studied deeper sub-types
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New drug trial aims to protect Kids' kidneys from IgA nephropathy
Disease control Recruiting nowThis phase 3 trial tests the drug atrasentan in 28 children aged 2 to 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The study measures whether atrasentan reduces protein in the urine, a sign of kidney damage, over 36 weeks. All participants receive th…
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Sep 21, 2026 21:00 UTC
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New drug combo may help bladder cancer patients keep their bladder
Disease control Recruiting nowThis study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will receive either the drug combo or standard chemoradiatio…
Phase 3 • Sponsor: Astellas Pharma Global Development, Inc. • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New hope for chronic UTI sufferers: extended antibiotic combo trial launches
Disease control Recruiting nowThis phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …
Phase 2 • Sponsor: University College, London • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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New exercise combo aims to help kids stop wetting themselves
Disease control Recruiting nowThis study tests whether adding a special exercise method (dynamic neuromuscular stabilization) to standard pelvic floor training helps children with voiding dysfunction. About 48 children aged 5-18 will be randomly assigned to standard training or the combined program for 10 wee…
Sponsor: Necmettin Erbakan University • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New hope for kidney disease: JADE101 trial launches
Disease control Recruiting nowThis study tests a new drug, JADE101, in 30 adults with IgA nephropathy, a kidney disease. The goal is to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Participants must be on stable standard care and have a kidney biopsy confirming the dis…
Phase 2 • Sponsor: Jade Biosciences, Inc. • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Water jet surgery: a new wave for prostate relief?
Disease control Recruiting nowThis trial is testing aquablation, a procedure that uses a robotically guided high-pressure water jet to remove excess prostate tissue in men with benign prostatic hyperplasia (BPH), a common cause of urinary problems. The study will enroll 25 Canadian men who are candidates for …
Sponsor: Can-Am HIFU Inc. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Steam therapy for enlarged prostate: a new hope?
Disease control Recruiting nowThis trial is testing a procedure called Rezūm, which uses steam to shrink excess prostate tissue in men with benign prostatic hyperplasia (BPH), a common cause of urinary problems. About 50 men will receive the treatment, and researchers will track changes in urine flow, residua…
Sponsor: Can-Am HIFU Inc. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New hope for kidney disease: Zigakibart's Long-Term safety under study
Disease control Recruiting nowThis study looks at the long-term safety of a drug called zigakibart for adults with IgA nephropathy, a kidney disease. It is for people who have already finished a previous zigakibart study. Researchers will monitor side effects and check kidney function over 96 weeks.
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Scientists grow new urethras in lab to fix blockages
Disease control Recruiting nowThis early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…
Phase 1 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Could a 4-Week radiation course be as good as 5 weeks for prostate cancer?
Disease control Recruiting nowThis study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer …
Sponsor: CHU de Quebec-Universite Laval • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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New drug aims to calm immune attacks on kidneys
Disease control Recruiting nowThis Phase 2 study tests atacicept, a drug that may reduce immune system attacks on the kidneys. About 250 adults with various autoimmune kidney diseases (like IgA nephropathy or membranous nephropathy) will receive weekly injections. Researchers will check safety and measure cha…
Phase 2 • Sponsor: Vera Therapeutics, Inc. • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New drug BHV-1400 tested for kidney disease
Disease control Recruiting nowThis early-stage trial tests whether BHV-1400 is safe and tolerable for people with IgA nephropathy, a kidney disease. About 20 participants with confirmed IgA nephropathy will receive the drug subcutaneously. The main goal is to check for side effects and lab abnormalities.
Phase 1 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New adjustable implant aims to stop leakage in women
Disease control Recruiting nowThis trial tests a device called Adjustable Continence Therapy (ACT) for women with stress urinary incontinence caused by a weak urethral sphincter. The implant has two balloons placed near the bladder neck that can be adjusted after surgery to improve control. The study will enr…
Sponsor: Uromedica • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Spinal shock therapy: new device aims to restore bladder function in paralyzed veterans
Disease control Recruiting nowThis study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans and adults in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab…
Sponsor: University of British Columbia • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New hope for kidney cancer: Real-World study tests vorolanib as Second-Line therapy
Disease control Recruiting nowThis study looks at how well the drug vorolanib works for people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after their first one stopped working. The study will track how long the cancer stays under…
Sponsor: Jinling Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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No clamp, no stitch: new kidney surgery aims to save more function
Disease control Recruiting nowThis study tests a new surgical technique for removing small kidney tumors (up to 7 cm) using a robot. Instead of clamping the kidney's blood supply and stitching the wound closed, surgeons avoid clamping and use heat and special materials to stop bleeding. The goal is to preserv…
Sponsor: Shao Pengfei • Aim: Disease control
Last updated Jun 26, 2026 14:20 UTC
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New blood test aims to cut unnecessary prostate biopsies
Diagnosis Recruiting nowThis study is testing a new blood test called PROSTest to see if it can accurately detect prostate cancer in men with high PSA levels. Researchers will compare the test results with standard prostate biopsy findings in 1,500 men. If the test works well, it could help many men avo…
Sponsor: Wren Laboratories LLC • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC
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Can an AI agent match expert urologists? a major test begins
Diagnosis Recruiting nowUrological diseases like kidney stones, prostate cancer, and bladder cancer are common but require expert diagnosis. This study will develop and test an AI assistant called UroAgent that helps doctors make decisions by analyzing patient records and images. Researchers will use 2,…
Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Diagnosis
Last updated Jul 25, 2026 00:00 UTC
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Bladder monitor could replace awkward clinic tests
Diagnosis Recruiting nowThis study tests a new device called the Glean Urodynamics System, which uses sensors and an app to monitor bladder function both in the clinic and at home. It includes 101 adults with bladder issues like overactive bladder or incontinence. The goal is to see if the device is saf…
Sponsor: Bright Uro • Aim: Diagnosis
Last updated Jun 27, 2026 12:07 UTC
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Botox shot into bladder during prostate surgery may ease urgent bathroom trips
Symptom relief Recruiting nowThis study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or…
Phase 2/3 • Sponsor: Northwestern University • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Spa treatment shows promise for chronic kidney and urinary conditions
Symptom relief Recruiting nowThis study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…
Sponsor: Institute of Spa and Balneology, public research institution • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Let it fall? study tests if letting catheters drop out on their own is better than nurse removal
Symptom relief Recruiting nowThis study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Virtual reality headsets tested to ease pain and fear in urology patients
Symptom relief Recruiting nowThis study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people undergoing common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults having these procedures for the first time will use the VR device during…
Sponsor: Istituto Oncologico Veneto IRCCS • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Massive device registry aims to improve patient safety
Knowledge-focused Recruiting nowThis study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…
Sponsor: Medtronic • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Can surgery save the kidneys in deep endometriosis?
Knowledge-focused Recruiting nowThis study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…
Sponsor: Charles University, Czech Republic • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Brain scans reveal bladder control secrets in kids
Knowledge-focused Recruiting nowThis study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…
Sponsor: Aalborg University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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Tiny bugs may explain why some kids wet their pants
Knowledge-focused Recruiting nowThis study looks at the bacteria found in urine, the genital area, and stool of children with overactive bladder and daytime wetting, comparing them to healthy children. Researchers want to see if these bacteria differ between the groups and if they change with treatment or as ki…
Sponsor: Aalborg University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Blood in urine study aims to improve emergency care
Knowledge-focused Recruiting nowThis study watches how hospitals handle patients admitted with blood in their urine (hematuria). It will track things like how long people stay in the hospital and how quickly they get a diagnosis. The goal is to find the best ways to manage this condition and create guidelines f…
Sponsor: British Urology Researchers in Surgical Training • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Can videos and quizzes help patients better understand surgery?
Knowledge-focused Recruiting nowThis study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Can AI match doctors? new study puts ChatGPT to the test on urology cases
Knowledge-focused Recruiting nowThis study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…
Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can a smart monitor get you home faster after surgery?
Knowledge-focused Recruiting nowThis study tests whether using a device to continuously monitor heart rate, oxygen, and blood pressure after surgery — both in the hospital and at home — helps patients spend more days at home in the first month. About 110 adults having major abdominal or vascular surgery will be…
Sponsor: University of British Columbia • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Can MRI predict finasteride failure? new study seeks answers
Knowledge-focused Recruiting nowThis study aims to understand why some men with an enlarged prostate (BPH) do not respond to the common drug finasteride. Researchers will follow 120 men starting finasteride, tracking their symptoms and using MRI scans and genetic tests over three years. The goal is to find ways…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC