Urethral obstruction

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This study tests a special balloon coated with the drug paclitaxel, called Optilume, used to open narrowed areas in the urethra. Researchers want to see if it affects semen quality in men aged 22 to 65. The trial will measure changes in sperm concentration over 3 to 6 months in 3…

This study tests whether injecting a patient's own fat-derived cells during standard surgery can safely improve outcomes for urethral narrowing (stenosis). About 20 men aged 18-85 with bulbar stenosis ≤3 cm and at least one prior procedure will receive either standard surgery alo…

This study tests whether a special balloon coated with the drug paclitaxel (Optilume) can prevent urethral strictures from returning better than a standard balloon. About 230 adults with a recurrent stricture after at least one prior treatment will be randomly assigned to one of …

This study tests a step-by-step treatment plan for fetuses with lower urinary tract obstruction (LUTO), a condition where a blockage prevents urine from leaving the bladder. Doctors will use either a shunt to drain urine or a tiny scope to clear the blockage. The goal is to see i…

This study compares two surgical techniques for treating a narrowed urethra in women: using a graft from the mouth or from the labia. Forty women with non-traumatic urethral stricture will be randomly assigned to one of the two procedures. The main goal is to see which graft lead…

This study is testing a new, non-invasive urine flow test called the Urethral Resistive Index (URI) to diagnose urethral stricture in men. Currently, diagnosis often requires invasive procedures like surgery. The study will involve 60 men (30 with suspected stricture and 30 healt…