Urethral disorder

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This phase II trial is testing whether a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—can shrink or slow the growth of rare genitourinary cancers that have spread. About 314 adults with these uncommon tumors will receive the drugs. The goal is to see if the …

This large trial is testing whether a blood test that looks for tumor DNA can help decide who needs immunotherapy after surgery for muscle-invasive urothelial cancer. About 992 participants will be assigned to different treatment plans based on their blood test results. The goal …

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This trial tests a device called Adjustable Continence Therapy (ACT) for women with stress urinary incontinence caused by a weak urethral sphincter. The implant has two balloons placed near the bladder neck that can be adjusted after surgery to improve control. The study will enr…

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests a special balloon coated with the drug paclitaxel, called Optilume, used to open narrowed areas in the urethra. Researchers want to see if it affects semen quality in men aged 22 to 65. The trial will measure changes in sperm concentration over 3 to 6 months in 3…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This early-phase trial tests whether a patient's own immune cells, engineered to target BCMA and/or CD19, can calm severe ulcerative colitis that hasn't responded to other treatments. Twelve adults with moderate-to-severe active disease will receive a single infusion of these CAR…

This study tests whether injecting a patient's own fat-derived cells during standard surgery can safely improve outcomes for urethral narrowing (stenosis). About 20 men aged 18-85 with bulbar stenosis ≤3 cm and at least one prior procedure will receive either standard surgery alo…

This study tests whether a special balloon coated with the drug paclitaxel (Optilume) can prevent urethral strictures from returning better than a standard balloon. About 230 adults with a recurrent stricture after at least one prior treatment will be randomly assigned to one of …

This study tests a step-by-step treatment plan for fetuses with lower urinary tract obstruction (LUTO), a condition where a blockage prevents urine from leaving the bladder. Doctors will use either a shunt to drain urine or a tiny scope to clear the blockage. The goal is to see i…

This study compares two surgical techniques for treating a narrowed urethra in women: using a graft from the mouth or from the labia. Forty women with non-traumatic urethral stricture will be randomly assigned to one of the two procedures. The main goal is to see which graft lead…

This study is testing a new, non-invasive urine flow test called the Urethral Resistive Index (URI) to diagnose urethral stricture in men. Currently, diagnosis often requires invasive procedures like surgery. The study will involve 60 men (30 with suspected stricture and 30 healt…

This phase I/II trial tests a radioactive tracer called 64Cu-GRIP B, which targets granzyme B—a substance released by immune cells. By using PET scans, researchers hope to see immune activity in tumors and predict whether immunotherapy will work. The study involves about 91 adult…

This study looks at three different numbing methods to reduce pain in the mouth after a type of urethral surgery called buccal graft urethroplasty. Sixty men will be randomly assigned to one of the methods, and their pain levels and need for painkillers will be tracked. The goal …

This early study tests whether injecting a patient's own muscle fibers into the bladder neck or urethra is safe for treating urinary incontinence. Ten adult women with incontinence due to a weak outlet will be monitored for side effects and changes in leakage over 12 months.

This study tests a special laser treatment for women with long-lasting urethral pain that hasn't improved with other treatments. The laser is applied inside the urethra and vagina to try to reduce pain. The goal is to see if at least half of the 30 participants get significant pa…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study compares two X-ray settings during a procedure to treat overactive bladder. The goal is to see if a new setting reduces radiation exposure while still placing the device correctly. About 44 adults with overactive bladder will take part. The results could make this comm…

This study looks at whether a 3-day trial of a nerve-stimulating device for bladder control works as well as the standard 7-day trial. About 193 women with urgent or frequent urination will be randomly assigned to either a 3-day or 7-day test. The goal is to see if the shorter tr…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…