Transplant rejection

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This early-stage trial tests whether a single infusion of stem cells from donated fat tissue can safely treat rejection in kidney transplant recipients. The cells are delivered directly into the kidney artery. The study includes 12 adults with biopsy-proven rejection and aims to …

This study tested whether adding the drug rituximab to standard care could stop acute rejection in kidney transplant patients. 40 adults who had a kidney transplant within the past year and showed signs of acute humoral rejection took part. The main goal was to see if rituximab c…

This study looked at whether a 24-week exercise program can improve physical fitness, muscle strength, and overall health in people who received a kidney transplant. 345 adults joined the study six months after their transplant. Researchers compared those who exercised with those…

This study tested whether monitoring a substance in urine called CXCL10 can help detect kidney transplant rejection earlier. 260 adult kidney transplant patients were randomly assigned to either have their CXCL10 levels checked or receive standard care. If CXCL10 was high, patien…

This study tested two different drug combinations (Simulect or ATG, plus standard medications) in 60 kidney transplant patients at high risk of rejection. The goal was to see which approach better prevents treatment failure, including rejection, graft loss, or death, within 6 mon…

This study tested a new drug called CFZ533 in 418 kidney transplant patients to see if it could prevent organ rejection as well as the standard drug tacrolimus. Patients received either CFZ533 or tacrolimus along with other standard medications. The main goal was to compare rates…

This study tested the drug alirocumab in 114 heart transplant recipients to see if it safely reduces plaque buildup in the new heart's arteries. The drug targets a protein called PCSK9 to lower harmful cholesterol. Researchers measured changes in artery plaque using ultrasound at…

This study tests whether giving donor stem cells and a drug called Campath-1H can help kidney transplant recipients stop taking anti-rejection medications permanently. Eighty-eight patients receiving a kidney from an identical sibling will get the stem cell infusions and temporar…

This study tested whether a drug called bortezomib, given with steroids, plasma exchange, and immunoglobulins, can treat chronic antibody-mediated rejection in kidney transplant recipients. The trial included 60 adults who had a kidney transplant and developed donor-specific anti…

This Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care can improve lung function in 169 double lung transplant patients with chronic rejection. Participants inhaled the drug twice daily for 48 weeks. The main goal was to see if it slowed the de…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tested a phone-based coaching program to help teenagers who had a liver transplant take their anti-rejection medication regularly. The program used personalized calls to improve adherence, with the goal of reducing organ rejection. A total of 148 teens aged 12 to 20 wh…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could prevent the body from rejecting the kidney as well as or better than current standard treatments. Participants received different combinations of drugs, and r…

This Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care helps single lung transplant patients with chronic lung rejection. 62 adults who had a single lung transplant at least a year earlier and had signs of chronic rejection took part. The study…

This study tested a new medicine called tegoprubart in 127 people who received a kidney transplant. The goal was to see if it works better than the standard drug tacrolimus at preventing the body from rejecting the new kidney. Participants took the study drug and were monitored f…

This study tested whether a once-daily version of the anti-rejection drug tacrolimus (Envarsus) works as well as the standard twice-daily version (Prograf) in heart transplant recipients. Fifty adults who had a heart-only transplant were enrolled. The goal was to see if the easie…

This study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …

This study tested whether adding the drug bortezomib to a standard treatment (rituximab, plasma exchange, and IVIG) helps control antibody-mediated rejection in kidney transplant patients. Twenty participants were enrolled, and researchers measured kidney function and rejection m…

This study tested whether analyzing proteins from kidney biopsy and urine samples can improve the diagnosis of microvascular inflammation, a key sign of antibody-mediated rejection in kidney transplant recipients. Researchers used mass spectrometry to find protein signatures in 1…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study looked at whether a simple blood test measuring tiny molecules called microRNAs can spot rejection in heart transplant patients. Researchers tested 461 patients and compared the blood test results with standard heart biopsies. If the blood test works well, it could off…

This study aims to find substances in blood or urine that can signal when a transplanted heart is being rejected. By analyzing samples from 188 heart transplant patients and healthy volunteers, researchers hope to develop a simple test for early detection. The goal is to catch re…

This completed study looked at 116 kidney transplant patients to understand how B cells (a type of immune cell) behave in those who develop donor-specific antibodies or chronic rejection. Researchers analyzed blood samples to find patterns that could serve as early warning signs.…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether proteins in ostomy fluid (waste from the intestine) can signal rejection after an intestinal transplant. Currently, doctors must take tissue samples through a scope to check for rejection, which is invasive and not always accurate. Researchers analyze…

This study looked at whether shared genetic markers (HLA) between a child and a lung donor increase the risk of organ rejection in mothers who had a lung transplant. Researchers collected DNA from children born to 11 transplant women in France between 2012 and 2021. The goal is t…

This study followed 60 heart transplant patients for one year to see if levels of a harmless virus called TTV in the blood are linked to infections or organ rejection. Researchers took monthly blood samples alongside routine care. The goal is to find a new way to monitor transpla…

This study tested new MRI and MRE techniques that let children breathe normally during scans, instead of holding their breath. The goal was to measure liver fat and stiffness more comfortably and accurately in kids with fatty liver disease. 135 children aged 6-17 took part, and t…

This study looked at whether levels of a common virus called Torque teno virus (TTV) can help doctors monitor how well a kidney transplant patient's immune system is suppressed. The goal is to find a simple blood test that could predict rejection or infection. Researchers followe…

This study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…

This study examined whether a protein called CD160 appears in new blood and lymph vessels that grow in the cornea after a transplant. Researchers analyzed tissue from 43 patients who had corneal transplant surgery. The goal was to see if CD160 is linked to graft rejection, which …

This study tested whether a device that measures body composition (bioelectrical impedance spectroscopy) can help predict complications after a heart transplant. Researchers followed 69 adult heart transplant patients for one year, tracking changes in muscle and fat. The goal was…

This study looked at whether a molecular test called HistoMx can help doctors better diagnose kidney transplant rejection in everyday practice. Researchers followed 400 kidney transplant recipients to see how often the test was used and whether it improved patient outcomes. The g…

This study followed 600 lung transplant recipients at the University of Pittsburgh to see how common viral and bacterial infections are and how they affect long-term health. Researchers focused on whether a specific infection (C. pneumoniae) is linked to a condition called bronch…