Urine test may catch kidney rejection before it's too late
NCT ID NCT03206801
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether monitoring a substance in urine called CXCL10 can help detect kidney transplant rejection earlier. 260 adult kidney transplant patients were randomly assigned to either have their CXCL10 levels checked or receive standard care. If CXCL10 was high, patients got a biopsy to check for rejection. The goal was to see if early detection and treatment could improve kidney survival and function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
urine CXCL10 monitoring (a urine test to detect early signs of rejection)
What this could lead to
If successful, this approach could help doctors detect kidney transplant rejection earlier, potentially preventing long-term damage and improving graft survival.
What could go wrong
This is a mid-stage trial, so results may not be definitive. The test may not reliably predict rejection in all patients, and early treatment might not improve overall outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centre de recherche du CHUM (CRCHUM)
Montreal, Quebec, Canada
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McGill
Montreal, Quebec, Canada
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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University Health Network, University of Toronto
Toronto, Ontario, Canada
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University of Calgary
Calgary, Alberta, Canada
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University of Manitoba, Transplant Manitoba Adult Kidney Program
Winnipeg, Manitoba, R3A 1R9, Canada
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University of Ottawa
Ottawa, Ontario, Canada
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Université Laval
Québec, Quebec, Canada
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Western University
London, Ontario, Canada