Urine test may catch kidney rejection before it's too late

NCT ID NCT03206801

Completed Disease control Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether monitoring a substance in urine called CXCL10 can help detect kidney transplant rejection earlier. 260 adult kidney transplant patients were randomly assigned to either have their CXCL10 levels checked or receive standard care. If CXCL10 was high, patients got a biopsy to check for rejection. The goal was to see if early detection and treatment could improve kidney survival and function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: urine CXCL10 monitoring (a urine test to detect early signs of rejection)
What this could lead to: If successful, this approach could help doctors detect kidney transplant rejection earlier, potentially preventing long-term damage and improving graft survival.
What could go wrong: This is a mid-stage trial, so results may not be definitive. The test may not reliably predict rejection in all patients, and early treatment might not improve overall outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT; COMPLICATIONS REJECTION OF RENAL TRANSPLANT

Contacts and locations

Locations

Centre de recherche du CHUM (CRCHUM)

Montreal, Quebec, Canada
McGill

Montreal, Quebec, Canada
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
University Health Network, University of Toronto

Toronto, Ontario, Canada
University of Calgary

Calgary, Alberta, Canada
University of Manitoba, Transplant Manitoba Adult Kidney Program

Winnipeg, Manitoba, R3A 1R9, Canada
University of Ottawa

Ottawa, Ontario, Canada
Université Laval

Québec, Quebec, Canada
Western University

London, Ontario, Canada

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