Temporomandibular joint disorder

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…

This study tests whether a new Fast Fix suturing system works better than the usual method for repositioning the jaw joint disc in people with TMJ internal derangement. About 50 adults who need surgery after other treatments failed will be randomly assigned to one of the two tech…

This study will test a 4D virtual simulator called Modjaw to see if it helps doctors diagnose temporomandibular joint (TMJ) disorders more accurately. About 20 adults with suspected disc displacement will use the device, and the results will be compared to MRI scans. The goal is …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study looks at whether adding a special relaxation training (EMG-biofeedback) to a standard exercise program can help people with jaw joint pain (TMJ disorder). The training helps people become more aware of their muscle tension so they can relax better. Forty adults with TM…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study will test whether a hard dental splint or a simpler approach (ibuprofen gel plus counseling) works better for jaw joint pain. About 60 adults with TMJ disorders will be randomly assigned to one of the two treatments. Pain levels will be measured after 1 week and 4 week…

This study compares two non-drug treatments—ultrasound and virtual reality—for reducing pain and improving jaw movement in people with temporomandibular disorder (TMD) after tooth extraction. Fifty adults aged 40-60 with pain and limited mouth opening will be enrolled. The goal i…

This study tests whether adding dual-task exercises (combining physical movements with mental tasks) to standard physiotherapy, delivered via telerehabilitation, can reduce pain and improve jaw function in young adults with temporomandibular joint (TMJ) dysfunction. Thirty partic…

This study tests two methods of injecting platelet-rich fibrin (PRF) into the jaw joint for people with a displaced disc that causes pain and limited mouth opening. One method uses ultrasound to guide the needle, the other uses a tiny camera (arthroscope). The goal is to see whic…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This pilot study will test whether a non-invasive vagus nerve stimulation (nVNS) device can reduce jaw pain and improve mood in 10 premenopausal women with temporomandibular disorders (TMD). Participants will receive the treatment twice a week for 8 weeks and undergo brain scans,…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study tests whether a mix of two drugs (triamcinolone and lidocaine) injected into jaw muscle trigger points can reduce pain in people with TMJ disorders. About 30 adults will receive either the active injection or a placebo. The main goal is to see if it lowers pain intensi…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two methods of injecting medicine into the jaw joint to relieve pain and improve function: one using a tiny camera (arthroscopy) and the other using ultrasound guidance. About 50 adults with long-term jaw pain will take part. The goal is to see which approach …

This study looks at whether adding stress management and sleep education to standard physiotherapy can help people with temporomandibular disorders (TMD). TMD causes jaw pain, teeth grinding, and sleep problems. Forty adults with TMD will receive either physiotherapy alone or phy…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests whether adding core-strengthening exercises to standard physical therapy can reduce pain and improve function in people with temporomandibular joint (TMJ) disorders. Fifty adults with jaw pain will be randomly assigned to either standard TMJ therapy or standard t…

This study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…

This study looks at how aerobic exercise influences pain processing in people with chronic jaw pain (TMD). Researchers will compare pain responses among three groups: patients with jaw pain, inactive healthy people, and healthy endurance athletes. The goal is to understand if exe…

This study looks at 700 adults who had jaw joint (TMJ) surgery and received either platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injections during the operation. Researchers will review medical records to see which group had less pain and better jaw function six months…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This study investigates the connection between temporomandibular joint (TMJ) disorders and tinnitus (ringing in the ears). Researchers will use 3D jaw imaging and hearing tests in 50 adults to see if jaw bone shape and arthritis are linked to tinnitus. The goal is to better under…

This study aims to see if an Arabic translation of a short 8-question survey about jaw function is accurate and reliable for people with jaw joint disorders. Researchers will ask 100 Arabic-speaking adults with jaw pain or limited movement to complete the survey. The goal is to p…

This study looks at how a common jaw joint problem (TMJ disc displacement) might be connected to changes in the neck bones. Researchers will use X-rays and MRIs to measure the shape and posture of the upper neck vertebrae in 115 people with TMJ issues. The goal is to better under…

This study aims to translate the Helkimo Clinical Dysfunction Index, a tool used to assess jaw joint problems, into Turkish and check if it is reliable and accurate. Researchers will test it on 48 Turkish-speaking adults with temporomandibular disorder (TMD) by comparing it with …

This observational study will measure how well the upper neck moves and how that relates to jaw motion in 50 adults with temporomandibular disorders (TMD). Participants will have their neck and jaw movements measured with simple tools. The goal is to understand if limited neck mo…

This study will look at tissue and bacteria samples from 20 people having surgery for severe temporomandibular joint (TMJ) problems like ankylosis or osteoarthritis. Researchers want to find out what causes these severe conditions and whether bacteria in the joint affect recovery…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at how the position of your head affects the movement of your jaw joints (TMJ) in people aged 11 to 65 who are getting braces or dental reconstruction. Researchers will measure jaw and neck movement before and after a brief hands-on therapy session to see if it h…

This study will use fMRI brain scans to see if long-term jaw pain (TMJ disorder) causes changes in the brain. Researchers will compare brain activity in 60 patients with chronic TMJ pain. The goal is to understand how pain and related anxiety or depression might alter brain struc…

This study compares how well people with chronic jaw pain (TMD) and healthy volunteers can detect thin foils placed between their teeth. Researchers will test 80 participants to see if TMD reduces bite sensitivity. The goal is to better understand how jaw pain affects daily funct…