Staphylococcal infection

This early-stage study tested a new vaccine called LTB-SA7 designed to protect against infections caused by Staphylococcus aureus bacteria. 129 healthy adults received either the vaccine or a placebo to check for safety and to see if the vaccine triggers an immune response. The s…

This trial examines whether using a quick nasal swab to check for MRSA bacteria can help doctors decide how long to treat pneumonia patients with the antibiotic vancomycin. The study compares the duration of therapy and costs before and after implementing this screening test. Par…

This pilot study compares a new decolonization regimen using polyhexanide (nasal gel and body foam) to the standard mupirocin and chlorhexidine treatment for reducing Staphylococcus aureus bacteria before elective spine surgery. The trial includes 24 adults who carry Staph bacter…

This study tested whether a combination of topical antibiotics and antiseptic washes could reduce staph bacteria on the skin of Native American adults living on or near tribal lands. Participants were at high risk for staph infections due to diabetes, obesity, or recent infection…

This completed trial tested a centralized care model for patients with serious staph bloodstream infections. Over 2,500 adults in Alberta hospitals received automated alerts and expert recommendations to ensure they got the right tests, antibiotics, and specialist care. The goal …

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested a checklist to prevent MRSA surgical site infections in over 23,000 veterans undergoing joint replacement or heart surgery. The checklist included using antibiotic ointment and antiseptic baths before surgery, plus antibiotics during surgery. Researchers measure…

This study tested whether an early, computer-guided dosing strategy for vancomycin helps children with MRSA infections reach the right drug levels faster than the usual approach. 100 children aged 1 month to 16 years took part. The goal was to improve treatment effectiveness whil…

This study tested a new medicine called AP-SA02, given through a vein, along with standard antibiotics for adults with a Staph blood infection. The main goal was to check if the combination is safe and tolerable. Researchers also looked at whether it helped clear the infection fa…

This study tested a rapid blood test (T2Bacteria Panel) that identifies bacteria directly from blood, compared to standard blood cultures that take 1-3 days. Researchers wanted to see if using this test could help doctors stop unnecessary vancomycin (a strong antibiotic) sooner i…

This study tested a lab-made antibody called 514G3 in 52 hospitalized adults with Staphylococcus aureus bloodstream infections. Participants received either a single dose of the antibody plus standard antibiotics or a placebo plus antibiotics. The main goals were to check safety …

This study compared two common antibiotics, doxycycline and TMP-SMX, for treating uncomplicated skin infections like boils and cellulitis. 269 people aged 9 to 85 took one of the drugs for 7 days. Researchers checked if the infection cleared up early, at the end of treatment, and…

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or…

This study tested whether adding an oral antibiotic called clindamycin to the usual topical treatment (nasal ointment and special baths) helps clear MRSA bacteria from the throat. Fifty-three adults who still carried MRSA in their throat after standard treatment took either clind…

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

This completed trial tested a device that uses light to kill germs in the nose before surgery, aiming to prevent surgical site infections. Over 400 adults having major surgeries received either the light treatment or standard care. Researchers tracked infections and side effects …

This study tested a new way to prevent surgical site infections by using a special light treatment inside the nose just before surgery. Over 4,700 adults having major surgeries like heart, spine, or joint replacement took part. The goal was to see if this light therapy reduces in…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This study compared staph bacteria from 57 patients with implant infections to 31 from healthy nasal carriers. Researchers looked at the bacteria's genes and ability to form biofilms (slimy coatings). The goal was to find what makes some staph strains more dangerous around implan…

This study looked at a new lab test called Antibiofilmogramme for people with diabetic foot infections caused by Staph bacteria. The goal was to see if the test could help doctors choose antibiotics that work better. 33 adults took part, and the study did not change their regular…

This study looked at two different ways of giving the antibiotic cloxacillin to treat bone and joint infections caused by Staphylococcus aureus bacteria. Twelve patients received the drug both as a steady drip (continuous infusion) and as short doses (intermittent infusion) to se…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…

This study examined tissue samples from 50 patients with staphylococcal bone and joint infections to see if bacteria can hide inside human cells. Researchers used special staining to detect intracellular staphylococci and identify which cell types they occupy. The goal was to bet…

This lab study tested whether levobupivacaine, a local anesthetic used in patient-controlled analgesia (PCA) pumps, can kill Staphylococcus aureus bacteria. Researchers mixed the drug at two common concentrations with bacteria in a lab model and counted how many bacteria survived…

This study tested whether having a study team call doctors with a checklist could improve how they manage patients with Staphylococcus aureus bloodstream infections. The calls reminded doctors of key steps like follow-up blood cultures, proper antibiotics, and imaging tests. The …

This completed study tracked 581 hospitalized children aged 1-16 to see how antibiotic treatment affects the development of MRSA in the nose. Researchers compared children who received antibiotics to those who did not. The goal is to understand how antibiotic use drives antimicro…

This study looked at 278 diabetic patients to see if the same staph bacteria found in their noses also appear in their foot ulcers. Researchers compared the genetic fingerprints of the bacteria to understand the link. The goal was to learn more about infection risks, not to test …

This completed study tested a software platform called OR PathTrac that monitors bacteria in operating rooms. The goal was to see if giving hospitals feedback on where germs spread could help reduce surgical site infections. Over 800 adults having surgery took part. The study foc…

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …