Psoriasis

This study looks at 120 adults with moderate-to-severe psoriasis who take secukinumab, a biologic drug. It compares two maintenance schedules: the standard every-4-week injection versus a non-standard schedule (longer intervals or lower dose). The goal is to see which schedule ke…

This study will test whether a newer cream called tapinarof works better than the standard betamethasone cream for mild-to-moderate plaque psoriasis. About 120 adults will use one of the two creams daily for up to 12 weeks. The main goal is to see how many people get at least a 7…

This study compares two oral medications, methotrexate and tofacitinib, for treating chronic plaque psoriasis. About 88 adults with moderate to severe psoriasis who haven't improved with topical treatments will be randomly assigned to one of the drugs and followed for six months.…

This study tests two oral medications—roflumilast and methotrexate—for psoriasis in skin folds and genital areas, which are often hard to treat with creams alone. Fifty-six adults with topical-resistant psoriasis will take one of the two pills for 16 weeks. Researchers will measu…

This phase 3 trial tests whether RSS0393 ointment can improve plaque psoriasis compared to a placebo. About 600 adults with mild-to-moderate psoriasis will apply the ointment daily for 8 weeks. The main goal is to see if more people achieve clear or almost-clear skin with RSS0393…

This study tests the drug adalimumab in 30 Chinese children aged 4 to 17 with severe plaque psoriasis that hasn't improved with creams or light therapy. The goal is to see if adalimumab can safely reduce skin symptoms like redness and scaling. The main measure is how many childre…

This Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This study tests a new cream made with tiny nanoparticles of the drug apremilast for people with mild to moderate plaque psoriasis. Thirty-six adults will apply the cream twice daily for 12 weeks, and researchers will compare it to a standard steroid cream and a combination of bo…

This study tests an experimental tablet called CMS-D001 for adults with moderate to severe plaque psoriasis. About 540 participants will receive either the drug or a placebo to see if it improves skin symptoms like redness, scaling, and thickness. The goal is to measure how many …

This phase 4 trial tests whether adding recaticimab to vunakizumab works better than vunakizumab alone for adults with moderate-to-severe plaque psoriasis and high cholesterol. Forty participants will be randomly assigned to receive either the drug combo or vunakizumab plus a pla…

This phase 4 trial will test the drug apremilast in 425 adults with moderate-to-severe psoriasis. Over 32 weeks, researchers will measure how well the drug clears skin patches and monitor for side effects. The goal is to confirm apremilast's effectiveness and safety in a real-wor…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This phase 2 trial tests an oral tablet called HSK47388 in 220 adults with moderate-to-severe plaque psoriasis. Participants take the drug or a placebo once daily for 16 weeks. The main goal is to see if the drug can reduce psoriasis severity by at least 75% compared to placebo.

This phase 2 trial tests an oral drug called HSK44459 for adults with moderate to severe plaque psoriasis. About 150 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug can reduce psoriasis skin symptoms by at least 75%.

This study will test a special ultrasound technique called shear-wave elastography to see if it can better detect tendon inflammation (enthesitis) in people with psoriatic arthritis. Researchers will compare this method with standard ultrasound and also look at how it relates to …

This study tests whether adding a pill called pentoxifylline to standard skin creams can improve mild-to-moderate psoriasis. About 140 adults will take either the study drug or a placebo twice daily for 12 weeks. Researchers will measure changes in skin severity, itch, and qualit…

This study will test whether methotrexate or apremilast works better at reducing itching and improving daily life in 80 adults with psoriasis. Participants will take one of the two oral medications for 8 weeks. The main goal is to see which drug provides more relief from the itch…

This study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…

This study tests a cream called PROXERA PSOMED 30, which contains 30% urea, for treating nail psoriasis. 21 adults with nail psoriasis will apply the cream to one nail and Vaseline to another nail twice daily for 24 weeks. Researchers will compare how much each nail improves usin…

This study tests whether a cream made from metformin, a common diabetes drug, can safely improve mild psoriasis. About 55 adults will apply either the metformin cream or a placebo twice daily for two months. Researchers will check skin biopsies and symptom scores to see if the tr…

This Phase 2 trial tests a daily nail lacquer containing 2% tofacitinib for nail psoriasis. Ten adults with nail psoriasis will apply the lacquer at home for 26 weeks. Researchers will measure changes in nail appearance using the Nail Psoriasis Severity Index and quality of life …

This study tests whether a single 23-30 minute session of specially designed music or pink noise can reduce anxiety in adults with psoriasis. About 120 participants will listen at home using headphones. The goal is to see if audio therapy offers a quick, accessible way to manage …

This study looks at whether losing weight can make psoriasis treatments more effective in overweight or obese patients. About 70 adults with moderate-to-severe plaque psoriasis will either get standard care alone or standard care plus a personalized weight loss plan (diet, exerci…

This study tests if a cream made from diacerein can safely reduce psoriasis symptoms like redness and scaling. About 60 adults with mild psoriasis will apply the cream or a placebo twice a day for two months. Doctors will check their skin at several visits to see if the cream lea…

This study tests whether letting patients report their symptoms online can help doctors schedule follow-up visits only when needed. About 250 adults with chronic skin conditions like eczema or psoriasis will either get standard fixed appointments or flexible scheduling based on m…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …

This study looks at whether changing how much salt you eat can affect skin sodium levels and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either sodium tablets or a placebo for several weeks. The goal is to see if this approach is practic…

This study tests a tiny microdevice, about the size of a grain of rice, that holds up to 20 different FDA-approved skin medications. Placed directly on the skin, it releases very small amounts of each drug to see how the skin reacts. The goal is to find out if this device can saf…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study explores whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults will be split into three groups: weekly AI videos, weekly human doctor videos, or standard care (one follow-up vis…

This study looks at whether the placement of hand sanitizer in a doctor's office affects how much psoriasis patients trust their doctor and feel stigmatized. Researchers will observe doctors' hand hygiene habits and ask 250 patients to fill out questionnaires. The goal is to find…

This study looks at how two common psoriasis drugs, cyclosporine and methotrexate, affect a protein called IL-33 in the blood. Researchers will measure IL-33 levels and track psoriasis severity in 118 adults with moderate to severe psoriasis. The goal is to understand how these d…

This study is testing a new, non-invasive way to collect and analyze skin oil (sebum) using a simple adhesive patch called Sebutape. Researchers will recruit 200 people, including healthy volunteers and patients with acne, eczema, psoriasis, or seborrheic dermatitis. The goal is …

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This study will review medical records of 300 children under 18 with psoriasis in Costa Rica. Researchers want to learn about the children's symptoms, how severe the disease is, what other health problems they have, and what treatments they receive. No new treatments or tests are…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness in psoriasis lesions. Fifty adults with psoriasis will take weekly photos at home and have clinic photos taken. The goal is to see if this simple, low-cost method mat…

This observational study will follow 45 adults with severe plaque psoriasis to see how standard treatment affects their skin, dermoscopic images, and quality of life. Participants will be evaluated at the start and again after 12 and 24 weeks of treatment. The goal is to better u…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study creates a national registry for people with generalized pustular psoriasis (GPP) in Costa Rica. Researchers will collect information from about 50 patients to better understand the disease, how it progresses, and what treatments are used. The goal is to improve care fo…

This study will take high-resolution photos of the eyes of 950 people with psoriasis, eczema, or hives, plus healthy volunteers. Using artificial intelligence, researchers aim to find eye patterns linked to these skin conditions. The goal is to create a noninvasive tool for earli…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at whether tongue and facial images can help doctors understand psoriasis better. Researchers will collect photos and lab data from 450 people with and without psoriasis. The goal is to find patterns that link Traditional Chinese Medicine signs to blood tests and…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study will examine 60 adults with psoriasis to understand why they often have higher rates of gum disease. Researchers will measure immune-related proteins and stress hormones in saliva and gum fluid, and also ask about appearance-related anxiety. The goal is to uncover biol…