Pustular psoriasis

This study tests a cream called delgocitinib for people with mild to severe palmoplantar pustulosis, a skin condition causing painful pus-filled blisters on hands and feet. About 135 adults will apply the cream twice daily for 16 weeks. The main goal is to see if the cream reduce…

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…

This study tests a drug called picankibart in 60 adults with moderate-to-severe palmoplantar pustulosis, a painful skin condition causing pus-filled blisters on hands and feet. Participants receive injections of picankibart over nearly a year. The goal is to see if it reduces the…

This study tests a new biologic drug called Xeligekimab in 10 adults with moderate to severe palmoplantar pustulosis (PPP), a chronic skin disease causing painful blisters and scales on the palms and soles. The goal is to see if the drug can reduce symptoms and improve quality of…

This study tests a daily pill called ivarmacitinib for palmoplantar pustulosis (PPP), a chronic skin condition causing painful blisters on hands and feet. Sixty adults who haven't improved with other treatments will take the pill for 12 weeks. Researchers will check if symptoms l…

This study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…

This study collects skin samples from 500 people with conditions like acne, eczema, and psoriasis, as well as healthy volunteers. Researchers will analyze the samples to find biomarkers and gene patterns linked to inflammation. The goal is to better understand these skin diseases…

This study is a registry that will follow about 200 people with generalized pustular psoriasis (GPP) across North America. Researchers want to learn more about how GPP develops, how it is managed, and what happens to patients over time. Participants will be under the care of a de…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…