Inherited lipid metabolism disorder

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study tests whether adding ear acupressure (small pellets on specific ear points) to the standard cholesterol drug atorvastatin can lower blood fats and improve phlegm-dampness symptoms better than a sham ear treatment plus atorvastatin. Eighty adults with dyslipidemia and p…

Researchers are testing a new oral drug called AZD0780 in healthy adults, some with high LDL cholesterol. The Phase 1 trial gives single and multiple rising doses to check safety, side effects, and how the body processes the drug. About 183 volunteers will take either AZD0780 or …

This trial tests an experimental medicine called NNC0491-6075 for people with high levels of fat in the blood. The main goal is to check whether the medicine is safe and how the body handles it. Healthy volunteers receive a single dose, while people with high blood fat receive we…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This study looks at whether taking two approved medicines together—escitalopram for depression and atorvastatin for high cholesterol—can improve both mood and blood fat levels in adults. Participants are adults diagnosed with both a depressive episode and mild-to-moderate dyslipi…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This early-stage trial tests two experimental drugs, UI111 and UIC202006, in healthy adult volunteers. The goal is to check the drugs' safety and how the body processes them after a single dose taken with food. The study uses a crossover design, meaning each participant receives …

This trial investigates whether a digital health app called Lipodia can help lower LDL (bad) cholesterol in adults with high cholesterol. Participants either use the app alongside their usual treatment or continue with usual treatment alone. The study measures cholesterol levels …

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested a dietary supplement made from olive and myrtle extracts in 112 adults with mildly high cholesterol. Participants took either the supplement or a placebo daily for three months while following a controlled diet. The goal was to see if the supplement could help m…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This study tested whether taking vitamin E (400 mg daily) alone or together with psyllium husk (10 g daily) for 60 days could improve blood fat levels in adults with high cholesterol and triglycerides. Sixty participants aged 40–60 were randomly assigned to one of three groups: v…

This study looked at the long-term safety of a drug called ARO-APOC3 in adults with dyslipidemia (abnormal fat levels in the blood). Participants who completed a previous 12-month study could continue receiving the drug every 3 or 6 months. The goal was to see if the drug remains…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at whether eating different amounts of pecans every day for 28 days can improve cholesterol and other heart health markers in adults who are overweight or have high cholesterol. 108 participants were split into groups that ate pecans providing 6%, 13%, or 20% of…

This study looked at whether adding small amounts of cottonseed oil to the diet can improve cholesterol and other heart disease risk factors. 95 adults at increased risk for heart disease drank shakes and ate snacks with different amounts of cottonseed oil for 28 days. Researcher…

This study tested whether a special extract from plants (phytosterols and phytostanols) can help lower cholesterol levels in adults with high cholesterol. 42 people took either the extract or a placebo for a period of time. The main goal was to see if the extract could reduce tot…

This completed Phase 4 trial tested a single pill containing three medicines (telmisartan, amlodipine, and rosuvastatin) in 252 Korean adults with both high blood pressure and high cholesterol. Participants took either the triple pill or a two-drug pill for 8 weeks. The study mea…

This study tested a low dose (10 mg) of the statin drug rosuvastatin in 242 Korean adults with high cholesterol or heart disease risk. The goal was to see how much it lowered 'bad' LDL cholesterol after 8 weeks. Results help guide cholesterol treatment in this population.

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults with established cardiovascular disease participated. The program used smartphone tools to improve treatment and follow gu…

This study tested whether drinking unsweetened soymilk every day can lower cholesterol in adults with high levels. Twenty-five participants drank two bottles (750 mL total) daily for 8 weeks. Researchers measured cholesterol and other health markers to see if the soymilk helped i…

This completed Phase 4 trial tested the drug atorvastatin (Lipitor) in 100 children aged 8-18 with steroid-sensitive nephrotic syndrome and high cholesterol. The goal was to see if the drug safely lowers cholesterol to healthy levels within 3 to 6 months. The study compared atorv…

This study tested whether a daily dietary supplement could lower LDL (bad) cholesterol in 90 healthy adults with slightly high levels. Participants took either the supplement or a placebo for 12 weeks, along with standard diet advice. The main goal was to see if the supplement re…

This early-stage study tested an experimental drug called ALN-APOC3 in 32 adults with dyslipidemia (abnormal blood fat levels). The main goal was to check safety and how the drug affects fat levels in the blood. Participants were otherwise healthy and either not on statins or on …

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This completed early-phase trial tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could improve cholesterol and reduce early signs of artery hardening compared to staying on integrase inhibitors. Twenty-six adults with well-con…

This study looked at whether adding elastic band resistance training to waltz dancing could help improve cholesterol levels in women aged 45 to 65 with dyslipidemia (abnormal blood fats). Sixty women participated in a 12-week program of supervised exercise classes three times a w…

This study tested a drug called Cipros 20 in 406 adults with dyslipidemia (abnormal levels of fats in the blood) who also had high or very high heart disease risk. The goal was to see if it lowers triglycerides and LDL cholesterol more effectively than current options. Participan…

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether a Mediterranean diet that removes red and processed meat can lower LDL cholesterol and other heart disease risk factors. 157 adults with high cholesterol were assigned to either the special diet or standard heart-health advice for 8 weeks. Researchers me…

This early-stage study tested a new medicine called ARO-ANG3 in 93 people, including healthy volunteers and patients with high cholesterol or high triglycerides. The main goal was to check if the drug is safe and how the body processes it. This research helps determine if the dru…

This early-stage study tested the safety of Atorvo+™, a new drug that combines the common cholesterol-lowering medication atorvastatin with cannabidiol (CBD). The trial involved 24 healthy adults aged 40-75 to see how the body processes the drug and if it causes any side effects.…

This study tested whether a daily combination of commercially available food supplements could help overweight adults over 45 feel fuller and improve their cholesterol and blood sugar levels. Eighty participants were split into two groups: one took the supplement mix for 12 weeks…

This Phase 3 trial tested a new combination drug called Cipros 10 against the standard statin Crestor in 146 adults with dyslipidemia (high cholesterol and triglycerides). The goal was to see if Cipros 10 could lower triglyceride levels more effectively. Participants took one pil…

This study tested a new extended-release form of pemafibrate (K-877) in 121 adults with high triglycerides, a type of fat in the blood. Participants took the drug once daily for 52 weeks, either in the morning or evening, to see if it safely lowers triglyceride levels and improve…

This study tested a new daily medication called AZD0780 in 428 adults with dyslipidemia (abnormal cholesterol levels). Participants took one of several doses of AZD0780 or a placebo for 12 weeks. The main goal was to see how much the drug lowered LDL (bad) cholesterol compared to…

This early-stage study tested a new drug called AZD0780 in 81 healthy adults with high cholesterol. Participants received AZD0780 alongside other cholesterol-lowering medicines like ezetimibe, rosuvastatin, or bempedoic acid. The goal was to see how well the combination lowers LD…

This study tested a 3-month lifestyle program, delivered by Pasifika community health workers, to help Native Hawaiians and Pacific Islanders with conditions like diabetes, high blood pressure, and obesity. The program included healthy eating and activity tips plus support for so…

This study tested a new controlled-release version of the drug pemafibrate in 60 adults with dyslipidemia (abnormal levels of fats in the blood). The goal was to see if the new version works as well or better than the current immediate-release tablet, with fewer side effects. Par…

This Phase 3 trial tested a daily pill combining two drugs, obicetrapib and ezetimibe, in 407 people with inherited high cholesterol or heart disease. Participants took the combination or a placebo on top of their usual cholesterol meds. The main goal was to see if the combo lowe…

This study tested a new drug called obicetrapib in over 2,500 people with high cholesterol that wasn't well controlled by their current treatments. Participants took either a 10 mg obicetrapib pill or a placebo daily for about 6 months. The main goal was to see if obicetrapib cou…

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This early-phase study tested a single dose of VSA003 in 36 healthy Chinese adults to see if it is safe and how the body handles it. The drug aims to help control high cholesterol and triglycerides. Participants received either VSA003 or a placebo, and researchers monitored for s…

This completed Phase 3 trial tested a combination of two drugs, JW0108 and C2407, in 145 adults with high cholesterol (dyslipidemia). The goal was to see if the combo lowers LDL ('bad') cholesterol more effectively and safely than placebo. Researchers measured changes in LDL leve…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

Researchers are studying how traditional and non-traditional heart risk factors relate to cholesterol levels in hospitalized Mexican adults. The study focuses on HDL cholesterol, often called good cholesterol, and how it behaves in people who smoke or have certain dietary habits.…

This study checks if a new version of a cholesterol-lowering drug (AJU-C715) works the same as the original (C715R) in 60 healthy adults aged 19-59. Participants take a single dose of each drug in random order and have blood tests to compare drug levels. The goal is to see if the…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is …

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study will assess the diet, heart health, body composition, mental wellbeing, and physical performance of 600 U.S. Army soldiers. Researchers aim to gather detailed data on nutrition and health, similar to a national survey but tailored for the military. The goal is to bette…

This early-stage trial tests a new drug called AJU-C716 against a reference drug (C716R) in 41 healthy adults aged 19 to 55. The goal is to see how safe the drug is and how the body processes it. This study does not test if the drug works for high cholesterol—it only looks at saf…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at 99 people with high heart risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity, artery thickness, and calcium scores. The goal was to learn more about heart disease, not to test a new treatment.

This early-stage study tested a single injection of HRS-5632 in 50 healthy adults to check its safety and how the body processes it. Participants were aged 18 to 55 and in good health. The study did not aim to treat any disease, only to gather initial safety information.

This study looked at 86 people with very high or very low cholesterol efflux—a measure of how well the body removes cholesterol from cells. Researchers analyzed their genes, proteins, and lipids to find clues that could lead to new ways to prevent or reverse heart disease. The go…

This study looked at how taking statins (a common cholesterol-lowering drug) along with a structured exercise program affects muscle cells and overall fitness in adults aged 40-65 with high cholesterol. 120 participants were split into four groups: exercise plus placebo, exercise…

This completed study examined blood samples from 40 adults to see if high levels of lipoprotein (a), a type of cholesterol, are linked to fewer or different blood vessel repair cells. Participants with high Lp(a) were compared to those with normal levels. The goal was to better u…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…