Influenza

This study looks at how getting the flu vaccine year after year changes your body's immune response. Researchers are testing two types of flu vaccines—a nasal spray (FluMist) and a shot (Flublok)—in 600 adults aged 22 to 50 in Hong Kong. They will measure antibodies and immune ce…

This study tests a nasal spray flu vaccine in 200 people aged 3 to 17. Researchers will measure specific antibodies in the nose to see how well the vaccine works. The goal is to understand the immune response and improve flu prevention.

This large study enrolled over 15,000 U.S. military members to compare three types of licensed flu vaccines: egg-based, recombinant, and cell-culture-based. Participants were randomly assigned to one of the three vaccines over four flu seasons. The main goal is to see which vacci…

This phase 3 study tests a new quadrivalent seasonal influenza vaccine in healthy infants aged 6 months to under 3 years. The goal is to see if the vaccine triggers a strong immune response and is safe compared to an existing flu shot. About 245 children will take part, and resea…

This study tests two experimental vaccines, AZD4117 and AZD5315, designed to protect against certain strains of avian influenza (bird flu), specifically H5N1 and H7N9. Around 405 healthy adults will receive either a vaccine or a placebo to see if the vaccines are safe and trigger…

This early-stage trial is testing whether a new flu vaccine with an adjuvant (a booster ingredient) is safe for adults aged 65 and older. Eighty volunteers will receive a single shot and be monitored for side effects over a year. The study does not yet test if the vaccine prevent…

This early-stage trial is testing the safety of a new quadrivalent influenza vaccine with an adjuvant (a booster ingredient) in adults aged 65 and older. Eighty participants will receive either the new vaccine, a standard flu vaccine, or a placebo. The study monitors side effects…

This study compares high-dose and standard-dose flu vaccines in 396 adults who received a kidney, heart, or liver transplant within the past year. The goal is to see if a higher dose or two doses provide better protection against the flu. Results will help improve vaccine recomme…

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu caused by the H5 virus. Healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a …

This study is testing whether getting two doses of the H5N1 bird flu vaccine 3 weeks apart works as well as getting them 8 weeks apart. It involves 312 healthy adults aged 18-59. The goal is to see which schedule provides better protection against the virus.

This study tests a single dose of a new flu vaccine called OVX836 in about 2,850 healthy adults aged 18 to 59. The goal is to see if it can prevent confirmed influenza A and how safe it is. Participants will be randomly assigned to receive either the vaccine or a placebo.

This study looks at how a nasal flu vaccine works in 60 healthy teenagers aged 14-17. Researchers will measure immune responses in the nose and blood before and after a single dose. The goal is to understand how the vaccine protects against the flu.

This study tests whether a single injection of peramivir can safely treat uncomplicated flu in adults. Participants receive either 150 mg, 300 mg of peramivir, or a placebo, and researchers measure how quickly symptoms improve. The goal is to see if this antiviral shot offers a f…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This early-phase study planned to test whether injecting the seasonal flu vaccine directly into breast tumors could help the immune system attack the cancer. It was designed for women with triple-negative or HER2+ breast cancer who were already scheduled for chemotherapy before s…

This study tests a simple, at-home smell test to see if it can detect COVID-19 infection and track how smell recovers over time. About 1000 adults, including those with known smell loss and healthy volunteers, will use smell cards to rate odor intensity, identification, and discr…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study tests a fast point-of-care PCR test (Spotfire) that quickly identifies whether a respiratory infection is caused by a virus. The goal is to give ER doctors results faster so they can avoid prescribing antibiotics when they won't help. The trial enrolls 200 adults with …

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. Th…

This study compares a 5-day versus a 10-day course of oseltamivir (Tamiflu) to prevent influenza in people exposed to the virus while in the hospital. About 200 adults with flu risk factors will be randomly assigned to one of the two treatment lengths. The goal is to see if the s…

This study tests whether a community-based communication program can increase flu vaccination rates among people over 65 in Can Tho City, Vietnam. The program includes direct counseling, weekly health tips via the Zalo app, and printed leaflets. Researchers will compare vaccinati…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

This study tests whether OM-85 (Broncho-Vaxom), a bacterial extract taken by mouth for 10 days each month, can reduce the number of respiratory infections in children aged 6 months to 5 years who have a history of wheezing. About 525 children will receive either OM-85 or a placeb…

This early-stage trial is testing whether a new long-acting antiviral medicine called CD388 can be safely given at the same time as the high-dose flu vaccine. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. Research…

This study tests whether training school personnel in vaccine communication and providing promotional materials can increase flu vaccination rates among students. About 6,000 students from participating schools will be tracked. The goal is to see if these simple steps lead to mor…

This study tests whether sending a short, encouraging letter from a pharmacist can motivate more adults to get their flu and travel vaccines. Researchers will track vaccination rates and also check if vaccinated people have fewer strokes in the following six months. About 20,000 …

This study tests different text message reminders to see which ones work best at getting people to get their flu vaccine. About 100,000 patients who haven't had their flu shot yet will receive a reminder text before a doctor's visit. The goal is to find simple, effective ways to …

This study tests the safety of giving repeated annual doses of an experimental drug called CD388 to healthy adults. About 400 people who already tolerated one dose without serious side effects will receive two more doses over two years. Researchers will monitor for side effects a…

This study planned to test a single IV dose of peramivir against placebo in teens and adults with uncomplicated flu. The goal was to see if it could shorten flu symptoms like cough, sore throat, and fever. However, the trial was withdrawn before any participants were enrolled, so…

This early-stage study tests different doses of an experimental flu medicine called TRX-100, taken alongside standard care, in 105 people with mild to moderate influenza. The main goals are to check safety and find the best dose. Researchers will also track how well it eases flu …

This study tests a new medicine called ZSP1273 in children aged 2 to 11 who have influenza A. The goal is to see if it can shorten flu symptoms and is safe. About 119 children in China will take either ZSP1273 or the standard flu drug oseltamivir.

This phase 3 trial tests whether the experimental drug ZSP1273 can shorten flu symptoms in teenagers aged 12-17 with uncomplicated influenza A. About 157 participants in China will receive either the drug or a placebo. The main goal is to see how quickly symptoms like cough, feve…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study looks at blood samples from 400 people with and without HIV to understand how aging and HIV infection change the body's immune response to the flu vaccine. Researchers will measure antibody levels and immune cell types to see who responds well to the vaccine and who do…

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study looks at how four different FDA-approved flu vaccines affect the immune system in 50 adults aged 18-50 and 65-80. Researchers will measure antibody levels and memory B cells to see how age and past vaccination history influence the body's response. The goal is to under…

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

This study follows 75 adults aged 65 and older over three to four flu seasons to learn why the flu vaccine becomes less effective as people age. Participants will receive a different FDA-approved flu vaccine each year, and researchers will collect blood, nasal swab, and stool sam…

This study follows 500 children under 18 who tested positive for flu, RSV, or COVID-19. Each child takes a daily nose swab for 14 days to measure how the virus levels change over time. Researchers also check if family members get sick. The goal is to understand when kids are most…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This study follows 200 people who have had the flu to see how their immune system changes over two years. Participants give blood and nasal samples every three months. The goal is to learn how long antibodies last and how they change, which could help create more effective flu va…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study follows about 1,000 adults in the U.S. who test positive for COVID-19 or influenza. Participants fill out surveys about their symptoms and quality of life over six months. The goal is to understand how these illnesses affect daily activities and whether COVID-19 vaccin…

This study compares two flu vaccines: a nasal spray and a standard shot. Researchers will measure immune responses in the nose and blood of 60 healthy adults aged 18-49. The goal is to understand how each vaccine triggers protection and find ways to improve future flu vaccines.

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This trial is studying a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety. Participants will be monitored closely. The study sponsor and current status are not publicly available.

This study looks at whether eating a high-fiber diet (rich in fruits, vegetables, and whole grains) can change the bacteria in your gut and improve how well the flu vaccine works. Researchers will give 31 adults special meals and snacks before they get their flu shot. The main go…

This study looks at whether the bacteria in your gut and what you eat can influence how well the flu vaccine works. Researchers will collect blood and stool samples from 74 adults before and after they get their flu shot. The goal is to find links between gut microbiome diversity…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study looks at how the flu vaccine changes immune cells in the nose and blood. Researchers will collect samples from 30 healthy adults before and after they get the flu shot. The goal is to understand if the vaccine creates 'resident memory' immune cells in the nose, which c…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study tracks how long the flu virus stays in the upper airways of 18 hospitalized adults who are taking oseltamivir (Tamiflu). The goal is to see if antiviral treatment can safely shorten the time patients need to stay in isolation, freeing up hospital rooms during flu seaso…

This study follows 1,500 healthy infants from birth to age 4 to understand how their first encounter with the flu—either through vaccination or natural infection—affects their immune system's response to later flu exposures. Pregnant mothers are enrolled before delivery, and thei…

This study from the University of Pennsylvania looks at whether simply asking people about their intentions to do a health behavior—like getting a flu shot—makes them more likely to actually do it. Researchers are tracking 350 participants to see if measuring intention changes be…

This study looks at how well cancer patients respond to common vaccines like flu, COVID-19, and shingles. Researchers will measure antibody levels before and after vaccination in 250 adults with cancer. The goal is to understand immune responses in this group, not to test a new t…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…