Influenza

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This study is checking the safety of a high-dose flu vaccine called Efluelda in adults aged 65 and older in South Korea. About 670 participants will receive one shot and be monitored for side effects for about a month. The goal is to see how often reactions like injection site pa…

This early-stage trial compares an experimental flu vaccine called H1ssF with the standard seasonal flu vaccine (Flucelvax). About 112 adults aged 18-70 will take part, including some who have had flu shots before and some who have never had one. The main goal is to check safety …

This early-stage trial tests a new influenza vaccine that includes a special booster called BK-01 adjuvant. The goal is to see if it is safe and triggers a strong immune response in adults 18 and older. 160 volunteers will receive either the new vaccine, a standard flu vaccine, o…

This study is checking the safety of a high-dose flu vaccine called Efluelda Tetra in adults aged 65 and older in South Korea. About 670 participants will receive one dose and be monitored for side effects for about a month. The goal is to see how often reactions like injection s…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests whether a single oral dose of TRX-100 can prevent influenza infection in healthy adults aged 18 to 55. Participants will be deliberately exposed to the flu virus in a controlled setting. The trial is randomized, double-blind, and placebo-controlled, meaning neith…

This phase 3 trial will test whether adding low or moderate doses of the corticosteroid methylprednisolone to standard care can lower the death rate in adults with severe influenza pneumonia in the ICU. About 496 participants will be randomly assigned to receive either saline (pl…

This early-stage study tests a single dose of a new drug called AVM0703 in 16 adults with severe breathing failure (ARDS) caused by COVID-19 or the flu. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive the …

This study evaluates a new digital test that people can use at home to detect COVID-19 and influenza A and B from a nasal swab. Participants with symptoms will use the test themselves and compare the results to a standard lab PCR test. The goal is to see if the test is accurate e…

This study will test a new at-home rapid test that checks for flu A, flu B, and COVID-19 using a nasal swab. About 200 people with symptoms will use the test themselves, and their results will be compared to standard lab PCR tests. The goal is to see if the test is accurate and e…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study will test a new at-home diagnostic test that aims to detect five respiratory viruses—COVID-19, influenza A and B, RSV, and rhinovirus—from a single nose swab. About 2,000 people with cold or flu symptoms will provide samples in simulated home environments. The test's a…

This study tests whether a rapid PCR test done right in the clinic can help doctors diagnose and treat acute respiratory infections faster. Over 16,000 adults at risk of severe illness will take part. The goal is to see if this approach lowers rates of respiratory failure and hos…

This trial tests whether offering a needle-free flu vaccine (FLUMIST) for self-administration at home, picked up from a pharmacy, increases flu vaccination rates compared to usual care. Households with children aged 2 to 17 in Burlington, Ontario, are randomly assigned to either …

This phase 3 trial is testing whether a single dose of the antiviral drug sebaloxavir marboxil can prevent influenza in household members (ages 2 and up) who live with someone recently diagnosed with the flu. Participants are randomly assigned to receive either the drug or a plac…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study tests whether a chatbot delivered through WhatsApp can help mothers decide to get their children aged 3-6 vaccinated against seasonal flu. Mothers are randomly assigned to receive either a chatbot that tailors its messages to their readiness to vaccinate or a standard …

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This large trial will study whether flu and pneumonia vaccines can reduce serious flare-ups and medical costs in people aged 45-80 with COPD. About 7,000 participants will be split into four groups: flu vaccine, pneumonia vaccine, both, or no vaccine. Researchers will track lung …

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests two nasal protective devices (Noseguard and Noseguard Night) in 2000 adults to see if they can reduce the risk of catching respiratory infections like COVID-19 and influenza. Participants will use the devices as directed for 8 weeks, and researchers will track in…

This study tests a new flu vaccine in 1,200 adults aged 60 and older to see how well it boosts immunity and if it's safe. Participants receive one dose of either the new vaccine or a current one, and researchers check antibody levels and side effects for 30 days. The goal is to f…

This study tests whether a special fish oil (Omega Cold) can help healthy adults avoid or recover faster from colds, flu, and COVID-19. Four hundred participants aged 18–80 will take either the fish oil or a placebo daily for four months during flu season. They will report any sy…

This trial tests whether simple nudges (reminder messages) and motivational interviewing can increase flu vaccination among 4,050 healthcare workers in Chinese community hospitals. In phase 1, hospitals get either standard nudges, personalized nudges with a chatbot, or no reminde…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study looks at whether a traditional Chinese herbal drink (Xuanfei Jiangzhuo Decoction) can help older adults (60+) recover faster from a COPD flare-up caused by the flu. About 300 participants will either take the herbal drink plus standard flu medicine or standard flu medi…

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

This phase 3 trial tests whether a single dose of baloxavir helps non-hospitalized adults with mild-to-moderate influenza recover faster compared to a placebo. About 264 participants will be enrolled within 5 days of symptoms and tracked until they feel fully recovered. The study…

This study looks at whether changing climate patterns are shifting when winter respiratory viruses, like the flu, peak each year. Researchers will review medical records of 5,000 patients who tested positive for these viruses and compare infection rates with weather data from the…

This study investigates how the immune system inside the nose responds to the FluMist nasal flu vaccine in healthy adults aged 18 to 65. Participants receive a single dose of the vaccine, and researchers collect nasal swabs and gentle saline washes before vaccination and again tw…

This study examines data from up to 70,000 patients hospitalized with respiratory tract infections in Dutch hospitals between 2018 and 2026. Researchers will analyze how long patients stay, how many need intensive care, and the overall costs. The goal is to help improve hospital …

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study looks at how different features of an AI system affect the way primary care doctors diagnose and treat respiratory infections. About 3,000 doctors in China will use a web-based tool with various AI features, such as automated data entry or stepwise medication suggestio…

This study will examine gut bacteria, immune markers, and nutrient levels in 120 children with different respiratory health conditions, including pneumonia and recurrent infections, compared to healthy kids. By analyzing stool samples and health data, researchers hope to understa…

This follow-up study checks if taking TUDCA or fatty acid supplements during a flu vaccine helps older adults (ages 60-70) keep their immunity longer. Researchers will measure antibody levels and immune cells about 8 months after vaccination. No new treatment is given—just one bl…

This study aims to understand how influenza transmits from person to person. Healthy volunteers, called Recipients, will spend time in a controlled environment with people infected with the flu (Donors) while performing everyday activities like playing cards. The study involves d…

This phase 1 trial aims to safely and reliably cause mild flu symptoms in healthy adults using a lab-made H3N2 influenza virus. By carefully monitoring 32 volunteers, researchers hope to establish a controlled human infection model (CHIM) that can be used in future studies to tes…

This study will test if a new health awareness video can teach public transportation drivers in Lebanon about preventing respiratory infections like colds and flu. About 160 drivers will be split into two groups: one watches the health video, the other watches a neutral video abo…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…