Eosinophilic esophagitis

This study tests dupilumab, an injectable drug already used for allergies, in 22 adults and teens with eosinophilic gastritis (stomach inflammation caused by too many white blood cells). The goal is to see if it reduces inflammation and improves symptoms over 6 months to a year. …

This study tests a once-daily pill called vonoprazan against a placebo in 80 adults with eosinophilic esophagitis (EoE), a condition that makes swallowing difficult. The main goal is to see if the drug reduces inflammation in the esophagus after 12 weeks. Researchers will also ch…

This study looks at whether removing four common foods (dairy, wheat, egg, soy) from the diet can help children with eosinophilic esophagitis (EoE). The goal is to reduce symptoms like vomiting and trouble swallowing, and to find which foods trigger the condition. About 64 childr…

This study looks at whether simply removing cow's milk from the diet can control eosinophilic esophagitis (EoE) in children aged 1 to 18. EoE is a condition where the esophagus becomes inflamed, often causing trouble swallowing. The trial will check if this diet change leads to l…

This study compares two treatments for eosinophilic esophagitis (EoE): swallowed budesonide (Eohilia) and injected dupilumab (Dupixent). Researchers want to see which one better improves esophageal diameter and reduces scarring after 12 weeks. The trial enrolls 60 adults with act…

This study looks at how well dupilumab, an already approved drug, works for people with severe eosinophilic esophagitis (EoE) that has caused narrowing of the esophagus. About 23 participants aged 16 and older will receive weekly injections of dupilumab for one year. The goal is …

This study tests an experimental drug called tezepelumab in people aged 12 to 80 with eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing trouble swallowing. Participants receive either the drug or a placebo as a shot under the skin. T…

This study tests an experimental drug called NSI-8226 (solrikitug) in adults with eosinophilic esophagitis, a condition that causes trouble swallowing due to inflamed esophagus. About 184 participants will receive either the drug or a placebo to see if it reduces inflammation and…

This study looks at whether children with eosinophilic esophagitis (EoE) can safely cut their steroid dose in half and still stay in remission. The 50 participants have already achieved remission on a full dose of topical steroids like fluticasone or budesonide. Researchers will …

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests a medication called dupilumab in 69 adults with eosinophilic esophagitis, a condition that makes swallowing difficult due to inflammation and scarring in the esophagus. Participants receive either dupilumab or a placebo for 24 weeks, then everyone gets dupilumab …

This program offers APT-1011, a fluticasone tablet that dissolves in the mouth, to patients aged 12 and older with eosinophilic esophagitis who cannot join other studies or have not responded to available treatments. The goal is to provide access until the drug is commercially av…

This study tests a new, less invasive device called the Esophageal String Test (EST) to diagnose and monitor a rare condition called eosinophilic esophagitis (EoE). Instead of using a scope with a biopsy, patients swallow a small string that collects samples from the esophagus. T…

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study gathers information from 300 children with eosinophilic esophagitis (EoE), a chronic allergic condition that inflames the esophagus. Researchers aim to better understand what causes EoE, how it relates to other allergies, and which treatments work best. No new treatmen…

This study aims to find non-invasive markers in blood and urine that can show whether inflammation is present in the esophagus of children with eosinophilic esophagitis (EoE). Researchers will compare these markers with tissue samples from biopsies to see if they can reliably det…

This study collects blood, urine, and tissue samples from 330 adults with advanced lung or head and neck cancer to improve precision medicine. Researchers will analyze genetic changes in these samples and grow some tumors in mice to compare DNA. The goal is to refine liquid biops…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study aimed to test a special camera capsule that takes detailed images of the esophagus to diagnose eosinophilic esophagitis and Barrett esophagus. It planned to compare the capsule's images with standard biopsy results. However, the study was withdrawn before any participa…

This study tests a new, swallowable camera capsule that takes detailed images of the esophagus. It includes people with eosinophilic esophagitis and healthy volunteers. The goal is to see if the capsule works well and is comfortable to use.

This study was designed to check if swallowed corticosteroids, used to treat eosinophilic esophagitis (EoE) in children aged 5-12, affect bone density and growth over one year. It planned to compare these children to healthy age-matched controls. However, the study was withdrawn …

This research study aims to understand why some people develop food allergies and others outgrow them. Researchers at Children's Hospital of Philadelphia will collect blood samples from 5,300 people (ages 1 month to 65 years) with and without food allergies to study immune cells …