Coronary microvascular disorder

This early study tests a device called the A-FLUX Reducer, which is implanted into a vein in the heart to help blood flow. It is for people with chest pain caused by problems in the heart's tiny blood vessels (microvascular dysfunction). The study will enroll 30 adults and focus …

This study tests a special balloon coated with a drug (paclitaxel) to open blocked heart arteries. About 1,200 adults with coronary artery disease will receive either the Prevail balloon or another similar balloon. The goal is to see if the Prevail balloon is safe and works well …

This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo hea…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests a new wireless pressure microcatheter to diagnose coronary microvascular dysfunction (CMD) in people with chest pain but no major artery blockages. Researchers will compare the device's measurements to heart MRI scans in 114 participants. If accurate, it could of…

This study tests whether a magnetocardiography (MCG) device can detect reduced blood flow to the heart muscle in people with acute chest pain but no major artery blockages. About 3,786 participants will undergo MCG scanning, and results will be compared to a standard ultrasound t…

This study tests whether a new software-based method called Angio-IMR can diagnose coronary microvascular disease (blockages in tiny heart arteries) as accurately as the current standard test that uses a pressure wire inside the artery. About 192 adults with stable chest pain or …

This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve…

This pilot study is testing whether advanced CT and MRI scans can diagnose coronary microvascular disease (CMD) without needing an invasive angiogram. CMD affects the heart's tiny blood vessels and causes chest pain in many people with no major artery blockages. Researchers will …

This study explores whether a simple, non-invasive eye scan (OCT-A) can diagnose microvascular angina, a heart condition affecting about 112 million people worldwide. Currently, diagnosis requires an invasive heart procedure to measure microcirculatory resistance. Researchers wil…

This study tests whether artificial intelligence and special ECG monitoring can improve diagnosis of angina in people whose arteries are not blocked. Researchers will use a Holter monitor at home and an internal ECG during a procedure to detect subtle signs of heart muscle strain…

This trial tests whether a 24-week personalized program called MICROFIT—combining high-intensity interval training with a personal trainer and Mediterranean-style dietary advice—is feasible for people with microvascular coronary dysfunction, a condition where small heart blood ve…

This study tests whether the drug vericiguat can improve blood flow in the tiny vessels of the heart and reduce chest pain. About 94 adults aged 40-75 with stable chest pain but no major blockages will take the drug or a placebo. The main goal is to see if heart blood flow improv…

This study tests a new device called the A-FLUX Coronary Sinus Reducer to see if it can safely improve chest pain or discomfort in people with coronary microvascular dysfunction (CMD), a condition where tiny heart vessels don't work properly. About 30 adults with persistent sympt…

This study tests a drug called macitentan in 40 adults with chest pain that isn't caused by blocked arteries (non-obstructive angina). The goal is to see if the drug improves blood flow in the tiny heart vessels and reduces chest pain. Participants will take macitentan for 4 week…

This study will enroll 246 people who have had a heart stent but still experience chest pain. Researchers will use a detailed diagnostic approach during a heart catheterization to identify whether the pain is due to new blockages, incomplete treatment, or other issues. The goal i…

This study looks at whether CD34+ stem cells, which help maintain tiny blood vessels in the heart, are linked to how well the heart recovers in people with Takotsubo syndrome (also known as broken heart syndrome). Researchers will measure heart function in 40 participants at the …

This study looks at 150 adults who had a heart attack but whose main heart arteries were not blocked. Researchers will use special imaging and pressure tests to check for problems in the tiny blood vessels of the heart. The goal is to see if these microvascular issues lead to wor…

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their do…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study uses a special heart MRI to see if a device called a coronary sinus reducer can improve blood flow in patients with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (small vessel disease). The device is implanted to reroute …

This study looks at how mental stress impacts the small blood vessels of the heart in postmenopausal women with coronary microvascular dysfunction (CMD). Researchers will measure heart activity, stress responses, and daily symptoms in 150 women using imaging, questionnaires, and …

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study is a registry that will follow 3000 people who had a heart attack but no blocked arteries (MINOCA). The goal is to learn more about this condition, improve diagnosis, and understand long-term outcomes. Participants will be tracked over time to see how they are doing an…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …