Coronary microvascular disorder

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This trial tests whether a multi-domain lifestyle program—including diet, exercise, stress management, and tailored medication—can reduce chest pain and improve quality of life in people with coronary microvascular dysfunction (small vessel heart disease). About 120 patients will…

This study tests whether a 36-session cardiac rehabilitation program (exercise plus education) can improve quality of life in people with coronary microvascular disease, a condition where small heart vessels don't work properly. About 204 participants with angina and confirmed mi…

This study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and heart damage in people with Long COVID who have ongoing heart inflammation. About 279 adults with heart inflammation seen on MRI will receive either the drug combo or a …

This study tests a device called a coronary sinus reducer in 50 people with chest pain caused by coronary microvascular disease, a condition where small heart vessels don't work properly. The device is implanted to narrow a heart vein, which may improve blood flow. Half the parti…

This study is testing a special balloon coated with a drug (paclitaxel) and natural substances (shellac and vitamin E) to treat small coronary artery disease. The balloon is inflated inside the narrowed artery to deliver the drug and help keep it open. Researchers will follow 3,0…

This trial is testing whether a new PET imaging tracer, 18F-flurpiridaz, can detect coronary artery disease as accurately as the current standard, 82Rb-chloride. The study will involve 60 adults scheduled for a clinically indicated PET scan. Researchers will compare the diagnosti…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether a special heart function test can guide treatment to improve symptoms and quality of life. 108 participants will be randomly assigned to either treatment guided by the tes…

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This study compares two procedures—rotational atherectomy and intravascular lithotripsy—used to treat severe calcium deposits in heart arteries. The goal is to see how each technique affects the tiny blood vessels (microcirculation) of the heart and whether one leads to better lo…

This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and …

This study is a registry that follows over 1,000 people with suspected ischemic heart disease. Doctors use special tests during heart catheterization to measure blood flow and pressure in the heart's small vessels. The goal is to see if these measurements can predict future heart…

This study watches 25 people with breast or lung cancer who are getting immune checkpoint inhibitor therapy. Researchers use heart scans and blood tests to see if the treatment harms the heart's tiny blood vessels. No new drugs are given; the goal is to learn how to better protec…

This registry follows over 670 people with chest pain and non-blocked arteries to study how well tiny heart vessels (microcirculation) work. Participants complete questionnaires about their symptoms and are tracked for up to 5 years for heart events like heart attacks or strokes.…

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study looks at why some women with chest pain or signs of heart disease have normal-looking large arteries but still have problems with tiny blood vessels in the heart. Researchers will measure platelet activity and inflammation during a heart catheterization to see if these…

This study aimed to see if a simple blood test could find blockages in the small blood vessels of the heart in people who have had a heart transplant. Participants would have had blood draws every three months for a year, and their medical records would have been reviewed for thr…

This study looks at whether a special heart MRI can find problems in the small arteries of women who have chest pain but no major blockages. About 375 women will get both a standard angiogram and a cardiac MRI to compare results. The goal is to see if the MRI can detect hidden he…