Could a tiny mesh device ease stubborn chest pain?

NCT ID NCT06898541

ENROLLING_BY_INVITATION Disease control Sponsor: UMC Utrecht Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device called a coronary sinus reducer in 50 people with chest pain caused by coronary microvascular disease, a condition where small heart vessels don't work properly. The device is implanted to narrow a heart vein, which may improve blood flow. Half the participants get the real device, half get a sham procedure, and researchers will compare changes in blood flow and daily chest pain episodes after 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Coronary sinus reducer (a small mesh device implanted in a heart vein)
What this could lead to: If it works, this could provide a new treatment option for people with chest pain caused by small heart vessel disease who have few other choices.
What could go wrong: This is a small early-stage trial with only 50 participants, so results may not apply to everyone. The procedure involves implanting a device, which carries risks like infection or vessel damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris Angina, Stable coronary microvascular disorder intermediate coronary syndrome Microvascular Angina

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGINA (STABLE) CORONARY MICROVASCULAR DISEASE

Contacts and locations

Locations

Maasstad Ziekenhuis

Rotterdam, Netherlands
UMC Utrecht

Utrecht, 3584CX, Netherlands

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