Exercise program aims to ease chest pain in hidden heart condition

NCT ID NCT05810051

Ongoing Disease control Sponsor: CoreAalst BV Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 36-session cardiac rehabilitation program (exercise plus education) can improve quality of life in people with coronary microvascular disease, a condition where small heart vessels don't work properly. About 204 participants with angina and confirmed microvascular dysfunction will be randomly assigned to either standard medical care or standard care plus the rehab program. The main goal is to see if the rehab group reports better quality of life and fewer angina symptoms after 4 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cardiac rehabilitation (exercise and education program)
What this could lead to: If it works, this could show that a structured exercise program improves daily life and reduces angina symptoms for people with coronary microvascular disease.
What could go wrong: This is a single-center trial with a relatively short follow-up (4 months), so results may not apply broadly. The intervention is behavioral, so adherence and long-term benefits are uncertain.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder Microvascular Angina

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY MICROVASCULAR DISEASE

Contacts and locations

Locations

OLV Aalst

Aalst, East-Flanders, 9300, Belgium

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