Bacterial sexually transmitted disease

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This trial tests two approved antibiotics—azithromycin (a single dose) and doxycycline (twice daily for a week)—to see which is more effective at curing genital chlamydia in young people aged 12-21 living in youth correctional facilities. Participants provide urine samples over a…

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This completed phase 4 trial tested whether taking doxycycline for 3 days works as well as the usual 7-day course for treating chlamydia. About 526 men and women with confirmed chlamydia took either a 3-day or 7-day regimen, with placebo pills used to keep the study blinded. Part…

This study looked at whether it is safe to stop giving annual azithromycin to communities with low levels of trachoma, an eye infection that can cause blindness. Over 3,900 people in Niger took part. Researchers compared stopping treatment after at least 5 years versus continuing…

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested whether a vaccine already approved for meningitis B (Bexsero) can also protect against gonorrhea infection. Healthy men aged 18–35 received either the meningitis vaccine or a placebo, then were exposed to the gonorrhea bacteria in a controlled setting. The goal …

This phase 3 trial tested a new antibiotic called zoliflodacin, taken as a single oral dose, against the standard treatment of an injection plus pills for uncomplicated gonorrhea. Over 1,000 participants were enrolled to see if the new pill works as well and is safe. If successfu…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.

This study looked at better ways to screen teenagers (ages 15-21) for chlamydia and gonorrhea when they visit emergency departments. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to find the most effective and cos…

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tests whether the meningitis vaccine Bexsero can also prevent gonorrhea, a common sexually transmitted infection. About 2,600 adults aged 18-50 who are at higher risk for gonorrhea will receive either the vaccine or a placebo. Researchers will track how many get infect…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This study tested whether using an antibacterial mouthwash every day could lower the chance of getting gonorrhea in the throat. Researchers recruited 89 HIV-positive and HIV-negative men at high risk. Participants gargled with either Listerine or a placebo mouthwash daily. The st…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This large study in rural Ethiopia looked at whether providing clean water, sanitation, and face-washing education can reduce trachoma infections in communities that have already received many rounds of antibiotics. Over 47,000 people from 40 communities took part. The goal is to…

This study looked at health insurance records of over 81,000 people aged 14 to 44 in Germany to see how often chlamydia leads to serious health problems like infertility or pelvic disease, and how much it costs the healthcare system. Researchers tracked infections, complications,…

This study looked at how much doxycycline builds up in body tissues after taking it daily for 7 days. Researchers measured levels in rectal and vaginal tissues to help design better ways to prevent bacterial sexually transmitted infections (STIs). 24 healthy adults took part, inc…

This study tested whether a pay-it-forward approach—where one person's donation covers testing for the next person—could increase gonorrhea and chlamydia testing among men in China. Over 1,200 men who had sex in the past year but hadn't been tested recently took part. The goal wa…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…