University Of Miami

This study tests a new way to treat prostate cancer using MRI-guided radiation that targets only the tumor, not the whole prostate. For early-stage patients, a single high-dose session may be enough to cure the cancer. For higher-risk patients, the focused dose is followed by sta…

This study looks at whether cooling the body to a mild 33°C (about 91°F) within 24 hours of a severe neck spinal cord injury can improve nerve function and recovery. Researchers will compare 120 adults who receive this cooling treatment to similar patients who did not. The goal i…

This study is testing whether giving chemotherapy first, followed by a higher dose of targeted radiation, can completely eliminate cancer in people with locally advanced rectal cancer. The goal is to see if this approach is safe and effective enough to avoid the need for surgery.…

This study tests a shorter course of a combination of drugs (BrECADD) in people with advanced Hodgkin lymphoma. The goal is to see if this approach can control the disease with fewer side effects. About 48 adults aged 18 to 60 will take part, and researchers will also check if a …

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and can shrink or control relapsed brain tumors in people under 22. About 20 participants with specific types of glioma will receive the treatme…

This study looks at whether monitoring the immune response to cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to use immune system testi…

This study tests whether combining the drug tebentafusp with a liver-directed radiation procedure (Y-90 radioembolization) can help control metastatic uveal melanoma that has spread to the liver. About 30 adults with this condition will receive the combination therapy. The goal i…

This study tests whether combining the drug axatilimab with a blood-filtering treatment called ECP can help people with chronic graft-versus-host disease (cGVHD), a condition where donor immune cells attack the recipient's body after a stem cell transplant. About 49 participants …

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm count …

This study tests whether a diet rich in anti-inflammatory American foods (like salmon, oatmeal, and grilled vegetables) can help people with ulcerative colitis achieve remission. About 122 participants aged 16-75 with mild to moderate symptoms will follow the diet and be monitore…

This pilot study tests whether combining a weight-loss medication (tirzepatide) with a special diet can help control mild Crohn's disease in people who are already on biologic therapy. The study includes 24 adults with a BMI of 27 or higher. The goal is to see if this approach is…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink or control recurrent endometrial cancer that did not respond to initial chemotherapy and immunotherapy. About 46 adults with a specific type of uterine cancer (mismatch repair proficient) will receive th…

This study tests whether briefly soaking a corneal graft in a plasma rich in growth factors (PRGF) before transplant surgery can reduce the loss of important cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal edema who need a corneal transpla…

This study is testing a new mobile health system that sends text reminders and offers support to help women with HIV stick to their treatment plan. The goal is to reduce stigma and medical mistrust while improving clinic attendance and medication adherence. About 80 women will ta…

This study tests a new therapy that combines a brain-computer interface with spinal cord stimulation to help people with incomplete spinal cord injury walk better. The therapy reads brain signals and sends them to the spine to improve leg movement. The trial involves 12 adults ag…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their depression and HIV viral levels improve within a year. Ten clinics in Cape Town, South …

This study gives plant-based foods like fruits, vegetables, and whole grains to low-income families who struggle to get enough healthy food. Participants will track what they eat each week. The goal is to see if this food prescription program helps families eat better and feel le…

This study tests whether a combination of three drugs (selinexor, venetoclax, and dexamethasone) can better control a specific type of multiple myeloma that has come back or not responded to treatment. About 33 adults with a genetic marker called t(11;14) will receive the drugs i…

This study tests whether combining two drugs, epcoritamab and loncastuximab tesirine, is safe and effective for people with large B-cell lymphoma that has come back or stopped responding to treatment. About 26 adults will receive the drug combination, and researchers will monitor…

This study looks at whether eating a controlled Mediterranean-style diet for a short time before prostate cancer surgery can lower insulin levels and improve other health measures. About 20 men scheduled for prostate removal will take part. Researchers will check blood and tissue…

This study looks at whether a diet with longer overnight fasting and Mediterranean-style eating is practical for people with multiple myeloma or its early forms (MGUS or smoldering myeloma). About 120 adults will try this approach to see if they can stick with it and find it help…

This study tests whether adding elranatamab to standard drugs (lenalidomide and dexamethasone) can deeply reduce or eliminate cancer cells in people newly diagnosed with multiple myeloma. About 104 participants will receive the combination and be monitored for response. The goal …

This study looks at how well women of African ancestry with ovarian cancer tolerate a maintenance drug called niraparib after initial treatment. Niraparib works by blocking cancer cells from repairing their DNA, which can slow or stop tumor growth. Researchers will also study how…

This study tests whether DNA changes in the KIT gene can help doctors choose the right drug for people with advanced gastrointestinal stromal tumor (GIST). About 48 adults who have already tried imatinib will receive either sunitinib or regorafenib based on their tumor's DNA. The…

This study looks at whether a drug called collagenase (CCH) is safe and works for men with Peyronie's disease who already tried platelet-rich plasma (PRP) injections. About 22 men with a penile curve between 30 and 90 degrees will get CCH injections into the plaque. The main goal…

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers, safety managers, and company leaders will take part. The goal is to find the most effective and cost-effectiv…

This study tests whether a therapy called functional electrical stimulation (FES) can improve arm and hand movement in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove system to stimulate muscles while participants practice tasks. The goal i…

This study tests whether combining the drug regorafenib with a type of internal radiation (Y-90) can control advanced liver cancer that cannot be removed by surgery. About 30 adults with unresectable hepatocellular carcinoma will receive the combination. The goal is to see how ma…

This study tests a drug called loncastuximab tesirine in 50 adults with marginal zone lymphoma that has returned or not responded to prior therapy. The drug is designed to deliver a toxin directly to cancer cells. Researchers will measure how many participants achieve complete re…

This study tests a counseling program designed to help Black women living with HIV take their medication regularly and achieve viral suppression. Participants must be Black, cis-gender women aged 18 or older, with a history of trauma and recent unsuppressed viral load. The progra…

This study tests a web and mobile program called Healthy Together ("Juntos") for Hispanic teens aged 12-15 and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will use the program to see if it helps teens stay…

This study looks at two methods for people already taking PrEP (a daily pill to prevent HIV) to share HIV self-test kits and PrEP information with their friends and family. The goal is to see which method—directly giving out test kits or using referral codes—gets more people test…

This study tests a program designed to help parents support their Hispanic LGBTQ+ teenagers. The goal is to prevent or reduce drug use and symptoms of depression. About 306 teens aged 13-19 and their families will take part. The program focuses on improving family communication, …

This study tests a program called JUNTOS, where HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network helps more people get the care they need. About 245 participants and counselors will take p…

This study compares two ways of providing HIV prevention medication, hepatitis C treatment, and substance use disorder care through telehealth to 350 people who inject drugs. Participants must be HIV-negative and have exchanged syringes recently. The goal is to see which approach…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study tests a new way to help Latinx men at risk for HIV start and stick with PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 ci…

This study tests a brief online program called Project Independence for caregivers of autistic youth ages 10 to 14. The program gives caregivers practical tools to help their child become more independent in daily routines like dressing or chores. About 70 caregivers will be rand…

This study tests a new digital game designed to help parents and children play together in a fun, bonding way. About 30 parent-child pairs will try the game and report on their relationship and parenting confidence. The goal is to see if digital tools can strengthen family connec…

This study looks at whether a Mediterranean diet and exercise program can help lymphoma patients finish their chemotherapy and feel better during treatment. About 140 adults with Hodgkin or non-Hodgkin lymphoma who are starting chemotherapy will take part. The goal is to see if t…

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having these surgeries will be randomly assigned to one of the two listening options.…

This study compares how well two different incision types heal after hip replacement surgery in obese patients. One incision is a curved 'bikini' cut, and the other is a straight vertical cut. Researchers will measure wound healing time, scar appearance, and patient satisfaction …

This study tests whether community health workers can help people with moderate-to-severe sleep apnea use their breathing machines more consistently. About 48 adults who have never used a PAP machine before will receive either motivational support from a health worker or usual ca…

This study tests a short, 30-minute online program designed to help caregivers (parents or guardians) of children aged 4-10 with anxiety. The program is being adapted for Latin, Haitian, and Haitian-American families. Researchers will measure changes in caregiver anxiety and how …

This study tests whether the nerve pain medication duloxetine can reduce the amount of strong painkillers (opioids) needed after total hip replacement. About 64 adults having hip surgery will receive either duloxetine or a placebo before and after their operation. The main goal i…

This study is testing a Chinese herbal cream (with 1% menthol) to temporarily relieve pain and itching caused by radiation therapy. The cream is an over-the-counter product. Researchers will enroll 40 women with breast cancer who have had a mastectomy and are about to start radia…

This study explores whether combining magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation can improve hand, leg, and trunk function in people with spinal cord injury. About 25 participants, including those with injury and healthy volunteers, wil…

This study tests whether a behavioral therapy called CBIT can reduce tics and improve quality of life in 200 youth with tic disorders (like Tourette's) and related emotional problems. Participants will receive CBIT sessions, and researchers will track changes in tic severity, urg…

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney surgery for cancer, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NS…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a tailored nutrition and exercise program helps them eat better and move more. About 306 survivors and healthcare providers will take part. The goal is to see if survivors …

This study explores whether using virtual reality (VR) can lower anxiety and improve the treatment experience for cancer patients receiving radiotherapy. About 150 adults with cancer who are getting radiation at the University of Miami will be randomly assigned to watch a standar…

This small study tests whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injury. Sixteen participants will receive the stimulation and be monitored for side effects and completion of t…

This study tests if Botox can reduce light sensitivity (photophobia) in people who have had a traumatic brain injury. Researchers will measure changes in pain and visual function in 50 adults with chronic light sensitivity. The goal is to find a new treatment to ease this common …

This study tests whether combining body illusions (tricks that change how you perceive your body) with a gentle brain stimulation technique can reduce nerve pain and improve sensation in people with spinal cord injury. About 30 adults with long-term nerve pain will participate. T…

This study looks at a new, low-risk therapy called passive neurosensory reintegration training (PNRT) for people with mild traumatic brain injury (mTBI) who still have symptoms like dizziness or trouble thinking. Researchers will test if the therapy is safe and helps improve thes…

This study tests whether a magnesium supplement called Magnesium-L-Threonate can help people sleep better and feel less pain after total knee or hip replacement surgery. About 64 adults having surgery at the University of Miami will take the supplement or a placebo. The goal is t…

This study looks at whether adding a community health worker (called a "natural helper") to standard parent-child therapy helps families stick with the program and see better results. About 300 families with children aged 2 to 12 who have behavior problems or a history of abuse w…

This study compares three types of support for parents who lost a child to cancer. It tests whether Meaning-Centered Grief Therapy, Supportive Counseling, or Enhanced Usual Care better reduces grief and depression. About 415 parents with high grief levels will take part. The goal…

This study looks at whether a structured exercise program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play at least one hour of video games per wee…

This study tests whether using ice packs, medicated witch-hazel pads, and a numbing spray can reduce pain after vaginal surgery. About 70 women having perineal repair will be randomly assigned to receive this routine or standard care. The goal is to see if this simple, at-home ap…

This study looks at whether low-load or high-load resistance training works better for improving muscle strength and everyday tasks in people with Parkinson's disease. Researchers will enroll 60 older adults with mild to moderate Parkinson's. Participants will do either light or …

This study is testing a therapy program called Unified Protocol for children and teens (ages 7-17) with anxiety or depression, along with their parents. The program uses cognitive-behavioral techniques to help manage emotions. Researchers will measure changes in symptoms and pare…

This study tests whether deep brain stimulation (DBS) can improve walking in people with spinal cord injury who still have some movement but cannot walk well on their own. Six adults aged 22 to 70 who have been injured for at least one year will receive DBS to a brain area called…

This study looks at sleep habits in people with gastrointestinal cancer and their sleep partners (like a spouse). It tests two different programs to help improve sleep quality and reduce insomnia. About 152 patient-partner pairs will join, and the study tracks sleep changes over …

This study tests whether adding radiofrequency microneedling to a standard KTP laser treatment works better for rosacea than laser alone. Twenty adults with rosacea will have each side of their face treated differently to compare results. The goal is to reduce redness, bumps, and…

This study looks at whether using a nasal high-flow device during a 6-minute walk test helps people with COPD walk farther and feel less breathless. About 30 adults with COPD who use little or no extra oxygen will take part. Researchers will compare how far they walk and how hard…

This study tests whether a special breathing tube (McMurray Enhanced Airway) can prevent low oxygen levels in patients sedated for a heart ultrasound. About 50 adults will be randomly assigned to receive either the new device or standard oxygen through a nose tube. The goal is to…

This study looks at whether a structured exercise program can help children, teens, and young adults (ages 12-39) with sarcoma complete more of their planned chemotherapy. Participants will either exercise or receive standard care. The goal is to see if exercise is feasible and h…

This study looks at whether a simple blood test that measures tumor DNA (ctDNA) can tell doctors within weeks if chemotherapy is shrinking a patient's pancreatic cancer. Currently, doctors wait about 8 weeks for a scan to see if treatment is working. The goal is to see if the blo…

This study looks at how sleep and exercise habits may affect the risk of dementia in 30 adults who already have memory or concentration problems. Participants will wear a headband and a Fitbit to track sleep and heart health, and provide blood and urine samples. The goal is to un…

This study looks at how much fluid is needed to fully clean an infected knee replacement during a special surgery called DAIR. About 20 adults having knee revision surgery will take part. Doctors will use a blue dye to track contamination and take photos every 2 liters until the …

This study follows healthy people who have a family history and genetic risk for ALS, but no symptoms yet. Researchers want to learn what early changes happen before ALS begins and what factors increase risk. Participants will travel to Miami for regular check-ups over several ye…

This study looks at how to help head and neck cancer patients get nutritional counseling and exercise programs before and during radiation therapy. Researchers want to understand what helps or prevents patients from using these services. The goal is to make prehabilitation progra…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and let a GPS app run for four months. The goal is to understand these connections better, not to test any treatment.

This study tests a special MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. About 30 adults with suspected or confirmed gliomas will get an MRI before their planned biopsy or tumor removal. The MRI results will be compared with lab…

This study looks at how eating food changes the way the brain and stomach talk to each other in people with and without spinal cord injury (SCI). Researchers will measure brain and stomach signals in 28 adults to see if SCI affects this gut-brain connection. The goal is to better…

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens to see how their cannabis habits relate to their mood and thinking. The goal is to better understand the connection, not to test a new treatment.

This study looks at how body composition and diet affect chronic pain and inflammation in people with spinal cord injury. Researchers will measure pain sensitivity and blood markers of inflammation after participants eat a high-fat or moderate-fat meal. The goal is to understand …

This study is testing a mobile app called EveryDose that helps cancer patients remember to take their oral chemotherapy pills on time. About 25 adults with cancer who are starting a new oral chemo drug will use the app for 12 weeks. Researchers will track how often patients use t…

This study aims to see if a blood test that measures endotoxin levels can help predict which patients will develop infections after kidney stone surgery. Researchers will enroll 150 adults undergoing this surgery and track their endotoxin levels before and after the procedure. Th…

This study collects blood samples from people receiving stem-cell transplants for blood cancers and from their donors. Researchers will analyze these samples to understand how the immune system recovers after transplant and why some patients develop graft-versus-host disease. The…

This study looks at how the drug sirolimus affects genes inside brain aneurysms. Researchers will compare gene activity in aneurysm tissue and blood samples from 80 adults who are already scheduled for aneurysm treatment. The goal is to learn more about the disease, not to test a…

This study looks at two different ways to check for swallowing problems after a stroke. It will compare a standard test with a non-standard one to see which better finds the risk of food or liquid going into the lungs. About 50 adults who recently had a stroke will take part. The…

This study aims to see if a specially designed education module helps people with spinal cord injury learn about their increased risk for heart disease, obesity, and related health problems. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure chang…

This study looks at how vaping may harm blood vessels, especially in the lungs. Researchers will compare vapers and healthy non-vapers aged 18-40 to detect early signs of damage. The goal is to understand risks and improve early detection.

This study looks at two different ways to do power training in healthy adults aged 50 to 90. The goal is to find which method works best to improve strength and walking speed. Participants will do exercises and be tested on their muscle power and mobility.

This study looks at whether unconscious patients with brain injuries show brain activity when they hear music or language. Researchers use a simple bedside EEG test to measure this. The goal is to see if this brain activity can predict who will wake up and recover better. The stu…

This study compares two types of anesthesia—general (you are fully asleep) and spinal (you are awake but numb from the waist down)—for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2…

This study tests whether brain signals can be used to trigger spinal cord stimulation and improve hand function in people with chronic spinal cord injury. Three adults with SCI will use a brain-computer interface to control stimulation while performing hand tasks. The goal is to …

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea, measuring how fat cells release substances and affect energy and sugar use. The goal is to better unde…

This study uses special lung scans to measure how air and blood move through the lungs of adults with asthma before and after taking common inhalers. Researchers want to understand how these medications improve lung function at a detailed level. The study involves 40 adults aged …

This study looks at how services from Blood Cancer United (formerly The Leukemia & Lymphoma Society) affect people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will track 400 patients over time to see if the organization helps with access to care, quality …

This study tests whether adding touch sensations (vibrations) to virtual reality lessons can help children learn letters, sounds, and spelling. About 60 students aged 6 and up will use special gloves while doing reading tasks in VR. The goal is to see if feeling the letters impro…

This study looks at how much Hispanic/Latinx head and neck cancer survivors know about lung cancer screening and what stops them from getting screened. Researchers will use surveys and interviews with about 44 people. The goal is to find ways to improve screening rates in this gr…

This pilot study looks at whether reducing alcohol and taking probiotics can improve thinking skills and brain energy use in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to drink less and take either a probiotic or a placebo pill. The goal…

This study looks at whether switching from daily glaucoma eye drops to a long-lasting injectable implant (Durysta) can reduce inflammation on the eye's surface. Researchers will measure a marker of inflammation called caspase-1 in 20 adults with open-angle glaucoma or ocular hype…

This study is a gateway for people with ALS, their family members, and healthy volunteers to join various research projects. The goal is to gather information and samples to help scientists better understand ALS and related diseases. Participants must be at least 18 years old.

This study looks at how well people from underrepresented groups (Black and non-White Hispanic) with heart disease or related conditions can stick with a clinical trial done mostly from home using smartphones. The goal is to find ways to make future trials more inclusive and easi…

This study tests a new approach called ACCESS to help syringe service programs offer routine HIV and Hepatitis C testing to people who inject drugs. The goal is to see if providing funding and support helps these programs test more people and connect them to care. About 40 progra…

This study looks at whether community health workers can help people with non-medical issues that affect health, like finding insurance or a regular doctor. About 900 adults in Florida will either get help from a community health worker or just read self-help materials. Researche…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study collects information from the medical records of 1,200 people with ALS and related conditions. The goal is to learn more about these diseases and improve future research. Participants must receive care at a clinic that uses Epic electronic health records and speak Engl…

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will analyze blood and kidney tissue samples taken before and after the transplant to find the root cause. …

This study looks at how eating affects metabolism and heart health in men with and without spinal cord injury (SCI). Researchers will measure how much energy the body uses after a meal and how hungry participants feel. The goal is to understand these differences to improve future…

This study looks at how standard radiation treatment for prostate cancer changes MRI and PET scans, and how those changes relate to tumor cells in the blood. About 144 men with prostate cancer will have scans and blood tests before, during, and up to 2.5 years after treatment. Th…