University Of Kansas Medical Center

This study looks at whether the number of immune cells in and around a triple-negative breast cancer tumor can help doctors choose the best chemotherapy and immunotherapy before surgery. About 139 women with early-stage breast cancer will receive treatment tailored to their immun…

This study looks at whether starting with a parent-only weight loss program, then adding a parent-child program, works better than the parent-child program alone. About 480 rural families with an overweight child (ages 6-11) and a parent with overweight will participate through v…

This study tests a drug called sacituzumab govitecan in 15 people with advanced bile duct cancer that has spread or come back. The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a toxic payload to kill them. The main goal is to see how many pa…

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program over Zoom plus quarterly team meetings with their doctor and a lifestyle coach. Researchers…

This early-stage trial tests the safety and best dose of combining two drugs, alpelisib and sacituzumab govitecan, for people with advanced HER2-negative breast cancer that has spread or come back. The study includes 18 adults with this type of cancer. The main goal is to find th…

This study aimed to see if the drug Rituximab could help people with a nerve disease called CIDP stop their current medications and achieve long-term remission. Researchers planned to treat 48 patients in three groups based on specific antibodies. However, the study was withdrawn…

This phase 3 trial tests whether sirolimus, a drug used in organ transplants, can slow or stop muscle decline in people with inclusion body myositis (IBM), a rare muscle disease. About 140 adults aged 45 and older will take sirolimus or a placebo for 84 weeks. The study measures …

This study tests whether combining two drugs, regorafenib and durvalumab, can help people with advanced biliary tract cancer that has stopped responding to chemotherapy. About 40 participants will receive the treatment to see if it shrinks tumors or slows disease progression. The…

This study looks at whether a combination of two hormones (bazedoxifene and conjugated estrogens) can reduce breast cancer risk in women going through menopause who also have hot flashes. About 120 women at higher risk for breast cancer will either receive the treatment for 6 mon…

This study explores whether heat therapy can improve how the body and brain handle sugar in healthy older adults (65+) who are at risk for Alzheimer's disease. Researchers will measure blood sugar control and brain energy use in 60 participants to see if heat treatments offer a s…

This small study looks at whether whey protein supplements can increase antioxidant levels in the brain and improve physical function, body composition, and thinking skills in older adults who are starting to become frail. Twenty pre-frail volunteers aged 65 to 85 will take whey …

This study looks at whether using a device that sends mild electrical pulses to the muscles (called NMES) can help people regain strength in their leg after ACL reconstruction surgery. Researchers will compare the strength and size of the muscles in the operated leg to the health…

This study tests an online training program for nursing home staff that teaches better communication with residents who have Alzheimer's or other dementias. The goal is to reduce behavioral symptoms like agitation and rejection of care. Over 5,000 staff from nursing homes across …

This study compares two treatments for chronic low back pain caused by facet joints: standard radiofrequency ablation (RFA), which burns pain-signaling nerves, and a newer therapy called iovera°, which freezes those nerves temporarily without causing permanent damage. The goal is…

This study looks at why some people on statins may not get the full benefits of exercise. Researchers will have 5 adults who take high-dose atorvastatin do supervised exercise for 6 weeks. They will measure changes in fitness and link them to each person's genetic makeup. The goa…

This study is not testing a treatment but is working to make future drug trials for facioscapulohumeral muscular dystrophy (FSHD) faster and more effective. Researchers are testing two new measurement tools and fine-tuning who can join future studies. About 324 adults with FSHD f…

This study creates a collection of blood samples, health records, and scans from 100 adults who had COVID-19. Researchers will use this information to study recovery and long-term effects. Participants are seen during follow-up visits at the University of Kansas Medical Center.

This study looks at how tirzepatide, a weight-loss drug, changes breast tissue and blood markers linked to breast cancer risk. About 20 women with obesity and other breast cancer risk factors will take tirzepatide for 3-6 months. Researchers will measure changes in breast density…

This study looks at whether taking a CT scan while standing up gives doctors better information about spine narrowing than the usual lying-down scan. Researchers will compare both types of scans in 20 adults who are already scheduled for a standard CT. The goal is to see if the s…

This study aims to improve health literacy among women who are about to leave jail. About 279 participants will receive education on cervical and breast cancer, contraception, and sexually transmitted diseases. The goal is to empower them with knowledge to make healthier choices …

This study was designed to see if removing a urinary catheter early after minimally invasive lower back surgery helps patients walk sooner. It planned to compare early removal to delayed removal in adults having one- or two-level lumbar fusion. The study was withdrawn before enro…

This study aimed to see if singing-based exercises could be as effective as traditional speech therapy for older adults with swallowing problems. Researchers planned to measure muscle and brain activity during both types of exercises. However, the study was withdrawn before enrol…

This study looks at how blood pressure affects chronic pain in people who already have a spinal cord stimulator. About 36 adults with chronic low back pain and high blood pressure will take a standard blood pressure drug for 2 weeks and a placebo for 2 weeks (in random order) to …

This study looks at how different types of exercise (like walking or strength training) affect thinking skills and brain size in healthy older adults aged 65 to 80. About 280 participants will be followed for 12 months to see if exercise improves memory, attention, and other ment…

This study looks at whether giving nutrition through a feeding tube for only 12 hours a day is safe and works well for critically ill adults in the ICU. Researchers will compare this approach to the standard 24-hour feeding method. The goal is to see if the shorter schedule affec…

This study tests a web-based system called CATSystem that helps doctors follow guidelines for cervical cancer screening and treatment. About 6,600 women at 10 Kenyan hospitals will take part. The goal is to see if the tool increases the number of women who get proper screening an…

This study looks at whether drinking a special carbohydrate drink just before major urologic surgery can improve recovery and blood sugar control. About 30 adults without diabetes will be randomly assigned to get either a specialized sports drink or a standard one. Researchers wi…

This study planned to bring together teens aged 13-18 with insomnia to help design and test a new version of a mobile app called Firefly. The app was meant to teach healthy sleep habits using a type of therapy that works well for insomnia. However, the study was withdrawn before …

This study looks at how to help rural primary care doctors give better follow-up care to cancer survivors. It involves 16 clinics in Kansas and focuses on making sure survivors get recommended check-ups and screenings. The goal is to find practical strategies that improve care wi…