University Of Kansas Medical Center

This study tests if a common, low-cost drug called tranexamic acid can prevent blood clots under skin grafts in burn patients as well as the standard, more expensive drug thrombin. About 62 adults with small to moderate burns will receive one of the two drugs during their skin gr…

This study tests whether adding pirfenidone to the immunotherapy drug atezolizumab can help shrink tumors and overcome treatment resistance in people with stage 4 or recurrent non-small cell lung cancer. About 25 adults who have already had at least one prior treatment will recei…

This study tests two different drug combinations given before surgery to people with HER2-positive early breast cancer. The goal is to see which combo clears more cancer from the breast and lymph nodes. About 100 adults with stage II or III disease will take part. Results will he…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (ages 18-35) with mild-to-moderate intellectual disabilities lose more weight and maintain that loss over 24 months. Participants will be split into two groups: one gets …

This study looks at what happens to muscle and fat when people take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise makes a difference. About 40 adults will be assigned to standard care, aerobic training, or resistance t…

This study tests a new guideline to help children ages 6-11 in rural areas who have overweight or obesity. Over 1,000 families will either receive a healthy lifestyle program or a newsletter, while clinics get training or continue usual care. The goal is to see if these steps imp…

This early-phase trial tests a new treatment called DuoCAR-T for adults with B-cell lymphoma or leukemia that has returned or not responded to standard therapy. The treatment involves taking a patient's own immune cells, modifying them in a lab to better recognize and attack canc…

This study tests whether taking the medication bupropion for 6 months helps African American daily smokers quit better than the usual 7-week course. About 500 participants will be followed to see who stays smoke-free. The goal is to find a more effective way to support long-term …

This study tests whether 4th generation e-cigarettes can reduce harm and help people who both smoke and vape (dual users) quit regular cigarettes. About 500 adults who smoke at least 5 cigarettes daily will be given either e-cigarettes alone or e-cigarettes plus a stop-smoking me…

This early-stage trial tests a combination of two drugs, tagraxofusp and pacritinib, in about 20 adults with myelofibrosis (a type of bone marrow cancer) who have already tried standard JAK inhibitors or cannot take them. The main goals are to see if the combo can shrink an enlar…

This study tests whether metformin, a standard diabetes medication, can improve airway cell function in adults with cystic fibrosis-related diabetes (CFRD). Participants must already be taking a CFTR modulator drug. The trial involves 30 people and measures changes in ion channel…

This study is for women aged 65 and older with a common type of early-stage breast cancer (ER-positive, HER2-negative, up to 5 cm) who are not having surgery. They will receive 5 sessions of a precise radiation treatment called SABR. The goal is to see if this approach controls t…

This study tests a new radiation technique called vGRID SBRT for people with liver cancer that cannot be surgically removed. The goal is to find the highest safe dose of radiation that can shrink tumors while keeping side effects low. About 18 adults with advanced liver cancer wi…

This study is for people with certain blood cancers (like leukemia) who are getting a half-matched bone marrow transplant. Researchers are adding a dose of specially grown immune cells (gamma delta T-cells) after the transplant to see if it can kill any leftover cancer cells whil…

This study looks at how doctors can help endometrial cancer survivors who are overweight start a weight management program and possibly take weight loss medication. About 50 people who have finished early-stage endometrial cancer treatment will be referred to a weight loss clinic…

This study tests whether a dietary supplement called galacto-oligosaccharide (GOS) can prevent acute graft-versus-host disease (GVHD) in people receiving a stem cell transplant. The supplement aims to improve gut bacteria health, which may reduce the risk of GVHD. The trial invol…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, in addition to standard medication, can lower the chance of developing pancreatitis—the most common serious complication after ERCP. About 950 adults with a natural bile duct o…

This study compares two ways to deliver a diabetes prevention program to 160 adults in rural communities who have prediabetes. One group will join video sessions, the other will follow a self-directed plan. The goal is to see which approach works better for weight loss and blood …

This study tests a program that combines text message support with financial rewards to help low-income pregnant women stop smoking. About 30 women will either get texts plus incentives or texts alone. The goal is to see if the program is easy to use and acceptable, and to check …

This study aims to measure how much pain relief women get from a procedure called gonadal vein embolization for pelvic congestion syndrome, a condition that causes chronic pelvic pain. Researchers will enroll 30 women aged 18 and older who meet the criteria for the condition. The…

This study looks at whether adding yoga to a standard weight loss program helps adults with overweight or obesity lose more weight than just doing aerobic exercise alone. About 290 participants will follow a 12-month program with diet changes and either aerobic exercise plus yoga…

This study tests whether one-on-one sleep therapy via video calls works better than a self-guided website for improving sleep and reducing fatigue in people with multiple sclerosis (MS). About 90 adults with MS and insomnia will receive either live therapy, web-based lessons, or …

This study tests a text message program called CuidaTEXT for Latino caregivers of relatives with Alzheimer's disease. About 288 caregivers will receive texts with tips on care, self-care, and support, or no texts. Researchers will check if the texts help reduce depressive symptom…

This study looks at whether people who have surgery for a detached retina need to keep their head face-down for just one day instead of the usual seven. It involves 20 adults with a specific type of detachment. The goal is to see if a shorter time in that position still leads to …

This study tests whether a supplement called HMB can help female athletes regain muscle size and strength after ACL knee surgery. About 30 women will take either HMB or a placebo daily during their rehab. Researchers will measure muscle changes and strength over several months to…

This study compares a new type of needle used in a standard pain-relief procedure (radiofrequency ablation) against usual medical care for people with long-term low back pain. About 50 adults with pain lasting at least 6 months will take part. The goal is to see if the new needle…

This study compares two FDA-approved lasers (Holmium:YAG with MOSES and thulium fiber) for breaking large kidney stones during a minimally invasive surgery called mini-PCNL. About 150 adults with stones larger than 15mm will be randomly assigned to one laser, both using a suction…

This study is testing whether a remote exercise and dementia care program works well for older adults with Down syndrome (over 35) and their caregivers. The program is delivered from home and aims to see if it's practical and helpful. About 40 participants will take part to check…

This study looks at 260 young adults from a larger lung health study. They will get a special MRI scan that uses a harmless gas to take detailed pictures of their lungs. The goal is to find early signs of lung problems before they turn into serious disease. No treatment is given—…

This study collects blood and urine samples from 250 people with early-stage polycystic kidney disease (PKD), their unaffected siblings, and healthy volunteers. The goal is to create a biobank that helps researchers find biological markers of disease progression. Participants do …

This study tests a program called Talk With Me Baby, which teaches parents how to have more language-rich interactions with their infants during regular well-child doctor visits. Researchers will enroll 400 parent-child pairs and compare those who receive the program to those who…

This study tests a 6-session family program called NOURISH-ALL for children ages 2-12 with acute lymphoblastic leukemia (ALL) and their caregivers. The goal is to see if families will join and stick with the program, which focuses on healthy eating, physical activity, and reducin…

This study looks at how mucus plugs block airways in people with severe asthma. Using special MRI scans, researchers will measure how these plugs affect air flow and gas exchange in the lungs. The goal is to better understand the problem, not to test a new treatment. About 5 adul…

This study looks at how estrogen levels influence changes in body composition, muscle function, and bone health in women aged 35-60 who are starting a GLP-1RA medication for weight loss. Researchers will measure weight, lean and fat mass, bone density, and muscle strength over ti…

This study tests whether guided mental imagery can help mid-life adults stay motivated to exercise regularly. Researchers will track how often 160 participants attend workouts and measure changes in brain activity using MRI. The goal is to find a simple way to improve long-term e…

This study is a registry for people with triple negative breast cancer or those with inherited genetic mutations linked to breast cancer. It aims to collect information on genetic mutations, treatment responses, and long-term survival. Up to 1500 participants will be followed ove…

This study tests whether a home-based mobile app can help 3-4 year olds who currently meet few movement guidelines improve their physical activity, sleep, and screen time. About 80 children and their parents will use the app for 12 weeks, with researchers tracking changes using a…

This study looks at whether giving surgeons live information about pressure inside the kidney helps them make better decisions during stone-removal surgery. About 80 adults with large kidney stones will take part. The main goal is to see if the pressure data changes how the surge…

This study looks at whether providing bags of food to patients who have trouble affording groceries can improve nutrition and outcomes for those receiving stem cell transplants or CAR-T cell therapy. About 210 children and adults aged 8 to 80 who screen positive for food insecuri…

This study follows 450 people with FSHD for at least 3 years to track how the disease affects walking, arm use, breathing, and other daily activities. By collecting detailed measurements, researchers hope to improve patient care and help design better clinical trials for future t…

This study looks at whether eating more eggs during pregnancy can improve a baby's brain development. Pregnant women between 12-20 weeks will be split into two groups: one that eats 10-14 eggs per week and another that follows a healthy diet. Researchers will measure the baby's h…

This study is for children aged 5 to 17 with a confirmed diagnosis of FSHD, a type of muscular dystrophy. Researchers want to see if certain tests, like the FSHD-COM and reachable workspace, are good ways to measure muscle function in kids. The goal is to improve how future clini…

This study is creating a registry—a bank of information and samples—from up to 1,000 people with bladder cancer. Researchers will use the collected blood, urine, and tissue to learn how tumors develop, come back, and affect long-term survival. Participants can join other studies …

This study looks at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will use special CT scans taken while standing to see the knee in a natural position. The goal is to find links between specific knee features and symptoms, which could help doct…

This study aims to create a better way to measure balance in adults with spinal deformities like scoliosis. Researchers will use wearable sensors and a force plate to track how far people can reach while standing, comparing patients to healthy adults. The goal is to give surgeons…

This study is looking at tiny particles called exosomes in the blood of people with rectal cancer. The goal is to see if these particles can help predict how well a patient responds to chemotherapy and radiation before surgery. Researchers will compare exosome levels before, duri…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this data to improve imaging techniques and understand what the images mean for patient health. Participants must already be enrolled…

This study aims to see if a special planning tool helps more people get screened for colorectal cancer. About 2,200 patients from 20 primary care clinics will use the tool to decide when and how to get screened. The goal is to find the best way to make screening a routine part of…

This study is for adults with solid tumors who are eligible for pembrolizumab or nivolumab. It compares higher doses (every 4-6 weeks) to lower doses (every 2-3 weeks) to see which causes fewer severe immune-related side effects. The goal is to find the safest dosing schedule wit…

This study explores whether placing community health workers in rural schools can help students with poor attendance by addressing underlying social needs like housing, food, or healthcare. Researchers will work with about 38 students and their families to see if this approach is…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis and pulmonary fibrosis. Researchers will collect medical data and biological samples from up to 1,000 participants to support future studies. The goal is to bette…

This study looks at how bladder cancer treatment changes your body's energy use and muscle function. Researchers will measure resting energy in 30 patients before and after chemotherapy and bladder removal surgery. The goal is to learn more so doctors can design better care plans…

This study looks at how well a tool called RetroPerc helps doctors reach and remove kidney stones during a standard surgery. About 150 adults who are already scheduled for this surgery will take part. The goal is to see how often the device works on the first try and where it wor…

This study looks at how daily stress and related feelings impact weight loss, physical activity, and sleep in 50 adults with obesity who are already in a weight loss program. Participants will wear a device to track activity and sleep, and answer short surveys on their phones abo…

This study looks at 120 people having surgery to remove a blood clot after a stroke. It compares two types of anesthesia: one given through a vein (propofol) and one inhaled (sevoflurane). The goal is to see which method leads to better recovery and independence 90 days later.

This study will follow about 200 gender minority adults, some starting gender-affirming hormone therapy and some not, to see how chronic pain changes over a year. Participants will fill out surveys, and some will also have pain sensitivity tests, brain MRIs, and interviews. The g…