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Which laser blasts kidney stones faster? new trial aims to find out

NCT ID NCT07087977

Symptom relief Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two types of lasers (holmium:YAG and thulium fiber) used during a minimally invasive surgery to break up large kidney stones. About 150 adults with stones larger than 15 mm will be randomly assigned to one laser or the other. The goal is to see which laser works faster and clears stones more completely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
laser (holmium:YAG or thulium fiber)
What this could lead to
If one laser proves faster or more effective, it could become the preferred option for kidney stone surgery, reducing operation time and improving stone removal.
What could go wrong
This is a small, early-stage comparison of already-approved devices, so major breakthroughs are unlikely. Results may not apply to all patients or stone types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males or females over 18 years of age 2. Patients with kidney stones, with stone burden larger than 15 mm. 3. Patients undergoing new percutaneous access with primary, supine, unilateral mini-PCNL. Exclusion Criteria: 4. Simultaneous use of more than 1 laser platform or other form of fragmentation (e.g., ultrasonic). 5. Patients undergoing simultaneous treatment of contralateral kidney stones during the same procedure. 6. Patients undergoing simultaneous treatment of ureteral stones during the same procedure. 7. Pregnant patients. 8. Presence of genitourinary anatomical abnormalities. 9. Uncorrected coagulopathy. 10. External urinary catheters. 11. Immunosuppressed patients. 12. Non-elective procedures.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney stone Nephrolithiasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

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