University Of Calgary

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney damage. About 1,040 children will be randomly assigned to either high-volume fluids or standard care. The goal is to see if this simple approach reduces the need…

This study tests a wellness program for people waiting for or recovering from a kidney or liver transplant. The program includes exercise, nutrition advice, stress reduction, and sleep support to improve quality of life and physical fitness. Researchers will see if the program he…

This study tests whether a virtual home hospital program with remote monitoring can help adults recovering from acute kidney injury spend more days at home and avoid repeat hospital visits. About 354 participants will receive either usual care or a digital health package that inc…

This study tests a stem cell transplant for children with sickle cell disease who have a family donor with a different blood type. The goal is to see if a milder conditioning regimen can safely allow the transplant to work. Up to 12 children will take part. If successful, this co…

This study tests whether taking a prebiotic fiber supplement for 6 months can help people with type 1 diabetes better control their blood sugar and reduce dangerous lows. The researchers will also look at how the supplement affects gut bacteria and gut health. The study involves …

This study aims to find the safest and most effective dose of the clot-busting drug tenecteplase for people having a severe stroke. About 4,000 participants will receive either a standard or lower dose, or no drug at all in certain cases, to see which approach leads to the best r…

This study is testing a small, hand-held biosensor to see if it can accurately measure a brain injury marker in the blood of adults with mild concussions. Researchers will compare the device's results to standard lab tests and track symptoms over 12 weeks. If successful, this cou…

This study looks at whether giving IV fluids right before and during an ERCP procedure can prevent pancreatitis, a common complication. Researchers will observe 13,000 adults to find the best amount and timing of fluids. The goal is to create a simple, practical plan that works f…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's disease and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with mild memory concerns but no dementia. Participants will be as…

This study tests if giving short-term IV fluids around the time of an ERCP procedure can prevent pancreatitis, a common and serious side effect. About 505 adults aged 18-75 who are having their first ERCP will be randomly assigned to different fluid plans. The goal is to find a s…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help people aged 18-65 with concussion symptoms lasting over 3 months. Forty participants will receive either a high or low dose of psilocybin, plus we…

This study tests if injecting botulinum (like Botox) into leg muscles can reduce pain during exercise for people with chronic exertional compartment syndrome. About 50 adults will get either the real injection or a placebo (salt water). Researchers will track pain levels and leg …

This study looks at whether a large IV bag of salt water (saline) can improve thinking and memory in people with Long COVID or POTS who experience brain fog. Researchers will compare the effects of a full 999 mL dose versus a tiny 50 mL placebo in 100 adults. The goal is to find …

This study tests if a non-invasive brain stimulation technique called theta burst rTMS can reduce ADHD symptoms like poor attention and hyperactivity in children aged 9 to 15. Researchers will measure attention and quality of life changes. The goal is to find an alternative to st…

This study looks at whether wearing compression garments (like tight leggings or abdominal shapewear) during everyday activities can help lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS). Researchers will test commercially avail…

This study tests if a custom mouth device that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate, and oxygen levels. Researchers will compare it to a placebo device in 24 healthy adults aged 40-65. Participants wear each device for several week…

This study is testing whether a pain-relief gel applied to the skin works as well as pain pills for children aged 6 to 18 with ankle or knee injuries. The goal is to see if a larger study is possible. Participants will use either the gel or the pills three times a day for three d…

This study tests a simple device that lets people breathe in a little extra carbon dioxide (CO2) to raise blood pressure. It is for people with neurogenic orthostatic hypotension, a condition where blood pressure drops sharply when standing, causing dizziness or fainting. About 2…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will measure symptom changes using questionnaires. The goal is to see if this …

This study is testing an 8 to 12 week exercise program for people who have or had cancer. The program includes supervised exercise classes, either online or in person, twice a week. The goal is to help participants increase their physical activity and reduce cancer-related sympto…

This study tests whether probenecid, a safe drug already used for gout, can reduce the unpleasant symptoms of opioid withdrawal. About 40 adults with chronic pain who are voluntarily lowering their opioid dose will receive probenecid or a placebo. The goal is to see if probenecid…

This study looks at whether breathing air with a little extra carbon dioxide can raise blood pressure and improve blood flow to the brain in people with neurogenic orthostatic hypotension (NOH). NOH causes a big drop in blood pressure when standing, leading to light-headedness, n…

This study tests a program that lets cancer patients report symptoms from home using a digital questionnaire. A nurse then gives tailored advice. The goal is to see if this improves quality of life and reduces emergency visits. About 1055 adults with cancer will take part.

This study tests a safe, non-invasive device that sends mild electrical pulses through the ear to stimulate the vagus nerve, which helps control pain and stress. Researchers want to see if this treatment is practical and helpful for 40 people with chronic whiplash (lasting 3 mont…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heartbeat and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. Participants will have tests like tilt-table e…

This study tests whether a robotic gait trainer (the Trexo) can help children and adults with walking impairments from conditions like cerebral palsy or brain injury. Researchers will see if a structured hospital-based training program is practical and helps participants achieve …

This study tests whether cannabis (CBD) can reduce the number of headache days in people with chronic migraines. About 72 adults will receive either a low or high dose of CBD or a placebo. Researchers will compare headache frequency before and after treatment to see if CBD helps …

This study looks at whether a child's genes can predict if they will have a rare but serious side effect from common antidepressants (SSRIs) called behavioral disinhibition, which can cause agitation or impulsivity. Researchers will collect saliva samples from 120 children and yo…

This study tests whether having patients fill out online surveys about their quality of life and heart symptoms before a doctor visit helps improve communication and care. About 200 adults with known or suspected coronary artery disease and their cardiologists will take part. The…

This study is testing how much walking practice on a special treadmill (split-belt treadmill with virtual reality) people who recently had a stroke can handle in one day. The goal is to find the right amount of training that is safe and tolerable. 72 stroke survivors who had thei…

This study looks at how changing heart rate changes blood flow to the brain. Researchers will temporarily pace the hearts of 20 adults already scheduled for a heart procedure, then measure brain blood flow using ultrasound. The goal is to better understand the relationship, not t…

This study is creating a detailed database of 6,000 adults who undergo a procedure called ERCP, used to diagnose and treat problems in the bile ducts or pancreas. Researchers are collecting information before, during, and after the procedure to track complications like pancreatit…

This study looks at better ways to diagnose bile duct stones, a common but serious condition. Researchers will check if changes in liver enzyme levels can help decide who truly needs a procedure called ERCP, which carries risks. The goal is to spare patients from unnecessary proc…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will use mild oxygen changes and a placebo to measure responses. The goal is to better understand conditions like sleep apnea, not to treat them directly.

This study looks at how different types and doses of oral iron supplements affect iron levels, exercise performance, and gut health in young female athletes with low iron stores. Participants will take one of three iron supplements every other day for 12 weeks and complete fitnes…

This study looks at how a robotic walking trainer called Trexo helps people with physical disabilities, like cerebral palsy, improve their walking. Researchers want to understand why it works and how to make it better. About 50 participants will try different settings on the robo…

This study aims to find out if the intense, subjective experience caused by psilocybin (the active ingredient in magic mushrooms) is necessary for its positive after-effects. Researchers will give 128 healthy adults either psilocybin alone or psilocybin with risperidone, a drug t…

This study looks at how well different first aid methods (like back blows and abdominal thrusts) work for adults and children over age 2 who are choking. Researchers in Alberta, Canada will collect information from real choking incidents to see which treatments are safest and mos…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. Researchers will enroll 52 adults who use a walking aid most of the time due to a leg injury, stroke, or multiple sclerosis. The goal is t…

This study aims to see if a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out health questionnaires and let the app monitor their steps and activity for a year. The goal is to better understand how patients heal and improve f…

This study is for girls and women aged 10 and older with or without ADHD who live in Canada. Researchers want to learn how ADHD affects their mental health, hormones, and overall well-being over time. Participants fill out online surveys about their health and life experiences. T…

This study aims to find out if people with POTS have certain antibodies that may play a role in the condition. Researchers will compare blood samples from 125 participants (ages 18-60) with and without POTS. No treatments or interventions are given—only observation and blood test…

This study explores how a child's genes influence their response to a common ADHD medication called methylphenidate. Researchers will track symptom changes and side effects in 400 participants aged 6 to 24 across Western Canada. The goal is to find genetic markers that could help…

This study tests whether using a person's genetic information can help doctors pick the best antidepressant for teenagers aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either receive a drug choice based on their genes or follow standard presc…

This study tests whether brain-computer interfaces (BCI) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. The goal is to see if BCI helps them achieve personal life participation goals and if the program can reac…

This study tests an online decision aid called "My Heart Care and CKD" for people with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for kid…

This study looks at whether giving donor breast milk instead of formula to full-term babies born by C-section can help restore their gut bacteria. About 90 mothers and their infants will take part, with some babies getting donor milk and others getting formula when extra feeding …

This study follows 90 adults with Crohn's disease who are starting a new treatment called guselkumab. Researchers use intestinal ultrasound and blood protein tests to see how well the drug works over one year. The goal is to find better ways to measure treatment response without …

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and test memory and physical function in 150 participants. The goal is to find factor…

This study follows 825 pregnant women who need blood thinners for blood clots to see how doctors manage their medication around childbirth. The goal is to learn which strategies lead to fewer bleeding problems. No new treatments are tested; instead, researchers observe real-world…

This study looks at how different heart rates and body positions change the amount of blood the heart pumps. Researchers will safely adjust the heart rates of 25 people with pacemakers to measure blood flow. The goal is to better understand fainting spells (vasovagal syncope) and…

This study looks at how well different first aid techniques work for infants (up to 2 years old) who are choking. Researchers in Alberta, Canada will collect information from real-life choking incidents to see which treatments are safest and most effective. The goal is to improve…

This study tests a new, non-invasive method to measure how well the heart and blood vessels work in adults with and without heart failure. Participants will have a single 20-minute visit where they squeeze a handgrip device while wearing sensors. The goal is to see if this simple…

This study looks at whether increasing carbon dioxide (CO2) levels can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 concentrations to find the most effective one. The s…

This study looks at whether a less invasive fine needle biopsy can give the same genetic information as a larger surgical sample in people with papillary thyroid cancer. About 130 adults with suspected or confirmed thyroid cancer will have both samples tested using the Thyroid Gu…