The First Affiliated Hospital With Nanjing Medical University

This study tests a combination of three drugs (orelabrutinib, rituximab, and possibly lenalidomide) in people with untreated marginal zone lymphoma that has spread. The goal is to see how well the treatment shrinks or eliminates the cancer. About 50 adults will take part, and the…

This early-phase study tests a new cell therapy called LVIVO-TaVec200 in 36 adults with multiple myeloma that has returned or not responded to treatment. The goal is to check safety, find the right dose, and see how long the therapy stays in the body. Participants receive the tre…

This early-phase study tests whether stem cells from amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. The goa…

This study tests whether a 7-day combination of vonoprazan, high-dose amoxicillin, and bismuth can effectively eradicate H. pylori bacteria in the stomach. About 316 adults with H. pylori infection will be randomly assigned to either the 7-day experimental regimen or a standard 1…

This study tests a combination of three treatments—bemosubaiabimab (an immunotherapy), anlotinib (a targeted therapy), and standard chemoradiation—in people with esophageal cancer that has spread to a few other spots (oligometastatic). The goal is to see if this mix can shrink tu…

This study tests whether giving two drugs (thiotepa and trastuzumab) directly into the fluid around the brain and spinal cord can shrink tumors in the brain lining caused by HER2-positive breast cancer. About 26 people with this specific type of cancer spread will receive the tre…

This study is for people with a type of breast cancer called HER2-negative that has spread to the brain. It tests whether adding a drug called anlotinib to standard radiation therapy can help control the cancer in the brain for longer. About 39 participants will receive this comb…

This study compares a new pacing method called LOT-CRT to standard biventricular pacing in 86 heart failure patients with a specific type of heart block (NICD). The goal is to see if LOT-CRT better preserves or improves the heart's pumping ability. Participants will be followed f…

This study tests a combination of two drugs, tislelizumab and anlotinib, as a second treatment option for people with thymoma or thymic carcinoma whose cancer worsened after initial chemotherapy. The trial will enroll 20 participants and measure how many patients see their tumors…

This study tests whether using focused ultrasound (HIFU) to destroy tumors, with or without an immune-boosting drug (PD-1 inhibitor), before standard chemotherapy can improve outcomes for people with early-stage triple-negative breast cancer. About 58 participants will receive on…

This study looks at whether a class of diabetes drugs called GLP-1 receptor agonists (like semaglutide) can improve nerve damage in the heart caused by type 2 diabetes. About 60 adults with type 2 diabetes will receive either standard care or standard care plus a weekly injection…

This study tests whether adding venetoclax to standard BTK inhibitor therapy can help people with chronic lymphocytic leukemia (CLL) stop all treatment after a set period. About 79 adults who have been on a BTK inhibitor for at least 6 months will receive both drugs for 12 cycles…

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults will receive the cells in increasing doses to f…

This study tests whether adding an immune-boosting drug (thymosin alpha 1) to standard chemo-immunotherapy and radiation can improve outcomes for people with stage III gastroesophageal junction cancer. About 48 participants will receive either the standard treatment or the standa…

This study looks at two different ways to pace the heart in people with heart failure who already have a pacemaker and need an upgrade. The goal is to see if a newer method, called conduction system pacing, works as well as the standard method, biventricular pacing. About 66 adul…

This early study tests a new medicine called SC101, given as a single injection around the kidneys, for people with resistant high blood pressure and moderate to severe chronic kidney disease. The main goal is to check if the treatment is safe and to see how it affects blood pres…

This study tests whether a new combination of drugs (orelabrutinib, zebetuzumab, and lenalidomide) works better than a standard combination (bendamustine and rituximab) for people newly diagnosed with marginal zone lymphoma, a slow-growing blood cancer. About 169 adults aged 18-7…

This study tests a new combination of drugs (linperlisib plus chemotherapy and thalidomide) in 180 adults with relapsed or refractory non-Hodgkin lymphoma. The goal is to see if the combo can shrink tumors and control the disease. Participants must have certain lymphoma types and…

This study looks at whether the drug durvalumab can safely help control limited-stage small cell lung cancer after initial chemoradiotherapy. Researchers will review medical records of 25 patients who received durvalumab as a follow-up treatment. The main goal is to check for ser…

This study tests whether adding a targeted drug (HRS-4642) to standard chemotherapy can shrink locally advanced pancreatic tumors enough to allow surgery. About 30 adults with a specific gene mutation (KRAS G12D) will receive the combination. The goal is to see how many tumors re…

This early-phase study tests a new type of CAR-T therapy that targets two proteins (CD19 and CD20) on cancer cells. It is designed for adults with B-cell blood cancers that have relapsed or not responded to standard treatments. The main goals are to check safety, find the right d…

This study tests a combination of four drugs (zanubrutinib, rituximab, lenalidomide, and tislelizumab) in 33 adults with follicular lymphoma that has returned or not responded after at least two prior treatments. Participants receive 6 cycles of the combination, then those who re…

This study looks at whether adding an immunotherapy drug (sintilimab) to standard chemotherapy (SOX) can help prevent stomach cancer from coming back after surgery. It involves 460 adults with a specific type of advanced stomach cancer (stage N3, PD-L1 positive). Participants wil…

This study tests a combination of four drugs (PD-1 inhibitor, rituximab, methotrexate, and orelabrutinib) in 50 people with newly diagnosed or relapsed lymphoma that has spread to the brain. The main goal is to see how many patients remain cancer-free one year after treatment. Th…

This study is testing a newer, less invasive surgical technique for breast cancer. It uses a tiny camera (endoscope) to help the surgeon remove the breast (mastectomy) and rebuild it right away. The goal is to see if this approach is as safe and effective as standard surgery, whi…

This study tests a new treatment plan for people with locally advanced rectal cancer. Participants first get a short course of radiation plus a drug called IL-2, then receive chemotherapy and two immunotherapy drugs. The goal is to see if this combination can make the cancer comp…

This study tests a combination of two drugs (disitamab vedotin and bevacizumab) in people with HER2-low breast cancer that has spread and stopped responding to a prior treatment called T-DXd. About 37 adults will receive the combo to see if it shrinks tumors and how safe it is. T…

This study compares a new drug, romiplostim N01, to an existing one (IL-11) for cancer patients whose platelet counts drop due to chemotherapy, radiation, or other treatments. About 88 adults with various cancers and low platelets will be randomly assigned to one of the two drugs…

This early-phase study tests whether a patient's own natural killer (NK) cells can safely treat lung nodules. About 24 adults aged 18-70 with high-risk nodules will receive increasing doses of the cell therapy. The main goal is to check for side effects within 28 days, with a sec…

This study looks at how safe robotic surgery is for removing gastrointestinal stromal tumors (GISTs) that are in tricky spots in the stomach. About 182 people with small to medium-sized tumors (2 to 5 cm) will have the surgery and be watched for 3 years to see if the tumors come …

This study tests whether adding the targeted drug disitamab vedotin to standard chemotherapy (SOX) after surgery can help prevent stomach cancer from returning. It is for people with stage III HER2-positive stomach cancer who have had their tumor fully removed. The trial will com…

This study tests whether giving a mix of immunotherapy (PD-1 blocker and IL-2) plus chemotherapy before surgery can shrink tumors more effectively in people with locally advanced rectal cancer. About 130 adults with a specific type of rectal cancer (MSS/pMMR) will take part. The …

This study tests a combination of three drugs (glofitamab, a PD-1 inhibitor, and lenalidomide) in 24 people with a type of large B-cell lymphoma that has returned or not responded to treatment and has a specific gene change (TP53). The goal is to see if this combination can shrin…

This study aims to see if a new type of MRI using a contrast agent called ferumoxytol can better detect calcium buildup in heart arteries compared to standard CT scans. About 100 adults with known calcium blockages will receive both scans, and results will be checked against the …

This study tests an artificial intelligence (AI) system that analyzes routine contrast-enhanced CT scans to detect gastric cancer and determine its stage (how far it has spread). The goal is to help doctors plan the best treatment, such as surgery or chemotherapy. The study will …

This study tests a personalized sound therapy for people with chronic tinnitus (ringing in the ears lasting over 6 months). Researchers will give 200 participants custom sound clips based on their hearing loss and tinnitus pitch, aiming to retrain the brain to reduce the perceive…

This study tests whether using ultrasound can help two common melasma medicines (tranexamic acid and glutathione) get deeper into the skin. Melasma causes dark patches on the face, and these medicines are hard to absorb because they are water-based. The trial will compare treated…

This study aims to improve how doctors assess disease activity in people with axial spondyloarthritis (axSpA), a type of arthritis that mainly affects the spine. Researchers will use whole-body MRI scans and machine learning to create a new assessment model. The study will follow…

This study is looking for 1,000 pregnant women to help researchers understand what causes gestational diabetes and how to predict it. The goal is to create a tool that can identify women at risk early. Then, a special health program will be tested to see if it can improve blood s…