The First Affiliated Hospital With Nanjing Medical University

This study tests a special balloon that uses shockwaves to break up hard calcium deposits in heart arteries. It will include 200 people with severe blockages. Researchers will check if the treatment is safe and helps keep arteries open.

This study tests whether giving a PD-L1 antibody plus chemoradiotherapy before a liver transplant can help patients with advanced bile duct cancer that cannot be removed by surgery. About 25 adults aged 18-70 will receive this combination therapy. The main goal is to see how many…

This study tests whether adding an experimental immunotherapy drug (QL1706) to standard chemotherapy (SOX) before surgery can completely eliminate stomach cancer in adults with advanced but removable tumors. About 74 people aged 18-75 will be randomly assigned to get either the c…

This study tests a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy as a first treatment for people with advanced HER2-negative stomach or gastroesophageal junction cancer. The goal is to see if this approach can delay cancer growth and …

This early-stage study tests whether transplanting lab-grown retinal cells (made from stem cells) into the eye is safe for people with late-stage age-related macular degeneration (AMD). Nine adults aged 50 to 80 will receive the cell injection under the retina. The main goal is t…

This study tests whether adding the drugs SHR-1701 and apatinib to standard chemotherapy before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 80 adults will be randomly assigned to receive either SHR-1701 plus che…

This early-phase study tests an injection called LV009 in 19 adults with CD19-positive blood cancers that have come back or not responded to treatment. The main goal is to check safety, but researchers will also watch for signs that the cancer shrinks or disappears. Participants …

This study compares two types of minimally invasive surgery for stomach cancer that has spread to the outer stomach wall (cT4a). About 335 adults aged 18-80 will be randomly assigned to have their tumor removed with either robot-assisted or laparoscopy-assisted surgery. The main …

This study tests whether a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) plus chemotherapy and a targeted therapy can shrink locally advanced stomach or gastroesophageal junction cancer in patients with specific genetic markers (MSI-H/dMMR). The goal is to…

This study tests whether adding 4 cycles of the drug T-DXh can eliminate leftover cancer in women with HER2-positive breast cancer who still have disease after standard chemotherapy. About 59 participants will receive T-DXh before surgery. The goal is to see if more patients can …

This study tests two different chemotherapy combinations in 70 adults whose diffuse large B-cell lymphoma has returned more than a year after initial treatment. Participants will receive either the modified R-MINE regimen or the R-GemOx regimen for four 3-week cycles. The goal is…

This study tests a combination of two drugs (anlotinib and bempegaldesleukin) plus standard chemoradiotherapy in 46 people with advanced soft tissue sarcoma that cannot be removed by surgery. The goal is to see if the treatment shrinks tumors and how safe it is. Participants will…

This study tests whether adding the drug nimotuzumab to standard chemotherapy (nab-paclitaxel and gemcitabine) helps people with high-risk pancreatic cancer that can be surgically removed. About 156 adults will receive either the drug combination or a placebo before and after sur…

This early-phase study tests a new treatment called RN1701 for people with B-cell lymphoma that has returned or not improved after standard therapy. RN1701 uses specially engineered immune cells (CAR-T cells) from a donor to find and attack cancer cells. The main goal is to check…

This study tests whether adding brentuximab vedotin to standard chemotherapy (R-CHP) works better for people newly diagnosed with a rare, aggressive lymphoma linked to the Epstein-Barr virus. About 25 adults will receive the combination and be followed for 2 years to see if the c…

This study tests the drug SHR2554 as a maintenance therapy for people with peripheral T-cell lymphoma (PTCL) who have responded to their first treatment. The goal is to see if taking this drug can help keep the cancer from coming back longer. About 30 adults whose cancer is in re…

This study tests whether adding megestrol acetate oral suspension to standard chemoimmunotherapy can prevent weight loss and improve appetite in 48 people with stage III stomach cancer who are experiencing cachexia (severe wasting). Participants will either receive the drug plus …

This study tests whether combining two sedative drugs (esketamine and dexmedetomidine) can safely reduce the time ICU patients spend in a confused, agitated state called hyperactive delirium. About 132 adults on non-invasive breathing support will receive either the drug combo or…

This study compares two surgical methods—conventional and endoscopic—for nipple-sparing mastectomy with breast reconstruction in 170 women with early-stage breast cancer. The goal is to see which approach leads to better recovery of breast skin sensation after surgery. Researcher…

This study tests a new robotic surgery to remove breast gland tissue in 20 men with gynecomastia (enlarged breasts) that hasn't improved with medication. The surgery uses a single-port robot to try to improve patient satisfaction and recovery. The goal is to see if this approach …

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis (a condition where the spine narrows and presses on nerves). One surgery just removes the pressure on the nerves, while the other also fuses the bones together. The…

This study tests whether a sedative called remimazolam can lower the chance of confusion (delirium) after stomach cancer surgery in people aged 65 and older. Half of the 170 participants will get remimazolam, the other half standard sedatives. The goal is to see if remimazolam le…

This study looks back at data from 201 people with triple-negative breast cancer who received chemotherapy or immunotherapy before surgery. The goal is to see which treatment leads to a complete response (no cancer left) and what factors affect success. It does not test a new tre…

This study looks at 32 adults with liver cirrhosis to see if their blood proteins and gut bacteria differ between those who develop hepatic encephalopathy (brain fog) and those who don't. By identifying unique patterns, researchers hope to better understand the condition and guid…